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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Cathepsin K

cathepsin K, cathepsin X
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, NFATC, HAD, CAN, V1a
Papers using cathepsin K antibodies
Maintenance of mitochondrial DNA copy number is essential for osteoclast survival
Supplier
Tanaka Sakae et al., In Arthritis Research & Therapy, 2011
... mice with cathepsin K-Cre transgenic mice, in which the ...
Glycosaminoglycan-mediated loss of cathepsin K collagenolytic activity in MPS I contributes to osteoclast and growth plate abnormalities.
Supplier
Jones Malcolm, In PLoS Neglected Tropical Diseases, 2008
... Cathepsin K inhibitor II was purchased from BD Biosciences (Sydney, Australia) ...
Regulation of collagenase activities of human cathepsins by glycosaminoglycans
Supplier
Klingler Anton et al., In Arthritis Research & Therapy, 2003
An enzyme immunoassay for cathepsin K developed by Biomedica Austria (Vienna, Austria) was ...
Papers on cathepsin K
Biomechanical and biochemical regulation of cathepsin K expression in endothelial cells converge at AP-1 and NF-κB.
New
Platt et al., In Biol Chem, Feb 2016
TNFα upregulated cathepsin K via JNK/c-jun activation, but vasoprotective shear stress inhibited TNFα-stimulated cathepsin K expression.
Eriodictyol Inhibits RANKL-Induced Osteoclast Formation and Function via Inhibition of NFATc1 Activity.
New
Xu et al., Nanning, China. In J Cell Physiol, Feb 2016
Eriodictyol also strongly inhibited RANKL-induction of c-Fos levels (a critical component of AP-1 transcription factor required by osteoclasts) and subsequent activation of NFATc1, concomitant with reduced expression of osteoclast specific genes including cathepsin K (Ctsk), V-ATPase-d2 subunit, and tartrate resistant acid phosphatase (TRAcP/Acp5).
The silencing of cathepsin K used in gene therapy for periodontal disease reveals the role of cathepsin K in chronic infection and inflammation.
New
Li et al., Birmingham, United States. In J Periodontal Res, Feb 2016
In this study, we utilized adeno-associated virus (AAV) expressing cathepsin K (Ctsk) small hairpin (sh)RNA (AAV-sh-Ctsk) to silence Ctsk in vivo and subsequently evaluated its impact in periodontitis as a potential therapeutic strategy for this disease.
[Newly developed drugs to improve bone strength].
Review
New
Hagino, Tottori, Japan. In Clin Calcium, Dec 2015
In addition, new drugs with new action mechanisms such as cathepsin K inhibitor or anti-sclerostin antibody are also being developed and it has been reported that they have good potential to increase bone mineral density.
Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis.
New
Lips et al., Gießen, Germany. In Arthritis Res Ther, Dec 2015
Moreover, in M3R(-/-) mice, gene expression of markers for bone degradation (matrix metalloproteinase 13, cathepsin K and receptor activator of nuclear factor-κB ligand) was already increased in mice with low arthritis score.
Alveolar Soft Part Sarcoma.
Review
New
Kirby et al., Iowa City, United States. In Arch Pathol Lab Med, Nov 2015
Cathepsin K is a relatively recent immunohistochemical stain that can aid in the diagnosis.
The role of CTSK in oral and maxillofacial disorders.
Review
New
Xue et al., Xi'an, China. In Oral Dis, Nov 2015
UNASSIGNED: Cathepsin K (CTSK) was thought to be a collagenase, specifically expressed by osteoclasts and played an important role in bone resorption.
Emerging Therapies for Osteoporosis.
Review
New
McClung, Portland, United States. In Endocrinol Metab (seoul), Oct 2015
Inhibiting cathepsin K reduces bone resorption without decreasing the numbers of activities of osteoclasts, thereby preserving or promoting osteoblast function.
Bone antiresorptive agents in the treatment of bone metastases associated with solid tumours or multiple myeloma.
Review
Clézardin et al., Athens, Greece. In Bonekey Rep, 2014
Inhibitors of cathepsin K, Src and activin A are under clinical investigation as potential anti-osteolytics.
Effect of odanacatib on root resorption and alveolar bone metabolism during orthodontic tooth movement.
Bai et al., Beijing, China. In Genet Mol Res, 2014
The expression of cathepsin K was decreased significantly in the 60 g-ODN group.
PDGF-BB secreted by preosteoclasts induces angiogenesis during coupling with osteogenesis.
Impact
Cao et al., Baltimore, United States. In Nat Med, 2014
Treatment with exogenous PDGF-BB or inhibition of cathepsin K to increase the number of preosteoclasts, and thus the endogenous levels of PDGF-BB, increases CD31(hi)Emcn(hi) vessel number and stimulates bone formation in OVX mice.
Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling.
Impact
Neel et al., Providence, United States. In Nature, 2013
Here we use a conditional knockout (floxed) Ptpn11 allele (Ptpn11(fl)) and Cre recombinase transgenic mice to delete Ptpn11 specifically in monocytes, macrophages and osteoclasts (lysozyme M-Cre; LysMCre) or in cathepsin K (Ctsk)-expressing cells, previously thought to be osteoclasts.
Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation.
GeneRIF
Platt et al., Atlanta, United States. In J Biol Chem, 2012
Cathepsin S cannibalism of cathepsin K as a mechanism to reduce type I collagen degradation.
Tumor necrosis factor alpha stimulates cathepsin K and V activity via juxtacrine monocyte-endothelial cell signaling and JNK activation.
GeneRIF
Platt et al., Atlanta, United States. In Mol Cell Biochem, 2012
inflammatory cues and monocyte-endothelial cell interactions upregulate cathepsin K and V activity via a JNK signaling axis
Cathepsin K preferentially solubilizes matured bone matrix.
GeneRIF
Garnero et al., Lyon, France. In Calcif Tissue Int, 2012
the collagenolytic activity of cathepsin K may be increased toward more matured bone collagen.
Clusterin is a specific stabilizer and liberator of extracellular cathepsin K.
GeneRIF
Baici et al., Ljubljana, Slovenia. In Febs Lett, 2012
Data suggest that clusterin increases stability of cathepsin K in dilute/concentrated solutions; clusterin prevents substrate inhibition of cathepsin K; kinetic measurements show that clusterin binds cathepsin K with high affinity.
Osteoporosis: now and the future.
Review
Impact
Hofbauer et al., Dresden, Germany. In Lancet, 2011
The most promising novel treatments include: denosumab, a monoclonal antibody for receptor activator of NF-κB ligand, a key osteoclast cytokine; odanacatib, a specific inhibitor of the osteoclast protease cathepsin K; and antibodies against the proteins sclerostin and dickkopf-1, two endogenous inhibitors of bone formation.
Constitutive expression of cathepsin K in the human intervertebral disc: new insight into disc extracellular matrix remodeling via cathepsin K and receptor activator of nuclear factor-κB ligand.
GeneRIF
Hanley et al., Charlotte, United States. In Arthritis Res Ther, 2010
Cathepsin K gene expression was found to be significantly greater in more degenerated compared to healthier discs
Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.
Impact
Takayanagi et al., Tokyo, Japan. In Science, 2008
Cathepsin K was originally identified as an osteoclast-specific lysosomal protease, the inhibitor of which has been considered might have therapeutic potential.
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells.
Impact
Lapidot et al., Israel. In Nat Med, 2006
Finally, the major bone-resorbing proteinase, cathepsin K, also cleaved SDF-1 and SCF.
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