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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Crystallin, gamma D

CCP, gammaD-crystallin, CCP1
Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, C-reactive protein, AGE, IgM
Papers on CCP
The Matrix Proteins Hasp and Hig Exhibit Segregated Distribution within Synaptic Clefts and Play Distinct Roles in Synaptogenesis.
New
Hama et al., Kyoto, Japan. In J Neurosci, Feb 2016
In this study, we identified Hasp, a Drosophila secretory protein containing CCP and WAP domains.
Evidence for new C-terminally truncated variants of α- and β-tubulins.
New
Marie-Jo et al., Grenoble, France. In Mol Biol Cell, Feb 2016
This truncated α1A/B-tubulin variant can be generated from αΔ2-tubulin by the deglutamylases CCP1, CCP4, CCP5, CCP6, but not by CCP2 and CCP3.
Mutations in complement factor H impair alternative pathway regulation on mouse glomerular endothelial cells in vitro.
New
van der Vlag et al., Netherlands. In J Biol Chem, Feb 2016
UNASSIGNED: Complement factor H (FH) inhibits complement activation and interacts with glomerular endothelium via its complement control protein (CCP) domains 19-20, which also recognize heparan sulfate (HS).
C4b-binding protein: The good, the bad and the deadly. Novel functions of an old friend.
Review
New
Blom et al., Malmö, Sweden. In Immunol Lett, Jan 2016
It consists of several identical 75kDa α-chains and often also one 40kDa β-chain, both of which are mainly composed of complement control protein (CCP) domains.
Early phase clinical and biological markers associated with subclinical atherosclerosis measured at 7 years of evolution in an early inflammatory arthritis cohort.
New
Vittecoq et al., Rouen, France. In Clin Exp Rheumatol, Jan 2016
In contrast, anti-CCP positivity (>50 UA/ml) was associated with thinner cIMT (p=0.03).
Structure and Function of Transient Encounters of Redox Proteins.
Review
New
Impact
Volkov, Brussels, Belgium. In Acc Chem Res, Jan 2016
In particular, this Account focuses on the complex of cytochrome c (Cc) and cytochrome c peroxidase (CcP), which is a paradigm of biomolecular ET and an attractive system for studying protein binding and enzymatic catalysis.
Characterization of a Gene Coding for the Complement System Component FB from Loxosceles laeta Spider Venom Glands.
New
Tambourgi et al., São Paulo, Brazil. In Plos One, Dec 2015
Lox-FB has a classical domain organization composed of a control complement protein domain (CCP), a von Willebrand Factor domain (vWFA), and a serine protease domain (SP).
Expression of VSTM1-v2 Is Increased in Peripheral Blood Mononuclear Cells from Patients with Rheumatoid Arthritis and Is Correlated with Disease Activity.
New
Shi et al., Linyi, China. In Plos One, Dec 2015
The VSTM1-v2 mRNA expression level was positively correlated with IL-17A mRNA expression level, DAS28, CRP and ESR, but was not correlated to RF, Anti-CCP or ANA.
Creating functional sophistication from simple protein building blocks, exemplified by factor H and the regulators of complement activation.
Review
New
Barlow et al., Edinburgh, United Kingdom. In Biochem Soc Trans, Nov 2015
Also known as short consensus repeats (SCRs) or sushi domains each CCP contains approximately 60 amino acid residues, including four consensus cysteines participating in two disulfide bonds.
Follicular helper T cells in rheumatoid arthritis.
Review
New
Li et al., Chengdu, China. In Clin Rheumatol, Sep 2015
Rheumatoid factor (RF) and anticyclic citrullinated peptides (anti-CCP) are biomarkers for the evaluation of RA although their functions in the pathogenesis of RA are poorly understood.
The role of citrullinated protein antibodies in predicting erosive disease in rheumatoid arthritis: a systematic literature review and meta-analysis.
Review
Mackworth-Young et al., London, United Kingdom. In Int J Rheumatol, 2014
All studies carried prognostic data on all available isotypes of anticyclic citrullinated protein (CCP), while four had data on antimutated citrullinated vimentin (MCV).
αTAT1 catalyses microtubule acetylation at clathrin-coated pits.
Impact
Chavrier et al., Paris, France. In Nature, 2013
In migrating cells, the polarized orientation of acetylated microtubules correlates with CCP accumulation at the leading edge, and interaction of αTAT1 with AP2 is required for directional migration.
Validation of a cell-cycle progression gene panel to improve risk stratification in a contemporary prostatectomy cohort.
Impact
Carroll et al., San Francisco, United States. In J Clin Oncol, 2013
PURPOSE: We aimed to validate a previously described genetic risk score, denoted the cell-cycle progression (CCP) score, in predicting contemporary radical prostatectomy (RP) outcomes.
Structure of the haptoglobin-haemoglobin complex.
Impact
Moestrup et al., Århus, Denmark. In Nature, 2012
This structure reveals that haptoglobin molecules dimerize through an unexpected β-strand swap between two complement control protein (CCP) domains, defining a new fusion CCP domain structure.
Structural and biochemical characterization of the childhood cataract-associated R76S mutant of human γD-crystallin.
GeneRIF
Gronenborn et al., Dalian, China. In Biochemistry, 2012
neither structural nor stability changes in the protein are responsible for the R76S gammaD-crystallin variant's association with cataract
Two-dimensional IR spectroscopy and segmental 13C labeling reveals the domain structure of human γD-crystallin amyloid fibrils.
GeneRIF
Zanni et al., Madison, United States. In Proc Natl Acad Sci U S A, 2012
Upon acid-induced amyloid fibril formation, the C-terminal domain forms amyloid beta-sheets, the N-terminal domain becomes extremely disordered but lies near to the beta-sheets. Fibril nucleation & extension occur only in the C-terminal domain.
Cataract-linked γD-crystallin mutants have weak affinity to lens chaperones α-crystallins.
GeneRIF
McHaourab et al., Nashville, United States. In Febs Lett, 2012
mutants and possibly age-damaged gammaD-crystallin can escape quality control by lens chaperones rationalizing the observation that they nucleate protein aggregation and lead to cataract
Cataract-causing defect of a mutant γ-crystallin proceeds through an aggregation pathway which bypasses recognition by the α-crystallin chaperone.
GeneRIF
King et al., Cambridge, United States. In Plos One, 2011
The perturbed conformation of human gamma-crystallin D, I90F mutant, was recognized and bound by both alpha-crystallin A and alpha-crystallin B chaperones.
Prognostic value of an RNA expression signature derived from cell cycle proliferation genes in patients with prostate cancer: a retrospective study.
Impact
Transatlantic Prostate Group et al., London, United Kingdom. In Lancet Oncol, 2011
We assessed the prognostic value of a predefined cell cycle progression (CCP) score in two cohorts of patients with prostate cancer.
Crystalline cataract caused by a heterozygous missense mutation in γD-crystallin (CRYGD).
GeneRIF
Engle et al., Boston, United States. In Mol Vis, 2010
The heterozygous 109C to A CRYGD missense mutation is associated with a distinct crystalline cataract in two US Caucasian pedigrees.
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