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Chaperonin containing TCP1, subunit 7

Ccth, CCTeta, CCT7, Cctz, nip7-1, NIP-7
This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009] (from NCBI)
Top mentioned proteins: endothelin receptor, TRIC, CCT2, CCT5, HAD
Papers on Ccth
Dysfunctional nitric oxide signalling increases risk of myocardial infarction.
Impact
Schunkert et al., Lübeck, Germany. In Nature, 2014
Here we report the segregation of two private, heterozygous mutations in two functionally related genes, GUCY1A3 (p.Leu163Phefs*24) and CCT7 (p.Ser525Leu), in an extended myocardial infarction family.
Molecular characterization and phylogenetic analysis of Babesia sp. NV-1 detected from wild American Mink ( Neovison vison ) in Hokkaido, Japan.
Ishihara et al., Ebetsu, Japan. In J Parasitol, 2013
One of 13 animals was positive, as indicated by nested PCR targeting the 18S ribosomal RNA (SSU rDNA) and subunit 7 (eta) of the chaperonin-containing t-complex polypeptide 1 (CCT7) genes from species of Babesia and Theileria.
G-protein signaling modulator-3 regulates heterotrimeric G-protein dynamics through dual association with Gβ and Gαi protein subunits.
Siderovski et al., Chapel Hill, United States. In J Biol Chem, 2012
We provide evidence that GPSM3 increases Gβ stability until formation of the Gβγ dimer, including association of the Gβ-GPSM3 complex with phosducin-like protein PhLP and T-complex protein 1 subunit eta (CCT7), two known chaperones of neosynthesized Gβ subunits.
Nitrile hydratase genes are present in multiple eukaryotic supergroups.
Walker et al., Cambridge, United Kingdom. In Plos One, 2011
METHODOLOGY/PRINCIPAL FINDINGS: Here we report the detection of nitrile hydratase genes in five eukaryotic supergroups: opisthokonts, amoebozoa, archaeplastids, CCTH and SAR.
Integrating comparative expression profiling data and association of SNPs with Salmonella shedding for improved food safety and porcine disease resistance.
Tuggle et al., Ames, United States. In Anim Genet, 2011
The genes with associated SNPs included GNG3, NCF2, TAP1, VCL, AMT, CCR1, CD163, CCT7, EMP1 and ACP2.
Identification and phylogenetic analysis of Japanese Macaque Babesia-1 (JM-1) detected from a Japanese Macaque (Macaca fuscata fuscata).
Ishihara et al., Ebetsu, Japan. In Am J Trop Med Hyg, 2011
Molecular characterization of the parasite using nested-polymerization chain reactions targeting the 18S rRNA, β-tubulin, and subunit 7 (eta) of the chaperonin-containing t-complex polypeptide 1 (CCT7) genes were identified as a B. microti-like parasite, designated the Japanese Macaque Babesia-1 (JM-1).
Intron sequences from the CCT7 gene exhibit diverse evolutionary histories among the four lineages within the Babesia microti-group, a genetically related species complex that includes human pathogens.
Ishihara et al., Ebetsu, Japan. In Jpn J Infect Dis, 2010
Recent analyses of β-tubulin and the eta subunit of the chaperonin-containing t-complex protein 1 (CCT7) genes revealed discrete clusters (a species-complex comprised of at least 4 taxa for the U.S., Kobe, Munich, and Hobetsu).
Molecular evidence of the multiple genotype infection of a wild Hokkaido brown bear (Ursus arctos yesoensis) by Babesia sp. UR1.
Ishihara et al., Ebetsu, Japan. In Vet Parasitol, 2010
In order to enhance information obtained from the SSU rDNA sequence, further detection and sequence analysis of the CCTeta gene sequence were done revealing the simultaneous presence of three closely related genotypes (all in a monophyletic lineage) within a single bear host.
Equivalent mutations in the eight subunits of the chaperonin CCT produce dramatically different cellular and gene expression phenotypes.
Horovitz et al., Israel. In J Mol Biol, 2010
By contrast, cells with the mutation in subunit CCT7 are the only ones to accumulate juxtanuclear protein aggregates that may reflect an impaired stress response in this strain.
Slt2 and Rim101 contribute independently to the correct assembly of the chitin ring at the budding yeast neck in Saccharomyces cerevisiae.
Roncero et al., Salamanca, Spain. In Eukaryot Cell, 2009
Growth of the slt2Delta rim101Delta double mutant was restored by the overexpression of the GFA1 or CCT7 genes, which code for two biologically unrelated proteins.
The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1.
Pitson et al., Adelaide, Australia. In Int J Biochem Cell Biol, 2009
Further analysis of the SK1-CCTeta interaction demonstrated that other CCT/TRiC subunits also associated with SK1 in HEK293T cell lysates in an ATP-sensitive manner, suggesting that the intact, functional, multimeric CCT/TRiC complex associated with SK1.
Discovery and scoring of protein interaction subnetworks discriminative of late stage human colon cancer.
Chance et al., Cleveland, United States. In Mol Cell Proteomics, 2009
Others have been recently identified as potential markers of CRC (IFITM1), and the role of others is largely unknown in this disease (CCT3, CCT5, CCT7, and GNA12).
Correlating blood immune parameters and a CCT7 genetic variant with the shedding of Salmonella enterica serovar Typhimurium in swine.
Bearson et al., Ames, United States. In Vet Microbiol, 2009
We have further performed association studies on these immune response parameters as well as shedding status of the Salmonella-infected pigs with a single nucleotide polymorphism (SNP) in the porcine gene CCT7, previously shown by our group to be transcriptionally up-regulated in swine experimentally inoculated with Salmonella Typhimurium.
Babesia microti-group parasites compared phylogenetically by complete sequencing of the CCTeta gene in 36 isolates.
Ishihara et al., Ebetsu, Japan. In J Vet Med Sci, 2009
This study was conducted to clarify the intra- and inter-group phylogenetic features of the B. microti-group parasites with the eta subunit of the chaperonin-containing t-complex polypeptide l (CCTeta) gene as a candidate genetic marker for defining the B. microti group.
Microarray analysis of oxidative stress regulated genes in mesencephalic dopaminergic neuronal cells: relevance to oxidative damage in Parkinson's disease.
Kanthasamy et al., Ames, United States. In Neurochem Int, 2007
Changes in genes encoding pro- or anti-apoptotic proteins included up-regulation of BIK, PAWR, STAT5B, NPAS2, Jun B, MEK4, CCT7, PPP3CC, and PSDM3, while key down-regulated genes included BNIP3, NPTXR, RAGA, STK6, YWHAH, and MAP2K1.
CCTeta, a novel soluble guanylyl cyclase-interacting protein.
GeneRIF
Murad et al., Houston, United States. In J Biol Chem, 2004
CCTeta is a novel soluble guanylyl cyclase-interacting protein [CCTeta]
Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle.
GeneRIF
Kubota et al., Kyoto, Japan. In Eur J Biochem, 2001
Functional characterization of the CCT complex and its subunits in mouse.
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