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Caveolin 2

caveolin-2, Cav-2
The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: caveolin-1, CAN, caveolin-3, HAD, ACID
Papers on caveolin-2
Vascular and autonomic dysregulation in primary open-angle glaucoma.
Review
New
Pasquale, Boston, United States. In Curr Opin Ophthalmol, Jan 2016
Interestingly, common genetic variation in nitric oxide synthase 3 (NOS3) and the caveolin 1/caveolin 2 (CAV1/CAV2) genomic regions, which code for proteins involved in setting vascular tone, are associated with POAG.
Patterns of Exposure of Iberian Wolves (Canis lupus) to Canine Viruses in Human-Dominated Landscapes.
New
Esperón et al., Santiago, Chile. In Ecohealth, Dec 2015
With the aim of gaining knowledge in the dynamics of viral infections in Iberian wolves (Canis lupus) living in anthropized landscapes of northern Spain, we analysed between 2010 and 2013 the samples of 54 wolves by serology and polymerase chain reaction (PCR) for exposure to four pathogenic canine viruses: canine distemper virus (CDV), canine parvovirus-2 (CPV), canine adenovirus 1 and 2 (CAV-1 and CAV-2) and canine herpesvirus.
Bone marrow-derived macrophages exclusively expressed caveolin-2: The role of inflammatory activators and hypoxia.
New
Pekarova et al., Brno, Czech Republic. In Immunobiology, Nov 2015
BMDMs were also transfected with siRNA against caveolin-2.
Enhanced caveolin-1 expression in smooth muscle cells: Possible prelude to neointima formation.
New
Mathew et al., Valhalla, United States. In World J Cardiol, Nov 2015
The expression of caveolin-1 and its regulatory protein peroxisome proliferator-activated receptor (PPAR) γ, caveolin-2, proliferative and anti-apoptotic factors (PY-STAT3, p-Erk, Bcl-xL), endothelial nitric oxide synthase (eNOS) and heat shock protein (HSP) 90 in the lungs were analyzed, and the results from M + H group were compared with the controls, M and H groups.
Modulation of 17β-Estradiol Signaling on Cellular Proliferation by Caveolin-2.
New
Acconcia et al., Roma, Italy. In J Cell Physiol, Nov 2015
Caveolae are ω-shaped membrane sub-domains that are composed of scaffold proteins named caveolins (i.e., caveolin-1, caveolin-2, and caveolin-3).
A Mediterranean diet supplemented with extra virgin olive oil or nuts improves endothelial markers involved in blood pressure control in hypertensive women.
New
Moreno et al., Barcelona, Spain. In Eur J Nutr, Nov 2015
We also observed changes in eNOS, caveolin 2 and ET-1 receptors gene expression which are related to NO metabolites levels and BP.
CAV-2-why a canine virus is a neurobiologist's best friend.
Review
New
Kremer et al., Montpellier, France. In Curr Opin Pharmacol, Oct 2015
Canine adenovirus type 2 (CAV-2) vectors are powerful tools for fundamental and applied neurobiology due to their negligible immunogenicity, preferential transduction of neurons, widespread distribution via axonal transport, and duration of expression in the mammalian brain.
Transcriptional Response of Human Neurospheres to Helper-Dependent CAV-2 Vectors Involves the Modulation of DNA Damage Response, Microtubule and Centromere Gene Groups.
Saggio et al., Roma, Italy. In Plos One, 2014
Helper-dependent (HD) canine adenovirus type 2 vectors (CAV-2) are well suited for this goal.
Recovery rate of multiple enteric viruses artificially seeded in water and concentrated by adsorption-elution with negatively charged membranes: interaction and interference between different virus species.
Spilki et al., Novo Hamburgo, Brazil. In Water Sci Technol, 2014
In order to provide an adequate assessment of its recovery efficiency, this study was conducted to assess viral recovery rates for viral species commonly found in water (HAdV-5, EV, RV, BAdV and CAV-2), quantifying viral genomes at the end of the five different steps of the process.
Deformation of the Outer Hair Cells and the Accumulation of Caveolin-2 in Connexin 26 Deficient Mice.
Kamiya et al., Tokyo, Japan. In Plos One, 2014
Protein analysis revealed an increased protein level of caveolin-2 (CAV2) in Cx26f/fP0Cre mouse cochlea.
Genetics of primary open angle glaucoma.
Review
Araie et al., Tokyo, Japan. In Jpn J Ophthalmol, 2014
Several association studies have been conducted for candidate genes, and genome-wide association studies recently identified new susceptibility loci for POAG, namely, S1 RNA binding domain 1 region on chromosome 2p21, the caveolin 1 and caveolin 2 regions on 7q31, transmembrane and coiled-coil domain 1 region on 1q24, cyclin-dependent kinase inhibitor 2B antisense RNA on 9p21, the SIX1 and SIX6 regions on 14q24 and, possibly, the regulatory region of 8q22.
Loss of bladder smooth muscle caveolae in the aging bladder.
GeneRIF
Sullivan et al., Boston, United States. In Neurourol Urodyn, 2012
caveolin-2 protein expression and immunoreactivity were reduced in bladder smooth muscle at 6 and 12 months of age compared with young animals.
Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma in Caucasians from the USA.
GeneRIF
GENEVA Consortium et al., Boston, United States. In Hum Mol Genet, 2012
The identified single nucleotide polymorphisms are associated with primary open-angle glaucoma in the Caucasian US population and that specific haplotypes located in the CAV1/CAV2 intergenic region are associated with the disease.
Expression of caveolin-1, caveolin-2 and caveolin-3 in thyroid cancer and stroma.
GeneRIF
Koo et al., Seoul, South Korea. In Pathobiology, 2011
Stromal caveolin-2 expression were more frequent in anaplastic carcinoma and diffuse sclerosing variant of papillary carcinoma compared to conventional papillary thyroid carcinoma.
Regulation of Cell Signaling and Function by Endothelial Caveolins: Implications in Disease.
Sowa, Columbia, United States. In Transl Med (sunnyvale), 2011
In addition to overwhelming evidence for the role of endothelial caveolin-1, more recent studies also suggest that endothelial caveolin-2 could possibly play a role in pulmonary disease.
Role of Caveolin Proteins in Sepsis.
Sowa, Columbia, United States. In Pediatr Ther, 2011
Moreover, the most recent report implies that in addition to extensively studied caveolin-1, caveolin-2 is also important in regulating LPS-induced sepsis and might possibly play an opposite role to caveolin-1 in regulating certain pro-inflammatory signaling pathways.
Caveolin-2 is a negative regulator of anti-proliferative function and signaling of transforming growth factor-β in endothelial cells.
GeneRIF
Sowa et al., Columbia, United States. In Am J Physiol Cell Physiol, 2011
The negative regulation of transforming growth factor-beta1 signaling and function by caveolin 2 is independent of caveolin 1 expression levels and is not because of changing targeting of caveolin 1 protein to plasma membrane lipid raft/caveolar domains.
Caveolin-2-deficient mice show increased sensitivity to endotoxemia.
GeneRIF
Lisanti et al., Philadelphia, United States. In Cell Cycle, 2011
Data show that the balance between caveolin-1 and caveolin-2 is important for iNOS expression and ultimately for sepsis outcome.
A second protein marker of caveolae: caveolin-2.
Review
Fang et al., Beijing, China. In Chin Med Sci J, 2010
Caveolin-2, a protein about 20 kD, is a major component of the inner surface of caveolae, small invaginations of the plasma membrane.
Age and long-term protective immunity in dogs and cats.
Review
Larson et al., Madison, United States. In J Comp Pathol, 2010
Thus, even a single dose of modified live virus (MLV) canine core vaccines (against CDV, cav-2 and cpv-2) or MLV feline core vaccines (against feline parvovirus [FPV], feline calicivirus [FCV] and feline herpesvirus [FHV]), when administered at 16 weeks or older, could provide long-term immunity in a very high percentage of animals, while also increasing herd immunity.
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