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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cathepsin S

Cathepsins
The protein encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that may participate in the degradation of antigenic proteins to peptides for presentation on MHC class II molecules. The encoded protein can function as an elastase over a broad pH range in alveolar macrophages. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: CAN, MHC, ACID, HAD, V1a
Papers on Cathepsins
Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-κB.
New
Platt et al., In Biol Chem, Feb 2016
UNASSIGNED: Cathepsins K and V are powerful elastases elevated in endothelial cells by tumor necrosis factor-α (TNFα) stimulation and disturbed blood flow both of which contribute to inflammation-mediated arterial remodeling.
Expression profile analysis of two cathepsin S in channel catfish (Ictalurus punctatus) mucosal tissues following bacterial challenge.
New
Li et al., Qingdao, China. In Fish Shellfish Immunol, Jan 2016
In the present study, two Cathepsin S genes (ctss and ctssa) were captured in channel catfish.
A cystatin F homologue from large yellow croaker (Larimichthys crocea) inhibits activity of multiple cysteine proteinases and Ii chain processing in vitro.
New
Mu et al., Xiamen, China. In Fish Shellfish Immunol, Jan 2016
Moreover, rLycCysF could inhibit the Ii chain processing by recombinant cathepsin S in vitro.
Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.
New
Yang et al., Beijing, China. In Circ Res, Jan 2016
METHODS AND RESULTS: Conditional gene knockout strategy combined with histology and expression analysis showed that Smad4 or TGF-β receptor type II deficiency in SMCs led to the occurrence of aortic aneurysms along with an upregulation of Cathepsin S and Matrix metallopeptidase 12 (MMP12), which are proteases essential for elastin degradation.
Prognostic and predictive biomarkers of AAA growth rate.
New
Lindeman et al., Indianapolis, United States. In Curr Med Res Opin, Jan 2016
Approximately 200 biomarkers were evaluated in a candidate approach that included markers of matrix turnover and cathepsin S activity and a broad-based approach of predominantly inflammation-related and clinical biomarkers.
Endothelial cells and cathepsins: Biochemical and biomechanical regulation.
Review
New
Shockey et al., Atlanta, United States. In Biochimie, Nov 2015
UNASSIGNED: Cathepsins are mechanosensitive proteases that are regulated not only by biochemical factors, but are also responsive to biomechanical forces in the cardiovascular system that regulate their expression and activity to participate in cardiovascular tissue remodeling.
Cathepsins of lepidopteran insects: Aspects and prospects.
Review
New
Giri et al., Pune, India. In Insect Biochem Mol Biol, Sep 2015
Among the various proteases, cathepsins are the most crucial cellular proteases, which play vital roles during insect development.
Cathepsin S: therapeutic, diagnostic, and prognostic potential.
Review
New
Burden et al., In Biol Chem, Aug 2015
Cathepsin S is a member of the cysteine cathepsin protease family.
Recent advances in the field of anti-cancer immunotherapy.
Review
New
Kwok et al., Aomen, Macao. In Bba Clin, Jun 2015
We demonstrate three exciting targets for immunotherapy, TNF-α Converting Enzyme (TACE), Cathepsin S and Urokinase Plasmogen Activator and go over the advances made with one of the most used monoclonal antibodies in cancer therapy, Rituximab; as well as Herceptin, which is used for breast cancer therapy.
Analysis of tumour- and stroma-supplied proteolytic networks reveals a brain-metastasis-promoting role for cathepsin S.
Impact
Joyce et al., New York City, United States. In Nat Cell Biol, 2014
We identified a number of potential modulators of site-specific metastasis, including cathepsin S as a regulator of breast-to-brain metastasis.
Cathepsins: a new culprit behind abdominal aortic aneurysm.
Review
Qin et al., Beijing, China. In Regen Med Res, 2013
Recent studies have reported that lysosomal cathepsins could induce vascular remodeling and AAA formation by regulating vascular inflammation, medial smooth muscle cell apoptosis, neovascularization, and protease expression.
Hepatitis C virus-mediated inhibition of cathepsin S increases invariant-chain expression on hepatocyte surface.
GeneRIF
Ray et al., Saint Louis, United States. In J Virol, 2012
HCV has an inhibitory role on cathepsin S-mediated major histocompatibility complex (MHC) class II maturation, which may contribute to weak immunogenicity of viral antigens in chronic infections.
Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation.
GeneRIF
Platt et al., Atlanta, United States. In J Biol Chem, 2012
Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation.
Cysteine cathepsin S processes leptin, inactivating its biological activity.
GeneRIF
Carmona et al., São Paulo, Brazil. In J Endocrinol, 2012
Cysteine cathepsins may be putative leptin activity regulators in white adipose tissue.
Cathepsin S dominates autoantigen processing in human thymic dendritic cells.
GeneRIF
Tolosa et al., Tübingen, Germany. In J Autoimmun, 2012
Cathepsin S therefore appears to be an important factor that influences selection of autoreactive T cells.
Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation.
GeneRIF
Du et al., Beijing, China. In Plos One, 2011
Cathepsin S deficiency results in abnormal accumulation of autophagosomes in macrophages and enhances Ang II-induced cardiac inflammation.
Association between serum cathepsin S and mortality in older adults.
Impact
GeneRIF
Ärnlöv et al., Uppsala, Sweden. In Jama, 2011
Among elderly individuals in 2 independent cohorts, higher serum cathepsin S levels were associated with increased mortality risk
IL-6-STAT3 controls intracellular MHC class II alphabeta dimer level through cathepsin S activity in dendritic cells.
Impact
GeneRIF
Hirano et al., Yokohama, Japan. In Immunity, 2005
interleukin-6-signal transducer and activator of transcription 3 -mediated increase of cathepsin S activity
Important role of cathepsin S in generating peptides for TAP-independent MHC class I crosspresentation in vivo.
Impact
Rock et al., Worcester, United States. In Immunity, 2004
Dendritic cells lacking the cysteine protease cathepsin S lack the TAP-independent pathway.
Asparagine endopeptidase can initiate the removal of the MHC class II invariant chain chaperone.
Impact
Watts et al., Dundee, United Kingdom. In Immunity, 2003
Cathepsins S or L are known to be required for the final stages of Ii removal in different APCs, but the enzymes which initiate Ii processing have not been identified.
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