Stress-induced alterations in 5-HT1A receptor transcriptional modulators NUDR and Freud-1.
Kraków, Poland. In Int J Neuropsychopharmacol, 2014
The effect of stress on the mRNA and protein level of the 5-HT1A receptor and two of its key transcriptional modulators, NUDR and Freud-1, was examined in the prefrontal cortex (PFC) and hippocampus (Hp) using rodent models: olfactory bulbectomy (OB) and prenatal stress (PS) in male and female rats; chronic mild stress in male rats (CMS) and pregnancy stress.
Computational analysis of TRAPPC9: candidate gene for autosomal recessive non-syndromic mental retardation.
Rāwalpindi, Pakistan. In Cns Neurol Disord Drug Targets, 2013
To date, a few genes (PRSS12, CRBN, CC2D1A, GRIK2, TUSC3, TRAPPC9, TECR, ST3GAL3, MED23, MAN1B1, NSUN1) for autosomal-recessive forms of non syndromic MR (NS-ARMR) have been identified and established in various families with ID.
Transcriptional dysregulation of 5-HT1A autoreceptors in mental illness.
Ottawa, Canada. In Mol Brain, 2010
Extensive characterization of the transcriptional regulation of the 5-HT1A gene (HTR1A) using cell culture systems has revealed a GC-rich "housekeeping" promoter that non-selectively drives its expression; this is flanked by a series of upstream repressor elements for REST, Freud-1/CC2D1A and Freud-2/CC2D1B factors that not only restrict its expression to neurons, but may also regulate the level of expression of 5-HT1A receptors in various subsets of neurons, including serotonergic neurons.
The genetics of mental retardation.
Cambridge, United Kingdom. In Hum Mol Genet, 2006
Novel autosomal genes that cause mental retardation have been identified recently including CC2D1A identified by homozygosity mapping.