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Chaperonin containing TCP1, subunit 2

CCT2, CCTbeta, Cctb, BIN3, Pcyt1b
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] (from NCBI)
Top mentioned proteins: TRIC, Actin, CAN, CCT5, ACID
Papers on CCT2
Two members of the TRiC chaperonin complex, CCT2 and TCP1 are essential for survival of breast cancer cells and are linked to driving oncogenes.
New
Ethier et al., Charleston, United States. In Exp Cell Res, Apr 2015
Using this approach, we identified two genes, TCP1 and CCT2, as being recurrently altered in breast cancer, necessary for growth/survival of breast cancer cells in vitro, and determinants of overall survival in breast cancer patients.
Transgenic Arabidopsis flowers overexpressing acyl-CoA-binding protein ACBP6 are freezing tolerant.
Chye et al., Hong Kong, Hong Kong. In Plant Cell Physiol, 2014
ACBP6-conferred freezing-tolerant flowers showed induction of COR-related genes, CBF genes and ICE1, PC-related genes (PLDδ, CK, CK-LIKE1, CK-LIKE2, CCT1, CCT2, LPCAT1, PLA2α, PAT-PLA-IIβ, PAT-PLA-IIIα, PAT-PLA-IIIδ and PLDζ2), MGDG-related genes (MGD genes and SFR2) and ABA-responsive genes.
Changes in granulosa cells gene expression associated with growth, plateau and atretic phases in medium bovine follicles.
Sirard et al., Québec, Canada. In J Ovarian Res, 2013
On the other hand, the A vs. P contrast showed up-regulation of multiple transcripts associated to apoptosis: CCT2, DAB2, DSG2 and TGM2.
Shigella flexneri infection in Caenorhabditis elegans: cytopathological examination and identification of host responses.
Verma et al., Canberra, Australia. In Plos One, 2013
Four of the identified genes, aco-1, cct-2, daf-19 and hsp-60, were knocked down using RNAi and ACO-1, CCT-2 and DAF-19, which were identified as up-regulated in response to S. flexneri infection, were found to be involved in the infection process.
The N-BAR domain protein, Bin3, regulates Rac1- and Cdc42-dependent processes in myogenesis.
Pavlath et al., Atlanta, United States. In Dev Biol, 2013
Here, we identify novel functions for the N-BAR domain protein, Bridging integrator 3 (Bin3), during myogenesis in mice.
Clinicopathological features and CCT2 and PDIA2 expression in gallbladder squamous/adenosquamous carcinoma and gallbladder adenocarcinoma.
Chen et al., In World J Surg Oncol, 2012
METHODS: We examined the expression levels of CCT2 and PDIA3 by immunohistochemistry (IHC) staining in human GBC tissue samples collected from 46 patients with SC/ASC and evaluated the clinicopathological significance of both CCT2 and PDIA3 expression in the SC/ASC subtypes of GBC by Kaplan-Meier analysis and multivariate Cox regression analysis.
The Bin3 RNA methyltransferase targets 7SK RNA to control transcription and translation.
Review
Hanes et al., Syracuse, United States. In Wiley Interdiscip Rev Rna, 2012
Bicoid-interacting protein 3 (Bin3) is a conserved RNA methyltransferase found in eukaryotes ranging from fission yeast to humans.
Can diet combined with treatment scheduling achieve consistency of rectal filling in patients receiving radiotherapy to the prostate?
Dearnaley et al., United Kingdom. In Radiother Oncol, 2011
Two subsequent CT scans were acquired at 7 (CCT1) and 10 days (CCT2) after SCT at a similar time.
Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A.
Floros et al., United States. In Proteome Sci, 2011
These include major vault protein, chaperonin subunit 2 (beta) (CCT2), and Rho GDP alpha dissociation inhibitor.
Clinical validity of the children's category test-level 2 in a mixed sample of school-aged children.
Morris et al., Chicago, United States. In Arch Clin Neuropsychol, 2011
Thus, to explore the clinical validity of the widely used CCT-Level 2 (CCT-2) version, results of that test were analyzed post hoc in a sample of 265 children with mixed etiology referred for neuropsychological testing at a private outpatient laboratory.
Involvement of F-actin in chaperonin-containing t-complex 1 beta regulating mouse mesangial cell functions in a glucose-induction cell model.
GeneRIF
Lin et al., Taipei, Taiwan. In Exp Diabetes Res, 2010
role of chaperonin-containing t-complex polypeptide 1 beta (CCT2) in the regulation of mesangial cell contraction, proliferation, and migration with filamentous/globular-(F/G-) actin ratio under high glucose induction
Association of the influenza virus RNA polymerase subunit PB2 with the host chaperonin CCT.
GeneRIF
Fodor et al., Oxford, United Kingdom. In J Virol, 2010
PB2 associates with CCT2 as a monomer and the CCT binding site is located in a central region of the PB2 protein.
Isozyme-specific modes of activation of CTP:phosphorylcholine cytidylyltransferase in Arabidopsis thaliana at low temperature.
GeneRIF
Nishida et al., Tokyo, Japan. In Plant Cell Physiol, 2009
The CDP-choline pathway of A. thaliana is up-regulated at low temperature via isogene-specific modes: enhanced expression of CCT2 and post-translational activation/inactivation of CCT1 in membranes.
p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling.
GeneRIF
Blenis et al., Boston, United States. In J Biol Chem, 2009
The chaperonin CCT is identified as a novel physiological substrate for p90 ribosomal S6 kinase (RSK) and p70 ribosomal S6 kinase (S6K).
BAR the door: cancer suppression by amphiphysin-like genes.
Review
Chang et al., United States. In Biochim Biophys Acta, 2009
The evolutionarily conserved amphiphysin-like genes Bin1 and Bin3 function in membrane and actin dynamics, cell polarity, and stress signaling.
Identification and characterization of the nuclear isoform of Drosophila melanogaster CTP:phosphocholine cytidylyltransferase.
GeneRIF
Friesen et al., Normal, United States. In Biochemistry, 2008
CCT2 was identified as the cytoplasmic isoform.
Spatial regulation of Cdc42 during cytokinesis.
Review
Perez et al., Salamanca, Spain. In Cell Cycle, 2007
We discuss here how Hob3, a BAR domain containing protein similar to human BIN3 and S. cerevisiaeRsv161, may be required to recruit Cdc42 to the cell division site as well as for the activation of this GTPase mediated by Gef1.
The C termini of Arabidopsis cryptochromes mediate a constitutive light response.
Impact
Cashmore et al., Philadelphia, United States. In Cell, 2000
On fusion with beta-glucuronidase (GUS), both the Arabidopsis CRY1 C-terminal domain (CCT1) and the CRY2 C-terminal domain (CCT2) mediate a constitutive light response.
Eukaryotic type II chaperonin CCT interacts with actin through specific subunits.
Impact
Valpuesta et al., Madrid, Spain. In Nature, 2000
Immunolabelling of CCT-substrate complexes with antibodies against two specific CCT subunits showed that actin binds to CCT using two specific and distinct interactions: the small domain of actin binds to CCTdelta and the large domain to CCTbeta or CCTepsilon (both in position 1,4 with respect to delta).
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