gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Carbonic anhydrase VB, mitochondrial

CAVB, Car5b
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VB is localized in the mitochondria and shows the highest sequence similarity to the other mitochondrial CA, CA VA. It has a wider tissue distribution than CA VA, which is restricted to the liver. The differences in tissue distribution suggest that the two mitochondrial carbonic anhydrases evolved to assume different physiologic roles. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, OUT, POLYMERASE, HAD, AGE
Papers on CAVB
Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies.
Supuran et al., Calgary, Canada. In J Enzyme Inhib Med Chem, 2014
µM) for the remaining cytosolic (CA III, VII and XIII), membrane-associated/transmembrane (CA IV, IX, XII and XIV), mitochondrial (CA VA and CA VB) and secreted (CA VI) isoforms.
Serendipitous fragment-based drug discovery: ketogenic diet metabolites and statins effectively inhibit several carbonic anhydrases.
Supuran et al., Tampere, Finland. In Chem Commun (camb), 2012
Based on the BHB/statin scaffolds, antiepileptic, antiobesity and antitumor compounds with higher affinity for the various CA isoforms involved in epileptogenesis (CA VA, VB, VII), lipogenesis (CA III, CA VA, CA VB) and tumorigenesis (CA IX and CA XII) may be designed.
Ventricular remodelling is a prerequisite for the induction of dofetilide-induced torsade de pointes arrhythmias in the anaesthetized, complete atrio-ventricular-block dog.
Vos et al., Utrecht, Netherlands. In Europace, 2012
Chronic atrio-ventricular (AV)-block (CAVB) dogs are susceptible to dofetilide-induced TdP.
Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block.
Demolombe et al., Nantes, France. In J Mol Cell Cardiol, 2011
Complete atrioventricular block (CAVB) and related ventricular bradycardia are known to induce ventricular hypertrophy and arrhythmias.
Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
Vos et al., Utrecht, Netherlands. In Circ Arrhythm Electrophysiol, 2011
BACKGROUND: The electrically remodeled canine heart after chronic AV block (CAVB) has a high susceptibility for drug-induced torsade de pointes (TdP) arrhythmias.
Carbonic anhydrases in the mouse harderian gland.
GeneRIF
Parkkila et al., Tampere, Finland. In J Mol Histol, 2010
Car5b and Car13 showed the highest signals in the mouse harderian gland.
Late na(+) current inhibition by ranolazine reduces torsades de pointes in the chronic atrioventricular block dog model.
Vos et al., Utrecht, Netherlands. In J Am Coll Cardiol, 2010
OBJECTIVES: This study investigated whether ranolazine reduces dofetilide-induced torsades de pointes (TdP) in a model of long QT syndrome with down-regulated K(+) currents due to hypertrophic remodeling in the dog with chronic atrioventricular block (cAVB).
Microarray studies on effects of Pneumocystis carinii infection on global gene expression in alveolar macrophages.
Lee et al., Kao-hsiung, Taiwan. In Bmc Microbiol, 2009
The top ten genes up-regulated by Pneumocystis infection were Cxcl10, Spp1, S100A9, Rsad2, S100A8, Nos2, RT1-Bb, Lcn2, RT1-Db1, and Srgn with fold changes ranging between 12.33 and 5.34; and the top ten down-regulated ones were Lgals1, Psat1, Tbc1d23, Gsta1, Car5b, Xrcc5, Pdlim1, Alcam, Cidea, and Pkib with fold changes ranging between -4.24 and -2.25.
The calcium/calmodulin/kinase system and arrhythmogenic afterdepolarizations in bradycardia-related acquired long-QT syndrome.
Nattel et al., Montréal, Canada. In Circ Arrhythm Electrophysiol, 2009
BACKGROUND: Sustained bradycardia is associated with long-QT syndrome in human beings and causes spontaneous torsades de pointes in rabbits with chronic atrioventricular block (CAVB), at least partly by downregulating delayed-rectifier K(+)-current to cause action potential (AP) prolongation.
Biological pacemaker engineered by nonviral gene transfer in a mouse model of complete atrioventricular block.
Charpentier et al., Nantes, France. In Mol Ther, 2008
We hypothesized that a nonviral gene delivery of the hyperpolarization-activated HCN2 channel combined with the beta(2)-adrenergic receptor (ADRB2) would generate a functional pacemaker in a mouse model of complete atrioventricular block (CAVB) induced by radiofrequency ablation of the His bundle.
Sexually dimorphic gene expression in the heart of mice and men.
Review
Noppinger et al., Berlin, Germany. In J Mol Med (berl), 2008
Higher expression levels of X-linked genes were detected in female mice for Xist, Timp1 and Car5b and XIST, EIF2S3X and GPM6B in women.
Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides.
Review
Supuran, Sesto Fiorentino, Italy. In Curr Pharm Des, 2007
Some low nanomolar (or even subnanomolar) inhibitors against such isoforms were recently detected, such as metholazone against CA VII, XII and XIII, chlorthalidone against CA VB, VII, IX, XII and XIII, indapamide against CA VII, IX, XII and XIII, furosemide against CA I, II and XIV, and bumethanide against CA IX and XII.
Carbonic anhydrases as targets for medicinal chemistry.
Review
Scozzafava et al., Sesto Fiorentino, Italy. In Bioorg Med Chem, 2007
Some of them are cytosolic (CA I, CA II, CA III, CA VII, CA XIII), others are membrane-bound (CA IV, CA IX, CA XII, CA XIV and CA XV), CA VA and CA VB are mitochondrial, and CA VI is secreted in saliva and milk.
Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.
GeneRIF
Supuran et al., Sesto Fiorentino, Italy. In Bioorg Med Chem Lett, 2007
activators enhanced kcat, with no effect on KM, favoring the RDS in the catalytic cycle; the activation pattern of the two mitochondrial isoforms is very different from each other and as compared to those of the cytosolic isoforms hCA I and II.
Carbonic anhydrases as drug targets--an overview.
Review
Supuran, Sesto Fiorentino, Italy. In Curr Top Med Chem, 2006
Some of these isozymes are cytosolic (CA I, CA II, CA III, CA VII, CA XIII), others are membrane-bound (CA IV, CA IX, CA XII, CA XIV and CA XV), CA VA and CA VB are mitochondrial, and CA VI is secreted in saliva and milk.
Carbonic anhydrase isozymes in the human pancreas.
Review
Onishi et al., Kōchi, Japan. In Dig Liver Dis, 2001
These isozymes are classified as the CA family with various molecular structures and different subcellular localizations: cytoplasmic CA II, mitochondrial CA VB, secretory CA VI, membrane-bound CA IV, and transmembrane CA IX and XII.
share on facebooktweetadd +1mail to friends