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Chaperonin containing TCP1, subunit 4

CCT4, CCTdelta, ANC2
The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: TRIC, Actin, CCT2, CCT5, ACID
Papers on CCT4
Over-Expression Analysis of All Eight Subunits of the Molecular Chaperone CCT in Mammalian Cells Reveals a Novel Function for CCTdelta.
New
Grantham et al., Stockholm, Sweden. In J Mol Biol, Sep 2015
Expression of the equivalent subunit in yeast, GFP-Cct4, rescues growth of the temperature-sensitive strain cct4-1 at the non-permissive temperature, indicative of conserved subunit-specific activities for CCTdelta.
Silencing of long noncoding RNA MALAT1 by miR-101 and miR-217 inhibits proliferation, migration, and invasion of esophageal squamous cell carcinoma cells.
New
Yang et al., Beijing, China. In J Biol Chem, Mar 2015
This might be attributed to the deregulation of downstream genes of MALAT1, such as MIA2, HNF4G, ROBO1, CCT4, and CTHRC1.
Biochemical characterization of mutants in chaperonin proteins CCT4 and CCT5 associated with hereditary sensory neuropathy.
King et al., Cambridge, United States. In J Biol Chem, 2014
C450Y CCT4 was identified in a stock of Sprague-Dawley rats, whereas H147R CCT5 was found in a human Moroccan family.
Human CCT4 and CCT5 chaperonin subunits expressed in Escherichia coli form biologically active homo-oligomers.
King et al., Cambridge, United States. In J Biol Chem, 2013
CCT4 and CCT5, but not the other six CCT subunits, formed high molecular weight complexes within the E. coli cells that sedimented about 20S in sucrose gradients.
Serum antibody response to group II chaperonin from Methanobrevibacter oralis and human chaperonin CCT.
Takashiba et al., Okayama, Japan. In Pathog Dis, 2013
In comparison with healthy controls, periodontitis patients showed significantly higher responses to CCT4 and CCT8 on dot blot analysis.
Analyzing microarray data of Alzheimer's using cluster analysis to identify the biomarker genes.
Gumpeny et al., Vishākhapatnam, India. In Int J Alzheimers Dis, 2011
Three genes, SORL1, APP, and APOE, are suspected to cause Alzheimer's whereas the other 21 genes are related to other diseases but may also be found to be associated with Alzheimer's, and these are TMEM59, CCT4, IGF2R, SFPQ, PRDX3, RNF14, IDS, SSBP1, SYNE2, TXNL4A, STXBP3, SMARCB1, ULK2, AGTPBP1, FABP7, CALB1, H2AFY, COPA, SAP18, ATIC and SYNCRIP.
MALAT-1 enhances cell motility of lung adenocarcinoma cells by influencing the expression of motility-related genes.
Akimitsu et al., Tokyo, Japan. In Febs Lett, 2010
In these genes, knockdown of any one of CTHRC1, CCT4, HMMR, or ROD1 clearly inhibited cell migration.
CCTalpha and CCTdelta chaperonin subunits are essential and required for cilia assembly and maintenance in Tetrahymena.
Soares et al., Portugal. In Plos One, 2009
METHODOLOGY/PRINCIPAL FINDINGS: We disrupted the genes encoding CCTalpha and CCTdelta subunits in the ciliate Tetrahymena.
Screening for genetic abnormalities involved in ovarian carcinogenesis using retroviral expression libraries.
Suzuki et al., Tochigi, Japan. In Int J Oncol, 2009
As a result, proteasome subunit beta-type 2 (PSMB2), ubiquitin-specific protease 14 (USP14), and keratin 8 (KRT8) were identified from SHIN-3, and polymerase II RNA subunit (POLR2E), chaperonin containing T-complex polypeptide 1 subunit 4 (CCT4), glia maturation factor beta (GMFB), and neuroblastoma ras viral oncogene homolog (NRAS) from TYK-CPr.
Translation termination and protein folding pathway genes are not correlated in gastric cancer.
Brito et al., Lisbon, Portugal. In Clin Chem Lab Med, 2008
METHODS: Relative expression levels of eRF1, eRF3a/GSPT1, PFDN4, CCT2, CCT4, and TBCA genes in tumour samples relative to their adjacent normal tissues were investigated using real time-polymerase chain reaction in 20 gastric cancer patients.
Overexpressed ribosomal proteins suppress defective chaperonins in Saccharomyces cerevisiae.
Sherman et al., Rochester, United States. In Fems Yeast Res, 2008
We have isolated and characterized 22 multicopy suppressors of the temperature-sensitive allele, cct4-1, which encodes an altered protein with a G345D replacement that diminishes ATP hydrolysis.
ATP-induced allostery in the eukaryotic chaperonin CCT is abolished by the mutation G345D in CCT4 that renders yeast temperature-sensitive for growth.
GeneRIF
Horovitz et al., Israel. In J Mol Biol, 2008
support for the sequential model for ATP-dependent allosteric transitions in CCT
The inter-ring arrangement of the cytosolic chaperonin CCT.
Valpuesta et al., Madrid, Spain. In Embo Rep, 2007
Here, three-dimensional reconstructions generated by cryoelectron microscopy of complexes between CCT and either of two different monoclonal antibodies that react specifically with the CCTepsilon and CCTdelta subunits have been used to determine the phasing between the two chaperonin rings.
Mutation in the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (Cct5) gene causes autosomal recessive mutilating sensory neuropathy with spastic paraplegia.
Yahyaoui et al., Rabat, Morocco. In J Med Genet, 2006
In this candidate interval, the Cct5 gene encoding the epsilon subunit of the cytosolic chaperonin-containing t-complex peptide-1 (CCT) was the most obvious candidate gene since mutation in the Cct4 gene encoding the CCT delta subunit has been reported to be associated with autosomal recessive mutilating sensory neuropathy in mutilated foot (mf) rat mutant.
Cutaneous and sympathetic denervation in neonatal rats with a mutation in the delta subunit of the cytosolic chaperonin-containing t-complex peptide-1 gene.
GeneRIF
Hsieh et al., Taipei, Taiwan. In Neurobiol Dis, 2004
the mutation in Cct4 underlies cutaneous nerve degeneration in mutilated-foot rats.
Eukaryotic type II chaperonin CCT interacts with actin through specific subunits.
Impact
Valpuesta et al., Madrid, Spain. In Nature, 2000
Immunolabelling of CCT-substrate complexes with antibodies against two specific CCT subunits showed that actin binds to CCT using two specific and distinct interactions: the small domain of actin binds to CCTdelta and the large domain to CCTbeta or CCTepsilon (both in position 1,4 with respect to delta).
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