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Calcium channel, voltage-dependent, T type, alpha 1I subunit

Cav3.3, Ca(v)3.3, CACNA1I
This gene encodes the pore-forming alpha subunit of a voltage gated calcium channel. The encoded protein is a member of a subfamily of calcium channels referred to as is a low voltage-activated, T-type, calcium channel. The channel encoded by this protein is characterized by a slower activation and inactivation compared to other T-type calcium channels. This protein may be involved in calcium signaling in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2011] (from NCBI)
Top mentioned proteins: caveolin-3, CACNA1G, V1a, CAN, Cav1.2
Papers on Cav3.3
Cannabinoid receptor agonists modulate calcium channels in rat retinal müller cells.
Wang et al., Shanghai, China. In Neuroscience, Feb 2016
In the present work we show that three subunits of T-type Ca(2+) channels, CaV3.1, CaV3.2 and CaV3.3, as well as one subunit of L-type Ca(2+) channels, CaV1.2, were expressed in rat Müller cells by immunofluorescent staining.
Compensatory reduction of Cav3.1 expression in thalamocortical neurons of juvenile rats of WAG/Rij model of absence epilepsy.
Shuba et al., Kiev, Ukraine. In Epilepsy Res, Jan 2016
was 35% smaller in WAG/Rij strain if compared to the control animals while that of H and I isoforms (Cav3.2 and Cav3.3, respectively) remained stable.
Posttranscriptional regulation of T-type Ca(2+) channel expression by interleukin-6 in prostate cancer cells.
Martin-Caraballo et al., United States. In Cytokine, Dec 2015
Transcripts of the T-type Ca(2+) channel subunit Cav3.2 but not Cav3.1 or Cav3.3 are detected in IL-6 stimulated cells.
Contrasting the roles of the I-II loop gating brake in CaV3.1 and CaV3.3 calcium channels.
Lacinová et al., Bratislava, Slovakia. In Pflugers Arch, Dec 2015
The voltage dependence of current activation is virtually identical in all three CaV3 channels while the current kinetics of the CaV3.3 current is one order slower than that of the CaV3.1 and CaV3.2 channels.
Analgesic effect of a broad-spectrum dihydropyridine inhibitor of voltage-gated calcium channels.
Zamponi et al., Calgary, Canada. In Pflugers Arch, Dec 2015
Additional whole-cell patch clamp experiments in transfected tsA-201 cells revealed that M4 also effectively blocks Cav3.3 (T-type) and Cav2.2 (N-type) currents.
Suppression of Sleep Spindle Rhythmogenesis in Mice with Deletion of CaV3.2 and CaV3.3 T-type Ca2+ Channels.
Astori et al., In Sleep, Dec 2015
The CaV3.3 subtype dominates nRt rhythmic bursting and mediates a substantial fraction of spindle power in the NREM sleep EEG.
Reduced Sleep Spindles in Schizophrenia: A Treatable Endophenotype That Links Risk Genes to Impaired Cognition?
Stickgold et al., Boston, United States. In Biol Psychiatry, Nov 2015
For example, the SZ risk gene CACNA1I encodes a calcium channel that is abundantly expressed in the thalamic spindle generator and plays a critical role in spindle activity based on a mouse knockout.
CaV3.1 T-Type Ca2+ Channels Contribute to Myogenic Signaling in Rat Retinal Arterioles.
Curtis et al., In Invest Ophthalmol Vis Sci, Aug 2015
In contrast, no expression of CaV3.2 or CaV3.3 could be detected in retinal arterioles, although these channels were present on glial cell end-feet surrounding the vessels and retinal ganglion cells, respectively.
[Cognitive Function and Calcium. Cognitive improvement through T type calcium channel stimulation].
Fukunaga, Japan. In Clin Calcium, Feb 2015
Three subtypes of T-type Ca2+ channels Cav3.1 (α1G), Cav3.2 (α1H), Cav3.3 (α1I) encoding by CACNA1G, CACNA1H, CACNA1I genes have been cloned.
Ca-α1T, a fly T-type Ca(2+) channel, negatively modulates sleep.
Jones et al., Taejŏn, South Korea. In Sci Rep, 2014
Voltage-clamp analysis revealed the biophysical properties of Ca-α1T show mixed similarity, sometimes falling closer to Cav3.1, sometimes to Cav3.2, and sometimes to Cav3.3.
Inhibition of T-type Ca2+ Channels by Hydrogen Sulfide.
Peers et al., Leeds, United Kingdom. In Adv Exp Med Biol, 2014
Using patch-clamp electrophysiology, we demonstrate that the H(2)S donor, NaHS, selectively inhibits Cav3.2 T-type Ca(2+) channels heterologously expressed in HEK293 cells, whilst Cav3.1 and Cav3.3 channels were unaffected.
Z944, a Novel Selective T-Type Calcium Channel Antagonist Delays the Progression of Seizures in the Amygdala Kindling Model.
Powell et al., Melbourne, Australia. In Plos One, 2014
At the completion of drug treatment, CaV3.1, CaV3.2 and CaV3.3 mRNA expression levels were assessed in the hippocampus and amygdala using qPCR.
Modulation of T-type calcium channels by bioactive lipids.
Lory et al., Montpellier, France. In Pflugers Arch, 2014
Regulation of these channels appears complex, and several studies have indicated that CaV3.1, CaV3.2, and CaV3.3 currents are directly inhibited by multiple endogenous lipids independently of membrane receptors or intracellular pathways.
Models of calcium permeation through T-type channels.
Shuba, Ukraine. In Pflugers Arch, 2014
The subfamily of LVA channels includes three members, Cav3.1, Cav3.2 and Cav3.3.
T-type calcium channels: functional regulation and implication in pain signaling.
Kawabata et al., Japan. In J Pharmacol Sci, 2012
Cav3.2, and Cav3.3), are now considered to play pivotal roles in processing of pain signals.
Differential interactions of Na+ channel toxins with T-type Ca2+ channels.
Leblanc et al., Baltimore, United States. In J Gen Physiol, 2008
The sodium channel toxins tetrodotoxin and saxitoxin interact with the alpha-subunit of T-type Ca 2+ channels.
Selective inhibition of Cav3.3 T-type calcium channels by Galphaq/11-coupled muscarinic acetylcholine receptors.
Snutch et al., Vancouver, Canada. In J Biol Chem, 2007
two distinct regions of the Cav3.3 channel are necessary and sufficient for complete M1 receptor-mediated channel inhibition
Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity.
Gopalakrishnan et al., United States. In J Biol Chem, 2006
CatSper1 and CatSper2 can associate with and modulate the function of the Ca(v)3.3 channel, which might be important in the regulation of sperm function.
Functional impact of alternative splicing of human T-type Cav3.3 calcium channels.
Perez-Reyes et al., Charlottesville, United States. In J Neurophysiol, 2004
intracellular regions after repeats I and IV play a role in gating interdependently, suggesting a direct interaction, and splice variation of Cav3.3 channels provides a mechanism for fine-tuning latency and duration of low-threshold spikes.
Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.
Lory et al., Montpellier, France. In J Physiol, 2002
Specific contribution of human T-type calcium channel isotypes (alpha(1G), alpha(1H) and alpha(1I)) to neuronal excitability.
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