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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

RB1-inducible coiled-coil 1

CC-1, FIP200, RB1CC1, RB1-inducible coiled-coil 1, CC-I
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009] (from NCBI)
Top mentioned proteins: CAN, Atg1, ACID, AGE, pRb
Papers on CC-1
PSCA acts as a tumor suppressor by facilitating the nuclear translocation of RB1CC1 in esophageal squamous cell carcinoma.
Fu et al., Hong Kong, Hong Kong. In Carcinogenesis, Feb 2016
Further mechanistic studies revealed that RB1CC1, a key signaling node to regulate cellular proliferation and differentiation, interacted specifically with PSCA in ESCC cells.
Atg101: not just an accessory subunit in the autophagy-initiation complex.
Mizushima et al., In Cell Struct Funct, Feb 2016
UNASSIGNED: The Saccharomyces cerevisiae autophagy-initiation complex, Atg1 kinase complex, consists of Atg1, Atg13, Atg17, Atg29, and Atg31, while the corresponding complex in most other eukaryotes, including mammals, is composed of ULK1 (or ULK2), Atg13, FIP200 (also known as RB1CC1), and Atg101.
After Intracerebral Hemorrhage, Oligodendrocyte Precursors Proliferate and Differentiate Inside White-Matter Tracts in the Rat Striatum.
Schlichter et al., Toronto, Canada. In Transl Stroke Res, Feb 2016
Densities of immature OPCs (NG2(+)Olig2(+)) and mature (CC-1(+)Olig2(+)) oligodendrocytes in the peri-hematoma increased dramatically over the first week.
MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells.
Li et al., Jinan, China. In Oncotarget, Jan 2016
In addition, we demonstrated that miR224-3p inhibited autophagy by directly suppressing the expression of two autophagy-related genes (ATGs), ATG5 and FAK family-interacting protein of 200 kDa (FIP200).
Atg13 is essential for autophagy and cardiac development in mice.
Mizushima et al., Tokyo, Japan. In Mol Cell Biol, Jan 2016
Among them, the ULK1 complex, which is composed of ULK1 (or ULK2), FIP200, Atg13, and Atg101, acts at an initial step.
The performance characteristics of prostate-specific antigen and prostate-specific antigen density in Chinese men.
Yiu et al., Hong Kong, Hong Kong. In Asian J Androl, Dec 2015
PSA of 4.5 ng ml-1 had sensitivity of 94.4%, specificity of 14.1%, PPV of 29.5%, and NPV of 86.9%; PSAD of 0.12 ng ml-1 cc-1 had sensitivity of 94.5%, specificity of 26.6%, PPV of 32.8%, and NPV of 92.7%.
Complete Genome Sequence of Spiroplasma cantharicola CC-1T (DSM 21588), a Bacterium Isolated from Soldier Beetle (Cantharis carolinus).
Kuo et al., Taipei, Taiwan. In Genome Announc, 2014
Spiroplasma cantharicola CC-1(T) (DSM 21588) was isolated from the gut of a soldier beetle (Cantharis carolinus) collected in Maryland, USA.
Autophagy in DNA damage response.
Blasiak et al., Łódź, Poland. In Int J Mol Sci, 2014
mTORC1 represses autophagy via phosphorylation of the ULK1/2-Atg13-FIP200 complex thus preventing maturation of pre-autophagosomal structures.
UNC51-like kinase 1, autophagic regulator and cancer therapeutic target.
Ouyang et al., Chengdu, China. In Cell Prolif, 2014
One mammalian homologue of Atg1, UNC-51-like kinase 1 (ULK1) and its related complex ULK1-mAtg13-FIP200 can mediate autophagy under nutrient-deprived conditions, by protein-protein interactions and post-translational modifications.
Autophagy as a regulatory component of erythropoiesis.
An et al., Changsha, China. In Int J Mol Sci, 2014
Here, the modulators of autophagy that regulate erythroid differentiation were summarized, including autophagy-related (Atg) genes, the B-cell lymphoma 2 (Bcl-2) family member Bcl-2/adenovirus E1B 19 kDa interacting protein 3-like (Nix/Binp3L), transcription factors globin transcription factor 1 (GATA1) and forkhead box O3 (FoxO3), intermediary factor KRAB-associated protein1 (KAP1), and other modulators, such as focal adhesion kinase family-interacting protein of 200-kDa (FIP200), Ca2+ and 15-lipoxygenase.
ATG13: just a companion, or an executor of the autophagic program?
Stork et al., Düsseldorf, Germany. In Autophagy, 2014
In vertebrates, the orthologous ULK1 kinase complex contains the Ser/Thr kinase ULK1 and the accessory proteins ATG13, RB1CC1, and ATG101.
Early signalling events of autophagy.
Chan et al., Glasgow, United Kingdom. In Essays Biochem, 2012
In mammalian cells, ATG1 is represented by ULK1 (uncoordinated-51-like kinase 1), which relies on its essential regulatory cofactors mATG13, FIP200 (focal adhesion kinase family-interacting protein 200 kDa) and ATG101.
RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism.
Okabe et al., Ōtsu, Japan. In J Biol Chem, 2012
RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism
Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application.
Okabe et al., Japan. In Plos One, 2011
analysis of preparation of the monoclonal antibody for RB1CC1
Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes.
Overholtzer et al., New York City, United States. In Nat Cell Biol, 2011
These downstream components of the autophagy machinery, but not the upstream mammalian Tor (mTor)-regulated ULK-ATG13-FIP200 complex, facilitate lysosome fusion to single membranes and the degradation of internalized cargo.
RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.
Miyazawa et al., Tokyo, Japan. In J Biol Chem, 2011
RB1CC1 thus appears to play a unique role as a modulator of TGF-beta signaling by restricting substrate specificity of Arkadia.
Suppression of autophagy by FIP200 deletion impairs DNA damage repair and increases cell death upon treatments with anticancer agents.
Guan et al., Ann Arbor, United States. In Mol Cancer Res, 2011
these results identify a new function for FIP200 in the regulation of DNA damage response and cell survival through its activity in autophagy
p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.
Kroemer et al., Paris, France. In Cell Cycle, 2011
p53 regulates autophagy through a direct molecular interaction with RB1CC1/FIP200, a protein that is essential for the very apical step of autophagy initiation.
Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for malignant peritoneal mesothelioma: multi-institutional experience.
Sugarbaker et al., Sydney, Australia. In J Clin Oncol, 2010
completeness of cytoreduction scores of CC-0 or CC-1 (P < .001),
Truncating mutations of RB1CC1 in human breast cancer.
Ikegawa et al., Ōtsu, Japan. In Nat Genet, 2002
RB1CC1 is frequently mutated in breast cancer and shows characteristics of a classical tumor-suppressor gene.
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