Pyruvate kinase expression (PKM1 and PKM2) in cancer-associated fibroblasts drives stromal nutrient production and tumor growth
In Cell Cycle, 2010
... #NBP1–00085, Novus; for immunostaining #2026–1, Epitomics), anti-LAMP1 [#sc-17768 (E-5); Santa Cruz Biotech], anti-BNIP-3 (#ab10433; Abcam), anti-Cathepsin B (#sc-13985 (FL-339); Santa Cruz Biotech), anti-OXPHOS (#MS601; Mitosciences), anti-β actin (#A5441, Sigma), ...
Seoul, South Korea. In Acc Chem Res, 2012
The polypeptide copolymers were stable in the phosphate buffered saline, but the presence of proteolytic enzymes such as elastase, cathepsin B, cathepsin C, and matrix metallopreoteinase accelerated their degradation.
Stat3 controls lysosomal-mediated cell death in vivo.
Cambridge, United Kingdom. In Nat Cell Biol, 2011
Furthermore, although cell death through LMP is independent of executioner caspases 3, 6 and 7, it requires Stat3, which upregulates the expression of lysosomal proteases cathepsin B and L, while downregulating their endogenous inhibitor Spi2A (ref.