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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Coiled-coil and C2 domain containing 1B

CC2D1B
Top mentioned proteins: CC2D1A, 5-HT1A, Snf7, SET, galectin-1
Papers on CC2D1B
The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling.
New
Klein et al., Düsseldorf, Germany. In Plos Genet, Dec 2015
CC2D1A and CC2D1B belong to the evolutionary conserved Lgd protein family with members in all multi-cellular animals.
Serotonin-prefrontal cortical circuitry in anxiety and depression phenotypes: pivotal role of pre- and post-synaptic 5-HT1A receptor expression.
Review
Luckhart et al., Ottawa, Canada. In Front Behav Neurosci, 2013
We identify a set of conserved transcription factors including Deaf1, Freud-1/CC2D1A, Freud-2/CC2D1B and glucocorticoid receptors that may confer deleterious regional changes in 5-HT1A receptors in depression, and how future treatments could target these mechanisms.
CC2D1A is a regulator of ESCRT-III CHMP4B.
Weissenhorn et al., Grenoble, France. In J Mol Biol, 2012
We demonstrate that CHMP4B interacts directly with CC2D1A and CC2D1B with nanomolar affinity by forming a 1:1 complex.
Regulation of CHMP4/ESCRT-III function in human immunodeficiency virus type 1 budding by CC2D1A.
Göttlinger et al., Worcester, United States. In J Virol, 2012
We now show that in human cells, CHMP4 proteins are to a considerable extent bound to two high-molecular-weight proteins that we have identified as CC2D1A and CC2D1B.
Freud-2/CC2D1B mediates dual repression of the serotonin-1A receptor gene.
GeneRIF
Albert et al., Ottawa, Canada. In Eur J Neurosci, 2011
data show that Freud-2 is the second component that, with Freud-1, mediates dual repression of the 5-HT1A receptor gene at the dual repressor element.
Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness.
Review
Millar et al., Ottawa, Canada. In Mol Brain, 2010
Extensive characterization of the transcriptional regulation of the 5-HT1A gene (HTR1A) using cell culture systems has revealed a GC-rich "housekeeping" promoter that non-selectively drives its expression; this is flanked by a series of upstream repressor elements for REST, Freud-1/CC2D1A and Freud-2/CC2D1B factors that not only restrict its expression to neurons, but may also regulate the level of expression of 5-HT1A receptors in various subsets of neurons, including serotonergic neurons.
Human Freud-2/CC2D1B: a novel repressor of postsynaptic serotonin-1A receptor expression.
GeneRIF
Albert et al., Ottawa, Canada. In Biol Psychiatry, 2009
Human Freud-2/CC2D1B binds to the 5-HT1A dual repressor element and represses the human 5-HT1A receptor gene to regulate its expression in non-serotonergic cells and neurons.
The Freud-1/CC2D1A family: transcriptional regulators implicated in mental retardation.
Review
Albert et al., Ottawa, Canada. In J Neurosci Res, 2007
The CC2D1A gene family consists of two homologous genes, Freud-1/CC2D1A and Freud-2/CC2D1B, that share conserved domains, including several DM14 domains that are specific to this protein family, a C-terminal helix-loop-helix domain, and a C2 calcium-dependent phospholipid binding domain.
The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking.
GeneRIF
Klein et al., Köln, Germany. In Dev Cell, 2006
Paper describes a function of Cc2d1b/Cc2d1a and its Drosophila homologue l(2)gd in D.melanogaster in Notch trafficking.
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