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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cas-Br-M

Cbl, c-Cbl
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012] (from NCBI)
Top mentioned proteins: Ubiquitin, CAN, V1a, EGFR, Src
Papers using Cbl antibodies
Androgen-dependent apoptosis in male germ cells is regulated through the proto-oncoprotein Cbl
Supplier
Régnier Daniel C. et al., In The Journal of Cell Biology, 1999
... The anti-Cbl polyclonal antibody directed to the 15 COOH-terminal amino acids of Cbl (C-15) was obtained from Santa Cruz Biotechnology, Inc ...
Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line
Supplier
Kuhn Marina et al., In The Journal of Cell Biology, 1998
... were purchased from the following sources: mAb against TCR ζ-chain and rabbit antibodies (Ab) against CBL were from Santa Cruz Biotechnology, Inc.; Grb2, PLC-γ, p85, ...
T cell receptor ligation induces the formation of dynamically regulated signaling assemblies
Supplier
Samelson Lawrence E. et al., In The Journal of Cell Biology, 1997
... CD43, and CD45 were from Pharmingen; Gads and phosphotyrosine (4G.10) were from UBI; TCRζ, and Cbl were from Santa Cruz Biotechnology, Inc.; SLP-76 was from ...
Papers on Cbl
Different EGF Receptor Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Protein.
New
Pike et al., Washington, D.C., United States. In J Biol Chem, Feb 2016
To determine the basis for these differences, we used luciferase fragment complementation imaging to monitor the recruitment of Cbl, CrkL, Gab1, Grb2, PI3K, p52 Shc, p66 Shc and Shp2 to the EGF receptor when stimulated by the seven EGF receptor ligands.
NADPH oxidase 1 activity and ROS generation are regulated by Grb2/Cbl-mediated proteasomal degradation of NoxO1 in colon cancer cells.
New
Bae et al., South Korea. In Cancer Res, Feb 2016
We found that through the interaction between NoxO1 and growth receptor-bound protein 2 (Grb2), the Casitas B-lineage lymphoma (Cbl) E3 ligase was recruited, leading to decreased NoxO1 stability and a subsequent reduction in ROS generation upon epidermal growth factor (EGF) stimulation.
Timing of the loss of PTEN protein determines disease severity in a mouse model of myeloid malignancy.
New
Emanuel et al., Little Rock, United States. In Blood, Feb 2016
JMML leukemogenesis is linked to a hyperactivated RAS pathway, with driver mutations in the KRAS, NRAS, NF1, PTPN11, or CBL genes.
Myelodysplastic syndromes: Contemporary review and how we treat.
Review
New
Tefferi et al., Rochester, United States. In Am J Hematol, Jan 2016
With the advent of next generation sequencing, recurrent somatic mutations in genes involved in epigenetic regulation (TET2, ASXL1, EZH2, DNMT3A, IDH1/2), RNA splicing (SF3B1, SRSF2, U2AF1, ZRSR2), DNA damage response (TP53), transcriptional regulation (RUNX1, BCOR, ETV6) and signal transduction (CBL, NRAS, JAK2) have been identified in MDS.
Myeloproliferative neoplasms: Current molecular biology and genetics.
Review
New
Saeidi, Kermān, Iran. In Crit Rev Oncol Hematol, Dec 2015
Some other genes' location such as TET oncogene family member 2 (TET2), additional sex combs-like 1 (ASXL1), casitas B-lineage lymphoma proto-oncogene (CBL), isocitrate dehydrogenase 1/2 (IDH1/IDH2), IKAROS family zinc finger 1 (IKZF1), DNA methyltransferase 3A (DNMT3A), suppressor of cytokine signaling (SOCS), enhancer of zeste homolog 2 (EZH2), tumor protein p53 (TP53), runt-related transcription factor 1 (RUNX1) and high mobility group AT-hook 2 (HMGA2) have also identified to be involved in MPNs phenotypes.
The genomic landscape of juvenile myelomonocytic leukemia.
New
Impact
Loh et al., San Francisco, United States. In Nat Genet, Nov 2015
Mutations in NF1, NRAS, KRAS, PTPN11 or CBL occur in 85% of patients, yet there are currently no risk stratification algorithms capable of predicting which patients will be refractory to conventional treatment and could therefore be candidates for experimental therapies.
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
New
Impact
Bastian et al., San Francisco, United States. In Nat Genet, Oct 2015
Instead, other genetic alterations known to activate the MAPK and PI3K signaling cascades were identified in 73% of samples, affecting NF1, CBL, ERBB2, MAP2K1, MAP3K1, BRAF, EGFR, PTPN11, MET, RAC1, SOS2, NRAS and PIK3CA, some of which are candidates for targeted therapies.
Wake-sleep, thermoregulatory, and autonomic effects of cholinergic activation of the lateral hypothalamus in the rat: a pilot study.
New
Amici et al., Bologna, Italy. In Arch Ital Biol, Oct 2015
To this end, the effects of a microinjection of the cholinergic agonist Carbachol (CBL) into the LH were compared to those obtained through the activation of a wider cell population by the microinjection of the GABAA antagonist GABAzine (GBZ).
Gene Expression and Yeast Two-Hybrid Studies of 1R-MYB Transcription Factor Mediating Drought Stress Response in Chickpea (Cicer arietinum L.).
Varshney et al., Hyderābād, India. In Front Plant Sci, 2014
The screening of a root cDNA library with Y2H using the 1R-MYB bait protein, identified three CDS encoding peptides namely, galactinol-sucrose galactosyltransferase 2, CBL (Calcineurin B-like)-interacting serine/threonine-protein kinase 25, and ABA responsive 17-like, which were confirmed by co-transformation in yeast.
Identification of novel pathogenic gene mutations in pediatric acute myeloid leukemia by whole-exome resequencing.
Review
Shiba, In Rinsho Ketsueki, 2014
Many of the recurrent mutations identified in this study involved previously reported targets in AML, such as FLT3, CEBPA, KIT, CBL, NRAS, WT1 and EZH2.
The Role of Crk Adaptor Proteins in T-Cell Adhesion and Migration.
Review
Isakov et al., Beersheba, Israel. In Front Immunol, 2014
They are involved in early steps of lymphocyte activation through their SH2-mediated transient interaction with signal transducing effector molecules, such as Cbl, ZAP-70, CasL, and STAT5.
The Calcium Sensor CBL-CIPK Is Involved in Plant's Response to Abiotic Stresses.
Review
Liu et al., Qingdao, China. In Int J Genomics, 2014
During stress condition, CBL-CIPK complex is identified as a primary element of calcium sensor to perceive environmental signals.
Novel somatic and germline mutations in intracranial germ cell tumours.
Impact
Lau et al., Houston, United States. In Nature, 2014
We find the KIT/RAS signalling pathway frequently mutated in more than 50% of IGCTs, including novel recurrent somatic mutations in KIT, its downstream mediators KRAS and NRAS, and its negative regulator CBL.
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
Impact
Penninger et al., Vienna, Austria. In Nature, 2014
Here we show that genetic deletion of the E3 ubiquitin ligase Cbl-b (casitas B-lineage lymphoma-b) or targeted inactivation of its E3 ligase activity licenses natural killer (NK) cells to spontaneously reject metastatic tumours.
Exome sequencing identifies secondary mutations of SETBP1 and JAK3 in juvenile myelomonocytic leukemia.
Impact
Kojima et al., Nagoya, Japan. In Nat Genet, 2013
Juvenile myelomonocytic leukemia (JMML) is an intractable pediatric leukemia with poor prognosis whose molecular pathogenesis is poorly understood, except for somatic or germline mutations of RAS pathway genes, including PTPN11, NF1, NRAS, KRAS and CBL, in the majority of cases.
Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia.
GeneRIF
Matsubara et al., Sendai, Japan. In Leuk Res, 2012
Casitas B-cell lymphoma mutation in childhood T-cell acute lymphoblastic leukemia.
CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl.
GeneRIF
Liu et al., Houston, United States. In J Immunol, 2012
The CD2-associated adaptor protein (CD2AP)/SH2 domain-containing inositol 5'-phosphatase (SHIP)1 complex and Cbl are recruited to BDCA2 and FcepsilonR1g complex after BDCA2 cross-linking in human primary pDCs.
The Syk-binding ubiquitin ligase c-Cbl mediates signaling-dependent B cell receptor ubiquitination and B cell receptor-mediated antigen processing and presentation.
GeneRIF
Drake et al., Albany, United States. In J Biol Chem, 2012
the novel role for Syk signaling and the Syk-binding ubiquitin ligase c-Cbl in the BCR-mediated processing and presentation of cognate antigen and
Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer.
GeneRIF
Park et al., Montréal, Canada. In J Biol Chem, 2012
Met-dependent Cbl loss may also promote cross-talk through indirect enhancement of EGF receptor signaling.
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
GeneRIF
Huang et al., Glasgow, United Kingdom. In Nat Struct Mol Biol, 2012
Tyr371 phosphorylation activates CBL by inducing linker conformational changes that eliminate autoinhibition, flip the RING domain and E2 into proximity of the substrate-binding site and transform the RING domain into an enhanced E2-binding module.
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