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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

PTK7 protein tyrosine kinase 7

CCK-4, PTK7
Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack detectable catalytic tyrosine kinase activity but retain roles in signal transduction. The protein encoded by this gene is a member of this subgroup of tyrosine kinases and may function as a cell adhesion molecule. This gene is thought to be expressed in colon carcinomas but not in normal colon, and therefore may be a marker for or may be involved in tumor progression. Four transcript variants encoding four different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cholecystokinin, HAD, ACID, CAN, Gastrin
Papers using CCK-4 antibodies
Regulation of p53 stability and function in HCT116 colon cancer cells.
Supplier
Zhou Zhongjun, In PLoS ONE, 2003
... Antibody against PTK7 was from Abnova.
Papers on CCK-4
Metabotropic glutamate2/3 receptor agonism facilitates autonomic recovery after pharmacological panic challenge in healthy humans.
New
Kellner et al., Hamburg, Germany. In Int Clin Psychopharmacol, Feb 2016
Using a double-blind, randomized placebo-controlled, cross-over study design, we investigated the influence of a 1-week treatment with the mGluR2/3 agonist LY544344, prodrug of LY354740, on autonomic reactivity to a cholecystokinin tetrapeptide (CCK-4) panic challenge in eight healthy young men.
The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway.
New
Borg et al., Marseille, France. In J Biol Chem, Jan 2016
Among WNT/PCP components, protein tyrosine kinase 7 (PTK7) is a tyrosine kinase receptor with poorly defined functions lacking catalytic activity.
Thymic Function Is Most Severely Impaired in Chronic HIV-1 Infection, but Individuals With Faster Disease Progression During Early HIV-1 Infection Expressed Lower Levels of RTEs.
New
Shang et al., Shenyang, China. In J Acquir Immune Defic Syndr, Jan 2016
We measured the peripheral blood levels of T-cell receptor rearrangement excision circles and PTK7 and CD31 expressions for the frequency of circulating recent thymic emigrants.
Isolation of Human Colon Stem Cells Using Surface Expression of PTK7.
New
Batlle et al., Barcelona, Spain. In Stem Cell Reports, Jan 2016
Protein tyrosine pseudokinase PTK7 specified a cell population within human colonic organoids characterized by highest self-renewal and re-seeding capacity.
Quantitative profiling of protein tyrosine kinases in human cancer cell lines by multiplexed parallel reaction monitoring assays.
New
Liebler et al., United States. In Mol Cell Proteomics, Jan 2016
For example, acquired resistance to erlotinib in the 11-18 cell model was associated not only with previously reported upregulation of MET, but also with upregulation of FLK2 and downregulation of LYN and PTK7.
Role of the planar cell polarity gene Protein tyrosine kinase 7 in neural tube defects in humans.
New
Kibar et al., Montréal, Canada. In Birth Defects Res A Clin Mol Teratol, Dec 2015
Protein tyrosine kinase 7 (Ptk7) was shown to cause a very severe form of NTDs called craniorachischisis in a mouse model and genetically interacts with a core PCP member Vangl2 where double heterozygotes suffer from spina bifida.
Quantitative profiling of protein tyrosine kinases in human cancer cell lines by multiplexed parallel reaction monitoring assays.
New
Liebler et al., United States. In Mol Cell Proteomics, Oct 2015
For example, acquired resistance to erlotinib in the 11-18 cell model was associated not only with previously reported upregulation of MET, but also with upregulation of FLK2 and downregulation of LYN and PTK7.
A PTK7/Ror2 Co-Receptor Complex Affects Xenopus Neural Crest Migration.
Borchers et al., Marburg an der Lahn, Germany. In Plos One, 2014
PTK7 (protein tyrosine kinase 7) is a transmembrane pseudokinase and a known regulator of Wnt/PCP signaling, which is expressed in Xenopus neural crest cells and required for their migration.
Axon guidance and injury-lessons from Wnts and Wnt signaling.
Review
Zou et al., San Diego, United States. In Curr Opin Neurobiol, 2014
With 19 Wnts and 14 known receptors (10 Frizzleds (Fzds), Ryk, Ror1/2 and PTK7), the Wnt family signaling proteins contribute significantly to the wiring specificity of the complex brain and spinal cord circuitry.
A consideration of the evidence that genetic defects in planar cell polarity contribute to the etiology of human neural tube defects.
Review
Harris et al., Vancouver, Canada. In Birth Defects Res A Clin Mol Teratol, 2012
Rare putative mutations in the PCP genes VANGL2, SCRIB, DACT1, and CELSR1 cumulatively contributed to over 20% of cases with craniorachischisis, a rare defect; no contributing variants were found for PRICKLE1 or PTK7.
Neuronal network of panic disorder: the role of the neuropeptide cholecystokinin.
Review
Bradwejn et al., Münster, Germany. In Depress Anxiety, 2012
In humans, administration of CCK-4 reliably provokes panic attacks, which can be blocked by antipanic medication.
The many roles of PTK7: a versatile regulator of cell-cell communication.
Review
Borchers et al., Göttingen, Germany. In Arch Biochem Biophys, 2012
PTK7 (protein tyrosine kinase 7) is an evolutionarily conserved transmembrane receptor with functions in various processes ranging from embryonic morphogenesis to epidermal wound repair.
The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells.
GeneRIF
Lee et al., Seoul, South Korea. In J Biol Chem, 2012
a novel role for PTK7 in the tumorigenesis via generation of PTK7-CTF2 by sequential cleavage of ADAM17 and gamma-secretase.
PTK7 regulates myosin II activity to orient planar polarity in the mammalian auditory epithelium.
GeneRIF
Lu et al., Charlottesville, United States. In Curr Biol, 2012
acts in conjunction with the noncanonical Wnt pathway to orient epithelial planar cell polarity through modulation of myosin II-based contractile tension between supporting cells and hair cells
Potential relation of aberrant proteolysis of human protein tyrosine kinase 7 (PTK7) chuzhoi by membrane type 1 matrix metalloproteinase (MT1-MMP) to congenital defects.
GeneRIF
Strongin et al., Los Angeles, United States. In J Biol Chem, 2011
aberrations in the membrane type 1 matrix metalloproteinase/PTK7 axis are detrimental to cell movements that shape the body plan
PTK7: a cell polarity receptor with multiple facets.
GeneRIF
Borg et al., Marseille, France. In Cell Cycle, 2011
The tyrosine kinase receptor, PTK7, is implicated in beta-catenin-dependent developmental processes.
Cdx mediates neural tube closure through transcriptional regulation of the planar cell polarity gene Ptk7.
GeneRIF
Lohnes et al., Ottawa, Canada. In Development, 2011
These findings illustrate a novel and pivotal role for Cdx function upstream of Ptk7 and neural tube closure in vertebrates.
Experimental panic provocation in healthy man-a translational role in anti-panic drug development?
Review
Kellner, Hamburg, Germany. In Dialogues Clin Neurosci, 2010
Most such studies in healthy volunteers have been performed using a cholecystokinin tetrapeptide (CCK-4) challenge.
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates.
Impact
GeneRIF
Tessier-Lavigne et al., Stanford, United States. In Nature, 2004
a mutation disrupts neural tube closure and stereociliary bundle orientation, and shows genetic interactions with a mutation in the mouse Van Gogh homologue vangl2
Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction.
Impact
Mitsudomi et al., Nagoya, Japan. In J Clin Oncol, 2004
Next, we tried to identify a smaller number of genes of particular predictive value, and eight genes (PTK7, CIT, SCNN1A, PGES, ERO1L, ZWINT, and two ESTs) were selected.
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