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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 18 Mar 2014.

CCKBR cholecystokinin B receptor

CCK-B receptor
Top mentioned proteins: Cholecystokinin, Gastrin, ACID, HAD, CCK-4
Papers using CCK-B receptor antibodies
The organization of noradrenergic pathways from the brainstem to the paraventricular and supraoptic nuclei in the rat
Supplier
Železná Blanka et al., In BMC Neuroscience, 1981
... , NeoMPS, Strasbourg, France), CCK-A receptor antagonist devazepide (L364,718) or CCK-B receptor antagonist L365,260 (gift from ML Laboratories, Liverpool, UK) and CART(61-102) (Bachem, Bubendorf, Switzerland) were used ...
Papers on CCK-B receptor
Synthesis, analytical analysis, and medicinal aspect of novel benzimidazoles and their metal complexes.
New
Sharma et al., In Chem Biol Drug Des, Nov 2013
Benzimidazole and their metal analogs that can act as multimodal agent and have non-peptidic CCK-B receptor antagonist were synthesized and characterized on the basis of spectroscopic techniques such as FT-IR, NMR, FAB-MS and also evaluated for biologic efficacy.
Characterization of gastrins and their receptor in solid human gastric adenocarcinomas.
New
Rehfeld et al., Copenhagen, Denmark. In Scand J Gastroenterol, Jun 2013
OBJECTIVE: The gastrin and the gastrin/CCK-B receptor genes are co-expressed in several carcinomas.
Modulation of acetylcholine release by cholecystokinin in striatum: receptor specificity; role of dopaminergic neuronal activity.
Rakovska et al., Sofia, Bulgaria. In Brain Res Bull, 2013
CAM 1028 (10μM), a CCK-B receptor antagonist, also prevented the potentiating effect of CCK-8 (0.01μM) on electrically stimulated release of [(3)H]ACh.
Downregulation of the CCK-B receptor in pancreatic cancer cells blocks proliferation and promotes apoptosis.
Smith et al., United States. In Am J Physiol Gastrointest Liver Physiol, 2012
Gastrin stimulates the growth of pancreatic cancer cells through the activation of the cholecystokinin-B receptor (CCK-BR), which has been found to be overexpressed in pancreatic cancer.
CCK-B receptor gene and response to cholecystokinin-tetrapeptide in healthy volunteers.
Bradwejn et al., Ottawa, Canada. In Peptides, 2012
Given the potential role of the central cholecystokinin receptor (CCKBR) (CT) polymorphism alleles 26 and 27 in PD, the present study attempted to discern if these alleles moderated panicogenic sensitivity to the CCKBR agonist, CCK-tetrapeptide (CCK-4), in healthy volunteers.
Incretin physiology beyond glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: cholecystokinin and gastrin peptides.
Review
Rehfeld, Copenhagen, Denmark. In Acta Physiol (oxf), 2011
For instance, foetal and neonatal islets express significant amounts of gastrin, and human as well as porcine islet cells express the gastrin/CCK-B receptor abundantly.
Gastrin stimulates the VEGF-A promotor in a human colon cancer cell line.
Schmitz et al., Bochum, Germany. In Regul Pept, 2011
Therefore, CCK-B receptor antagonists may represent a treatment strategy in patients with colorectal cancer.
Blocking gastrin and CCK-B autocrine loop affects cell proliferation and apoptosis in vitro.
Xie et al., Guiyang, China. In Mol Cell Biochem, 2010
Gastrin and cholecystokinin-B receptor (CCK-B) were co-expressed in human gastric carcinoma tissues, suggesting that a functional autocrine loop, the gastrin and CCK-B receptor loop, may be presented in gastric cancer cells and play an important role in the pathogenesis and progression of gastric carcinomas.
Cholecystokinin-8 antagonizes electroacupuncture analgesia through its B receptor in the caudate nucleus.
Xu et al., Harbin, China. In Neuromodulation, 2010
The present study examined the antagonistic effects of the intracerebral ventricular injection of CCK-8 on EA analgesia and reversing effects of CCK-B receptor antagonist (L-365,260) injection into the caudate nucleus on CCK-8.
An expedient route to a potent gastrin/CCK-B receptor antagonist (+)-AG-041R.
Iwabuchi et al., Sendai, Japan. In J Org Chem, 2009
An enantiocontrolled synthesis of (+)-AG-041R (1), a potent gastrin/CCK-B receptor antagonist, has been achieved employing a chiral rhodium(II)-catalyzed, oxidative intramolecular aza-spiroannulation as the key step.
The biology of cholecystokinin and gastrin peptides.
Review
Hansen et al., Copenhagen, Denmark. In Curr Top Med Chem, 2006
Cholecystokinin (CCK) and gastrin together constitute a family of homologous peptide hormones, which are both physiological ligands for the gastrin/CCK-B receptor, whereas the CCK-A receptor binds only sulfated CCK-peptides.
Peptide receptor radionuclide therapy.
Review
De Jong et al., Rotterdam, Netherlands. In Ann N Y Acad Sci, 2004
For PRRT of CCK-B receptor-positive tumors, such as medullary thyroid carcinoma, radiolabeled minigastrin analogues currently are being successfully applied.
Cholecystokinin: possible mediator of fever and hypothermia.
Review
Pétervári et al., Pécs, Hungary. In Front Biosci, 2004
Central microinjection of CCK in rats induces a thermogenic response that can be attenuated by CCK-B receptor antagonists, but some authors observed a hypothermia.
Radiolabeling approaches for cholecystokinin B receptor imaging.
Review
Salvatore et al., Napoli, Italy. In Biopolymers, 2001
In particular, cholecystokinin (CCK) receptors of the subtype B (CCK-BR) have been shown to be overexpressed in certain neuroendocrine tumors including medullary thyroid cancer.
Central inhibitory dysfunctions: mechanisms and clinical implications.
Impact
Xu et al., Huddinge, Sweden. In Behav Brain Sci, 1997
Furthermore, CI 988, an antagonist of the CCK-B receptor, chronically coadministered with morphine, reduces autotomy, a behavior that may be a sign of neuropathic pain following peripheral nerve section.
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