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Cerebellin 4 precursor protein

Cbln4, Cerebellin 4
Cerebellin is a sixteen aa peptide found mainly in the adrenal medulla, where it has been shown to have a neuromodulatory function. Cerebellin is derived from precerebellin, a protein with sequence similarity to the noncollagen domain of complement component C1qB. The protein encoded by this gene is a glycoprotein which shares sequence similarity with precerebellin. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Cer, neuroligin-1, lacZ, CD45, DCC
Papers on Cbln4
Cerebellin 4, a synaptic protein, enhances inhibitory activity and resistance of neurons to amyloid-β toxicity.
New
Rodríguez-Tébar et al., Sevilla, Spain. In Neurobiol Aging, Feb 2015
We now show that Hes1 controls the expression of cerebellin 4 (Cbln4), a member of a small family of secreted synaptic proteins, and we present the evidence that Cbln4 plays an essential role in the formation and maintenance of inhibitory GABAergic connections.
Parcellation of cerebellins 1, 2, and 4 among different subpopulations of dorsal horn neurons in mouse spinal cord.
Honig et al., Memphis, United States. In J Comp Neurol, 2014
In contrast, Cbln4 does not form such triads and its function is unknown.
The Cbln family of proteins interact with multiple signaling pathways.
Morgan et al., Memphis, United States. In J Neurochem, 2012
However, GluRδ2 is largely cerebellum-specific, yet Cbln1 and its little studied family members, Cbln2 and Cbln4, are expressed throughout brain.
Cbln family proteins promote synapse formation by regulating distinct neurexin signaling pathways in various brain regions.
Yuzaki et al., Tokyo, Japan. In Eur J Neurosci, 2011
Furthermore, although Cbln1 and its family members Cbln2 and Cbln4 are expressed in brain regions other than the cerebellum, it is unknown whether they regulate synapse formation in these brain regions.
Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons.
Mishina et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2011
Here, we showed that Cbln1 and Cbln2 induced presynaptic differentiation of cultured cortical neurons, while Cbln4 exhibited little activity.
Insulinostatic activity of cerebellin--evidence from in vivo and in vitro studies in rats.
Nowak et al., Berlin, Germany. In Regul Pept, 2009
Four highly homologous isoforms of Cbln are known (Cbln1-Cbln4), which are expressed in the central nervous system (CNS) and in peripheral tissues.
The cerebellin 4 precursor gene is a direct target of SRY and SOX9 in mice.
GeneRIF
Wilhelm et al., Australia. In Biol Reprod, 2009
SRY and SOX9 contribute to the male-specific upregulation of Cbln4 in the developing testis.
Precerebellin-related genes and precerebellin 1 peptide in the adrenal gland of the rat: expression pattern, localization, developmental regulation and effects on corticosteroidogenesis.
Malendowicz et al., Poznań, Poland. In Int J Mol Med, 2009
We also found that, contrary to the human adrenal, in the rat adrenal gland, the Cbln4 gene was not expressed at the mRNA level.
Precerebellin-related genes and precerebellin 1 peptide in endocrine glands of the rat - pattern of their expression.
Malendowicz et al., Poznań, Poland. In Int J Mol Med, 2009
On the contrary, expression of Cbln4 gene was found only in the cerebral cortex.
Expression of precerebellins in cultured rat calvaria osteoblast-like cells.
Malendowicz et al., Poznań, Poland. In Int J Mol Med, 2008
At present 4 propeptides designated as Cbln1, Cbln2, Cbln3 and Cbln4 are recognized.
Cbln and C1q family proteins: new transneuronal cytokines.
Review
Yuzaki, Tokyo, Japan. In Cell Mol Life Sci, 2008
Since other Cbln subfamily members, Cbln2-Cbln4, are expressed in various regions of developing and mature brains, Cbln subfamily proteins may generally serve as a new class of transneuronal regulators of synapse development and synaptic plasticity in various brain regions.
Mapping of Cbln1-like immunoreactivity in adult and developing mouse brain and its localization to the endolysosomal compartment of neurons.
Morgan et al., Memphis, United States. In Eur J Neurosci, 2007
Furthermore, Cbln1 assembles into homomeric complexes and heteromeric complexes with three family members (Cbln2-Cbln4), thereby influencing each other's degradation and secretion.
Characterization of a transneuronal cytokine family Cbln--regulation of secretion by heteromeric assembly.
Yuzaki et al., Tokyo, Japan. In Eur J Neurosci, 2007
Although other Cbln family members, Cbln2-Cbln4, have distinct spatial and temporal patterns of expression throughout the CNS, their biochemical and biological properties have remained largely uncharacterized.
Distinct expression of Cbln family mRNAs in developing and adult mouse brains.
Watanabe et al., Sapporo, Japan. In Eur J Neurosci, 2006
Although Cbln2-Cbln4 are also expressed in the brain and could form heteromeric complexes with Cbln1, their precise expressions remain unclear.
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