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Cathepsin H

cathepsin H, CTSH
The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. [provided by RefSeq, Mar 2010] (from NCBI)
Top mentioned proteins: Cathepsins, ACID, HAD, CAN, aminopeptidase
Papers on cathepsin H
Polymorphisms in the CTSH gene may influence the progression of diabetic retinopathy: a candidate-gene study in the Danish Cohort of Pediatric Diabetes 1987 (DCPD1987).
Brorsson et al., Copenhagen, Denmark. In Graefes Arch Clin Exp Ophthalmol, Nov 2015
RESULTS: We found the CTSH/rs3825932 variant (C > T) was associated with reduced risk of progression to proliferative diabetic retinopathy (PDR) (OR [95 % CI] = 0.20 [0.07-0.56],
Functional relevance for type 1 diabetes mellitus-associated genetic variants by using integrative analyses.
Lei et al., Suzhou, China. In Hum Immunol, Oct 2015
Of the 9 eQTL genes, 6 (TAP2, HLA-DOB, HLA-DQB1, HLA-DQA1, HLA-DRB5 and CTSH) were differentially expressed in type 1 DM-associated related cells.
Chalcones, semicarbazones and pyrazolines as inhibitors of cathepsins B, H and L.
Kaur et al., India. In Int J Biol Macromol, Sep 2015
cathepsin H [EC] and cathepsin L [EC] are the most versatile lysosomal cysteine proteases and are responsible for intracellular protein degradation.
Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease.
Mach et al., Vienna, Austria. In Biochimie, Aug 2015
For this reason, we have now characterized two major N. benthamiana PLCPs in detail: aleurain-like protease (NbALP) and cathepsin B (NbCathB).
Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases.
Wallace et al., Cambridge, United Kingdom. In Hum Mol Genet, Jul 2015
Previously published candidate causal genes were over-represented amongst genes exhibiting colocalisation (odds ratio > 1.5), and we identified evidence for colocalisation (posterior odds > 5) between cis eQTLs in at least one cell type and at least one disease for six genes: ADAM15, RGS1, CARD9, LTBR, CTSH and SYNGR1.
2,3-Dihydroquinazolin-4(1H)-one derivatives as potential non-peptidyl inhibitors of cathepsins B and H.
Raghav et al., India. In Bioorg Chem, Apr 2015
In the present work we report the synthesis of some 2,3-dihydroquinazolin-4(1H)-ones followed by their evaluation as cysteine protease inhibitors in general and cathepsin B and cathepsin H inhibitors in particular.
Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing.
Zhang et al., Guangzhou, China. In Invest Ophthalmol Vis Sci, 2015
PURPOSE: To evaluate variants in the LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 genes in 298 unrelated patients with early-onset high myopia (eoHM).
N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H.
Garg et al., India. In Bioorg Chem, 2014
After a preliminary screening of the compounds as inhibitors to cysteine proteases in general, studies were carried out to study their inhibitory effects on cathepsin B and cathepsin H. SAR studies show that N-formylpyrazolines were better inhibitors than N-benzoylpyrazolines.
Comparative genomic of the teleost cathepsin B and H and involvement in bacterial induced immunity of miiuy croaker.
Xu et al., Zhoushan, China. In Fish Shellfish Immunol, 2014
In addition, the gene synteny analysis showed that miiuy croaker cathepsin B has a closer relationship to stickleback and fugu than to cave fish and zebrafish, and cathepsin H was most similar with the 2 subtype in tilapia and fugu.
The induction of neuronal death by up-regulated microglial cathepsin H in LPS-induced neuroinflammation.
Ma et al., Dalian, China. In J Neuroinflammation, 2014
However, cathepsin H (Cat H), a cysteine protease, has been far less studied in neuroinflammation, compared to cathepsins B, D, L, and S. The expression patterns and functional roles of Cat H in the brain in neuroinflammation remain unknown.
The autoimmune basis of narcolepsy.
Mignot et al., Palo Alto, United States. In Curr Opin Neurobiol, 2013
Genome-wide association studies have strengthened the association between narcolepsy and immune system gene polymorphisms, including the identification of polymorphisms in the T cell receptor alpha locus, TNFSF4 (also called OX40L), Cathepsin H (CTSH) the purinergic receptor P2RY11, and the DNA methyltransferase DNMT1.
Genetic association, seasonal infections and autoimmune basis of narcolepsy.
Mignot et al., Palo Alto, United States. In J Autoimmun, 2013
Genome-wide association analysis shows a strong association between narcolepsy and polymorphisms in the TCRα locus and weaker associations within TNFSF4 (also called OX40L), Cathepsin H and the P2RY11-DNMT1 (purinergic receptor subtype P2Y11 to DNMT1, a DNA methytransferase) loci, suggesting an autoimmune basis.
Cathepsin H regulated by the thyroid hormone receptors associate with tumor invasion in human hepatoma cells.
Lin et al., Taiwan. In Oncogene, 2011
CTSH overexpression in a subset hepatoma may be thyroid hormone receptor dependent and suggests that this overexpression has an important role in hepatoma progression.
Cathepsins are involved in virus-induced cell death in ICP4 and Us3 deletion mutant herpes simplex virus type 1-infected monocytic cells.
Hukkanen et al., Turku, Finland. In J Gen Virol, 2011
These data indicate that cathepsins B, L and S may act as cell-death mediators in in monocytic cells infected with ICP4 and Us3 deletion mutant herpes simplex virus type 1.
The interactomics of sortilin: an ancient lysosomal receptor evolving new functions.
Morales et al., Montréal, Canada. In Histol Histopathol, 2009
We have demonstrated that the transport of cathepsin D is partially dependent upon sortilin, that cathepsin H requires sortilin, and that cathepsins K and L attain the lysosomes in a sortilin-independent fashion.
Levels of cathepsins S and H in pleural fluids of inflammatory and neoplastic origin.
Kos et al., Plzeň, Czech Republic. In Int J Biol Markers, 2009
In contrast to cathepsin S, cathepsin H values did not correlate with markers of inflammation, indicating a specific role for cathepsin H in the pleural host response.
Cathepsin B, cathepsin H, cathepsin X and cystatin C in sera of patients with early-stage and inflammatory breast cancer.
Kos et al., Leuven, Belgium. In Int J Biol Markers, 2008
cathepsin B, cathepsin H, cathepsin X and cystatin C may have roles in inflammatory breast cancer
Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis.
Griese et al., München, Germany. In Eur Respir J, 2008
A general defect in napsin A or cathepsin H expression or activity was not the specific cause for abnormal surfactant accumulation in juvenile pulmonary alveolar proteinosis
[Thyroid crisis and protein C deficiency in a case of superior sagittal sinus thrombosis].
Akikusa et al., Matsudo, Japan. In Brain Nerve, 2007
Day 12, laboratory examinations revealed an undetectable TSH-level CTSH (thyroid stimulating hormone) <0.005 mcIU/ml), with a level of free thyroxin 7.77 ng/dl (0.9-1.7), free triiodothyronin 29.6 pg/ml (2.3-4.3), and positive anti-TSH receptor antibodies determined subsequently.
Expression microarray analysis of brain tumors: what have we learned so far.
Moreno et al., Atlanta, United States. In Front Biosci, 2002
These genes include EGFR, VEGF, transcription factor AP-2, insulin growth factor binding proteins 3 and 5, matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases, CD44, basic fibroblast growth factor, and cathepsin H. Finally, novel roles for a few genes, including insulin growth factor binding protein 2 and apolipoprotein D, have been revealed for the first time by expression microarrays.
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