Computerized analysis of fetal heart rate variability signal during the stages of labor.
Napoli, Italy. In J Obstet Gynaecol Res, Feb 2016
AIM: To analyze computerized cardiotocographic (cCTG) parameters (baseline fetal heart rate, baseline FHR; short term variability, STV; approximate entropy, ApEn; low frequency, LF; movement frequency, MF; high frequency, HF) in physiological pregnancy in order to correlate them with the stages of labor.
Integrated analysis of gene expression and genomic aberration data in osteosarcoma (OS).
Chongqing, China. In Cancer Gene Ther, Nov 2015
Comparing genomic aberrations and DGEs, we found 41 SNP-associated DEGs and 124 CNV-associated DEGs, in which 7 DGEs were associated with both SNPs and CNVs, including WWP1, EXT1, LDHB, C8orf59, PLEKHA5, CCT3 and VWF.
Muscle wasting in myotonic dystrophies: a model of premature aging.
San Sebastián, Spain. In Front Aging Neurosci, 2014
The underlying molecular disorder in DM1 consists of the existence of a pathological (CTG) triplet expansion in the 3' untranslated region (UTR) of the Dystrophia Myotonica Protein Kinase (DMPK) gene, whereas (CCTG)n repeats in the first intron of the Cellular Nucleic acid Binding Protein/Zinc Finger Protein 9 (CNBP/ZNF9) gene cause DM2.
RNA-mediated neuromuscular disorders.
Minneapolis, United States. In Annu Rev Neurosci, 2005
The identification and characterization of RNA-binding proteins that interact with expanded CUG repeats and the discovery that a similar transcribed but untranslated CCTG expansion in an intron causes myotonic dystrophy type 2 (DM2) have uncovered a new type of mechanism in which microsatellite expansion mutations cause disease through an RNA gain-of-function mechanism.