Inhibition of T-type Ca2+ Channels by Hydrogen Sulfide.
Leeds, United Kingdom. In Adv Exp Med Biol, 2014
Using patch-clamp electrophysiology, we demonstrate that the H(2)S donor, NaHS, selectively inhibits Cav3.2 T-type Ca(2+) channels heterologously expressed in HEK293 cells, whilst Cav3.1 and Cav3.3 channels were unaffected.
Modulation of T-type calcium channels by bioactive lipids.
Montpellier, France. In Pflugers Arch, 2014
Regulation of these channels appears complex, and several studies have indicated that CaV3.1, CaV3.2, and CaV3.3 currents are directly inhibited by multiple endogenous lipids independently of membrane receptors or intracellular pathways.