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Chemokine binding protein 2

CCR9, CCR10, D-6
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, CD4, CD8, ACID, V1a
Papers on CCR9
Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses.
New
Mehandru et al., New York City, United States. In J Exp Med, Feb 2016
After intranasal immunization with inactive cholera toxin (CT), LDCs stimulated retinoic acid-dependent up-regulation of α4β7 and CCR9 gut-homing receptors on local IgA-expressing B cells.
Selective programming of CCR10(+) innate lymphoid cells in skin-draining lymph nodes for cutaneous homeostatic regulation.
New
Impact
Xiong et al., United States. In Nat Immunol, Jan 2016
Here we found that under steady-state conditions, ILCs in skin-draining lymph nodes (sLNs) were continuously activated to acquire regulatory properties and high expression of the chemokine receptor CCR10 for localization into the skin.
Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis.
New
Hackam et al., In J Clin Invest, Jan 2016
The intestinal expression of the lipopolysaccharide receptor TLR4, which is higher in the premature compared with full-term human and mouse intestine, is required for lymphocyte influx through TLR4-mediated upregulation of CCR9/CCL25 signaling.
Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets.
Review
New
Thelen et al., Haifa, Israel. In J Leukoc Biol, Jan 2016
They include the CXCR3 ligands CXCL9 and CXCL10, the CCR2 ligand CCL2, all 3 CCR5 ligands, and the CCR9 ligand CCL25.
The Role of Chemokines in Mesenchymal Stem Cell Homing to Wounds.
Review
New
Hocking, Seattle, United States. In Adv Wound Care (new Rochelle), Dec 2015
To date, the most studied chemokine-chemokine receptor axis in MSC homing to wounds is CXCL12-CXCR4 but recent work suggests that CCL27-CCR10 and CCL21-CCR7 may also be involved.
Where are we heading to in pharmacological IBD therapy?
Review
New
Rogler, Zürich, Switzerland. In Pharmacol Res, Oct 2015
Some initially promising therapies will need further development or have failed such as Trichuris suis ova therapy (but not helminth therapy in general), CCR9 targeted therapies or recombinant IL-10.
Potential for use of retinoic acid as an oral vaccine adjuvant.
Review
New
Kelly et al., Lusaka, Zambia. In Philos Trans R Soc Lond B Biol Sci, Jul 2015
Increased expression of α4β7 integrin and the chemokine receptor CCR9 following exposure to ATRA can be used to redirect T cells to the gut.
Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting.
New
Impact
Lipkin et al., Ithaca, United States. In Nat Biotechnol, Jun 2015
We engineered use of the chemokine receptor CCR9 in CRC cell lines and patient-derived cells to create primary gastrointestinal (GI) tumors in immunodeficient mice by tail-vein injection rather than surgery.
Next-Generation Therapeutics for IBD.
Review
New
D'Haens et al., Amsterdam, Netherlands. In Curr Gastroenterol Rep, Jun 2015
Other therapeuticals that might find their way to the market the coming years include the anti-mucosal vascular addressin cell adhesion molecule (MAdCAM) PF-00547659, small molecules (including laquinimod and the CCR9 antagonist Vercirnon), as well as an orally active SMAD7 antisense oligonucleotide that showed clinical benefit in Crohn's disease patients.
The abnormal expression of CCR4 and CCR6 on Tregs in rheumatoid arthritis.
Han et al., Shanghai, China. In Int J Clin Exp Med, 2014
CCR7 or CCR9 expression on Tregs from spleen and dLN of either normal or CIA mice was undetectable.
CCR6(+) Th cell populations distinguish ACPA positive from ACPA negative rheumatoid arthritis.
Lubberts et al., Rotterdam, Netherlands. In Arthritis Res Ther, 2014
Similar proportions of CCR4(+) and CCR10(+) Th cells were found.
The Differential Expression and Function of the Inflammatory Chemokine Receptor CXCR5 in Benign Prostatic Hyperplasia and Prostate Cancer.
Wei et al., Chengdu, China. In Int J Med Sci, 2014
RESULTS: RESULTS of gene-chips indicated that there was low or no expression of CCR10, CXCR1, CXCR3 and CXCR5 in BPH-1 cells, whereas the expression of these receptors in BPH-1 cells was increased by PBMCs, and the expression was high in LNCaP cells.
C-type lectin-like receptor LOX-1 promotes dendritic cell-mediated class-switched B cell responses.
Impact
Oh et al., Dallas, United States. In Immunity, 2014
LOX-1 signaling on DCs licensed the cells to promote B cell differentiation into class-switched plasmablasts and led to downregulation of chemokine receptor CXCR5 and upregulation of chemokine receptor CCR10 on plasmablasts, enabling their exit from germinal centers and migration toward local mucosa and skin.
PTEN action in leukaemia dictated by the tissue microenvironment.
Impact
Lowe et al., New York City, United States. In Nature, 2014
Leukaemia infiltration into the intestine was dependent on CCR9 G-protein-coupled receptor signalling, which was amplified by PTEN loss.
The chemokine decoy receptor D6 prevents excessive inflammation and adverse ventricular remodeling after myocardial infarction.
GeneRIF
Silvestre et al., Paris, France. In Arterioscler Thromb Vasc Biol, 2012
Chemokine decoy receptor D6 limits CC-chemokine-dependent pathogenic inflammation and is required for adequate cardiac remodeling after myocardial infarction.
CCL27-CCR10 and CXCL12-CXCR4 chemokine ligand-receptor mRNA expression ratio: new predictive factors of tumor progression in cutaneous malignant melanoma.
GeneRIF
Pellín et al., Valencia, Spain. In Clin Exp Metastasis, 2012
low CCL27/CCR10 and CXCL12/CXCR4 intratumoral mRNA ratios are associated with melanoma progression
CCR9+ T cells contribute to the resolution of the inflammatory response in a mouse model of intestinal amoebiasis.
GeneRIF
García-Zepeda et al., Mexico. In Immunobiology, 2012
Data show that chemokine receptor CCR9(-/-) knockout mice developed a chronic inflammatory response with over-expression of the cytokines and chemokines.
Control of murine Ly6C(high) monocyte traffic and immunosuppressive activities by atypical chemokine receptor D6.
GeneRIF
Bonecchi et al., Milano, Italy. In Blood, 2012
control of CCR2 ligands by D6 regulates the traffic of Ly6C(high) monocytes and controls their immunosuppressive potential.
Overexpression of the chemokine receptors CXCR4, CCR7, CCR9, and CCR10 in human primary cutaneous melanoma: a potential prognostic value for CCR7 and CCR10?
GeneRIF
Weinlich et al., Innsbruck, Austria. In Arch Dermatol Res, 2012
CCR7 overexpression correlated with expression of metallothionein, while CCR10 was associated with cerebral metastases. CCR7 and CCR10 overexpressions were associated with a worse outcome independent of Breslow's tumor thickness and Clark level.
Plasmacytoid dendritic cells transport peripheral antigens to the thymus to promote central tolerance.
Impact
Butcher et al., Stanford, United States. In Immunity, 2012
Immature plasmacytoid DCs (pDCs) express CCR9, a chemokine receptor involved in migration of T cell precursors to the thymus.
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