An Introduction to the Endogenous Cannabinoid System.
Bloomington, United States. In Biol Psychiatry, Nov 2015
The most abundant cannabinoid receptors are the CB1 cannabinoid receptors; however, CB2 cannabinoid receptors, transient receptor potential channels, and peroxisome proliferator activated receptors are also engaged by some cannabinoids.
Pregnenolone can protect the brain from cannabis intoxication.
Bordeaux, France. In Science, 2014
The administration of the main active principle of Cannabis sativa (marijuana), Δ(9)-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor.