What is New in the Management of Epilepsy in Gliomas?
Torino, Italy. In Curr Treat Options Neurol, Jun 2015
Radiotherapy and chemotherapy with alkylating agents (procarbazine, CCNU, vincristine, temozolomide) are effective in reducing the frequency of seizures in patients with pharmacoresistant epilepsy.
Molecular signalling pathways in canine gliomas.
College Station, United States. In Vet Comp Oncol, Apr 2015
Protein expression was defined in three canine astrocytic glioma cell lines treated with CCNU, temozolamide or CPT-11 and was further evaluated in 22 spontaneous gliomas including high and low grade astrocytomas, high grade oligodendrogliomas and mixed oligoastrocytomas.
Predictive biomarkers in adult gliomas: the present and the future.
Lyon, France. In Curr Opin Oncol, 2013
RECENT FINDINGS: The long-term results of the Radiation Therapy Oncology Group and European Organization for Research and Treatment of Cancer trials in anaplastic oligodendroglial glioma have shown that the 1p/19q codeletion predicts an overall survival benefit from early PCV (procarbazine CCNU vincristine) chemotherapy.
NO-mediated chemoresistance in C6 glioma cells.
Saint Louis, United States. In Ann N Y Acad Sci, 2002
We note that increased NO synthesis by cytokine exposure or iNOS overexpression neutralized the cytotoxicity of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU), but not cisplatin, in rat C6 glioma cells.
[Recent advance in chemotherapy for advanced colorectal cancer].
Japan. In Gan To Kagaku Ryoho, 1996
While 5-fluorouracil (5-FU) is a key drug for more than three decades, many a combination chemotherapy with 5-FU and other drugs such as methyl-CCNU, vincristine, streptozocin, mitomycin C and so on has been studied extensively only to show no significant improvement compared with monotherapy with 5-FU.