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Cathepsin D

cathepsin D
This gene encodes a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. This proteinase, which is a member of the peptidase C1 family, has a specificity similar to but narrower than that of pepsin A. Transcription of this gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, Cathepsins, V1a
Papers using cathepsin D antibodies
Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress.
Supplier
Linden Rafael, In PLoS ONE, 2008
... Antibodies against HA, α-tubulin, VDAC2, Oct1, and cathepsin D were purchased from Abcam (Cambridge, MA, UK) ...
Cathepsin D: a cellular roadmap
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Malhotra Vivek et al., In The Journal of Cell Biology, 2007
... monoclonal anti–β-actin were obtained from Sigma-Aldrich, sheep anti–human TGN46 were obtained from AbD Serotec, monoclonal anti–cathepsin D antibody was obtained from Cell Signaling Technology, and anti-Cab45 monoclonal ...
Rab8 is involved in zymogen granule formation in pancreatic acinar AR42J cells
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da Cruz e Silva Odete AB et al., In Molecular Neurodegeneration, 2007
... Bioreagents) and anti-Rab7 (late-endosomal marker) (CytoSignal) polyclonal rabbit antibodies, polyclonal goat clathrin antibody (ICN Immunobiologicals), anti-cathepsin D (lysosomal marker) monoclonal antibody (BD Biosciences), and polyclonal anti-VPS35 C-20 ...
Long-term safety and efficacy of enzyme replacement therapy for Fabry disease
Supplier
Elleder Milan et al., In Virchows Archiv, 2003
... Polyclonal antibody against cathepsin D was purchased from DAKO and used in dilution ...
Pre-and postnatal diagnosis of patients with CLN1 and CLN2 by assay of palmitoyl-protein thioesterase and tripeptidyl-peptidase I activities
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Mikuláštík Josef et al., In Acta Neuropathologica, 2000
... In our review of the archived tissue samples, cathepsin D was detected with rabbit polyclonal antibodies (DAKO, Copenhagen, Denmark; dilution 1:2,000 ...
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Papers on cathepsin D
Unveiling a novel biomarker panel for diagnosis and classification of well-differentiated thyroid carcinomas.
New
Svasti et al., Bangkok, Thailand. In Oncol Rep, Feb 2016
Eight biomarkers could distinguish PTC from normal tissues, namely enolase 1, triose phosphate isomerase, cathepsin D, annexin A2, cofilin 1, proliferating cell nuclear antigen (PCNA), copine 1 and heat shock protein 27 kDa (HSP27).
Analysis of catalytic properties of tripeptidyl peptidase I (TTP-I), a serine carboxyl lysosomal protease, and its detection in tissue extracts using selective FRET peptide substrate.
New
Juliano et al., São Paulo, Brazil. In Peptides, Feb 2016
The selectivity of NH2-RWFFIQ-EDDnp to TPP-I was also demonstrated by the 400 times higher kcat/KM compared to generally used substrate, NH2-AAF-MCA and by its resistance to hydrolysis by cathepsin D that is present in high levels in kidneys.
Tissue Levels of Stefin A and Stefin B in Hepatocellular Carcinoma.
New
Xie et al., Putian, China. In Anat Rec (hoboken), Feb 2016
The immunohistochemical staining of cathepsin B and cathepsin D, and the ratio of cathepsins to stefins were assessed.
Neuroprotection by selective neuronal deletion of Atg7 in neonatal brain injury.
New
Zhu et al., Göteborg, Sweden. In Autophagy, Feb 2016
Moreover, we investigated the lentiform nucleus of human newborns who died after severe perinatal asphyxia and found increased neuronal autophagy after severe hypoxic-ischemic encephalopathy compared to control uninjured brains, as indicated by the numbers of MAP1LC3B/LC3B (microtubule-associated protein 1 light chain 3)-, LAMP1 (lysosomal-associated membrane protein 1)-, and CTSD (cathepsin D)-positive cells.
Glycogen Synthase Kinase-3β and Caspase-2 Mediate Ceramide- and Etoposide-Induced Apoptosis by Regulating the Lysosomal-Mitochondrial Axis.
New
Chen et al., Taipei, Taiwan. In Plos One, Dec 2015
Here, we report the regulation of Mcl-1 destabilization and cathepsin D-regulated caspase-8 activation by GSK-3β and caspase-2.
Cell biology of the NCL proteins: What they do and don't do.
Review
New
Pearce et al., Sioux Falls, United States. In Biochim Biophys Acta, Oct 2015
Some of them such as CLN1 (palmitoyl protein thioesterase 1), CLN2 (tripeptidyl-peptidase 1), CLN5, CLN10 (cathepsin D), and CLN13 (cathepsin F), are lysosomal soluble proteins; others like CLN3, CLN7, and CLN12, have been proposed to be lysosomal transmembrane proteins.
The Role of Retromer in Alzheimer's Disease.
Review
New
Tan et al., Qingdao, China. In Mol Neurobiol, Aug 2015
Retromer dysfunction may result in decreasing the clearance of extracellular tau and the level of cathepsin D, which enables tau-induced neurotoxicity.
New paradigm of an old target: an update on structural biology and current progress in drug design towards plasmepsin II.
Review
New
Bhakat et al., India. In Eur J Med Chem, Jun 2015
But majority of Plm II inhibitors suffered from poor selectivity over cathepsin D as well as other subtypes of plasmepsins.
The Potential Role of the Proteases Cathepsin D and Cathepsin L in the Progression and Metastasis of Epithelial Ovarian Cancer.
Review
Whatmore et al., Exeter, United Kingdom. In Biomolecules, 2014
In this review we examine the role of some of these alternative factors, specifically cathepsin D and cathepsin L.
Breast cancer statistics and markers.
Review
Venkanteshan et al., Guntūr, India. In J Cancer Res Ther, 2014
Here, the review is been focused on different breast cancer markers, that is, tissue markers (hormone receptors, human epidermal growth factor-2, urokinase plasminogen activator, plasminogen activator inhibitor, p53 and cathepsin D), genetic markers (BRAC1 and 2 and gene expression microarray technique, etc.), and serum markers (CA 15.3, BR 27.29, MCA, CA 549, carcinoembryonic antigen, oncoproteins, and cytokeratins) used in present diagnosis, but none of the mentioned markers can diagnose breast cancer at an early stage.
Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis.
Impact
Akira et al., Ōsaka, Japan. In Immunity, 2013
Upon poly IC stimulation, cathepsin D was released into the cytoplasm from the lysosome to interact with IPS-1, an adaptor molecule for RLRs.
Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells.
GeneRIF
Kim et al., Chinju, South Korea. In Cancer Lett, 2012
inhibition of autophagy could be a novel strategy for the adjuvant chemotherapy of CatD-expressing cancers
Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.
GeneRIF
Simon et al., Bern, Switzerland. In J Biol Chem, 2012
cathepsin D is able to initiate the caspase cascade by direct activation of caspase-8.
Expression of cathepsin-D in primary breast cancer and corresponding local recurrence or metastasis: an immunohistochemical study.
GeneRIF
Jeschke et al., München, Germany. In Anticancer Res, 2012
Cathepsin-D was significantly up-regulated in all the study groups compared to controls. No difference was found between primary tumors and their corresponding recurrences or metastases
Cathepsin D and its prognostic value in neuroepithelial brain tumors.
GeneRIF
Masić et al., Varaždin, Croatia. In Coll Antropol, 2012
There is real possibility to use Cath D as an independent prognostic factor in human glioma progression.
c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis.
GeneRIF
Smarda et al., Brno, Czech Republic. In Mol Cancer, 2011
c-Myb regulates matrix metalloproteinases 1/9, and cathepsin D: implications for matrix-dependent breast cancer cell invasion and metastasis.
American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.
Review
Impact
American Society of Clinical Oncology et al., New Haven, United States. In J Clin Oncol, 2007
The following categories demonstrated insufficient evidence to support routine use in clinical practice: DNA/ploidy by flow cytometry, p53, cathepsin D, cyclin E, proteomics, certain multiparameter assays, detection of bone marrow micrometastases, and circulating tumor cells.
A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.
Impact
GeneRIF
Drexler et al., Hannover, Germany. In Cell, 2007
Myocardial STAT3 protein levels are reduced and serum levels of activated cathepsin D and 16 kDa prolactin are elevated in postpartum cardiomyopathy patients.
Molecular events underlying pregnancy-induced cardiomyopathy.
Impact
Leinwand, Boulder, United States. In Cell, 2007
In this issue, Hilfiker-Kleiner et al. (2007) report that a reduction in STAT3 and a concomitant increase in cathepsin D may be a cause of this disease.
Compartmentalization of TNF receptor 1 signaling: internalized TNF receptosomes as death signaling vesicles.
Impact
Schütze et al., Regensburg, Germany. In Immunity, 2004
Furthermore, fusion of TNF receptosomes with trans-Golgi vesicles results in activation of acid sphingomyelinase and cathepsin D. Thus, TNF receptosomes establish the different TNF signaling pathways by compartmentalization of plasma membrane-derived endocytic vesicles harboring the TNF-R1-associated DISC.
More papers using cathepsin D antibodies
Different biosynthetic transport routes to the plasma membrane in BHK and CHO cells
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Rodriguez-Boulan Enrique et al., In The Journal of Cell Biology, 1995
... Matlin (Harvard University, Boston, MA); polyclonal antibody against human cathepsin D (Biodesign Intl., Kennebunkport, ME); mAb ...
Phagosome–lysosome fusion is a calcium-independent event in macrophages
Supplier
Andrews Norma W. et al., In The Journal of Cell Biology, 1995
... Purified rabbit antibodies against cathepsin D were from Biodesign Intl ...
Neuronal ubiquitin and neurofilament expression in different lysosomal storage disorders
Supplier
Elleder Milan et al., In Acta Neuropathologica, 1991
... Cathepsin D (rabbit polyclonal)DAKO, Copenhagen, Denmark ...
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