Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm.
Beijing, China. In Circ Res, Jan 2016
METHODS AND RESULTS: Conditional gene knockout strategy combined with histology and expression analysis showed that Smad4 or TGF-β receptor type II deficiency in SMCs led to the occurrence of aortic aneurysms along with an upregulation of Cathepsin S and Matrix metallopeptidase 12 (MMP12), which are proteases essential for elastin degradation.
Prognostic and predictive biomarkers of AAA growth rate.
Indianapolis, United States. In Curr Med Res Opin, Jan 2016
Approximately 200 biomarkers were evaluated in a candidate approach that included markers of matrix turnover and cathepsin S activity and a broad-based approach of predominantly inflammation-related and clinical biomarkers.
Endothelial cells and cathepsins: Biochemical and biomechanical regulation.
Atlanta, United States. In Biochimie, Nov 2015
UNASSIGNED: Cathepsins are mechanosensitive proteases that are regulated not only by biochemical factors, but are also responsive to biomechanical forces in the cardiovascular system that regulate their expression and activity to participate in cardiovascular tissue remodeling.
Recent advances in the field of anti-cancer immunotherapy.
Aomen, Macao. In Bba Clin, Jun 2015
We demonstrate three exciting targets for immunotherapy, TNF-α Converting Enzyme (TACE), Cathepsin S and Urokinase Plasmogen Activator and go over the advances made with one of the most used monoclonal antibodies in cancer therapy, Rituximab; as well as Herceptin, which is used for breast cancer therapy.
Cathepsins: a new culprit behind abdominal aortic aneurysm.
Beijing, China. In Regen Med Res, 2013
Recent studies have reported that lysosomal cathepsins could induce vascular remodeling and AAA formation by regulating vascular inflammation, medial smooth muscle cell apoptosis, neovascularization, and protease expression.