Safinamide for symptoms of Parkinson's disease.
Berlin, Germany. In Drugs Today (barc), Nov 2015
Safinamide is a novel instrument for the drug therapy of Parkinson's disease with better safety and tolerability particularly concerning diarrhea than inhibitors of catechol-O-methyltransferase, like entacapone, according to an indirect comparison within a meta-analysis with entacapone.
Update on the genetics of the fibromyalgia syndrome.
Tel Aviv-Yafo, Israel. In Best Pract Res Clin Rheumatol, Feb 2015
While many of these have focused in the past on markers related to neurotransmitter systems such as catecholamines (catechol-O-methyltransferase (COMT)) and serotonin, novel target genes have recently emerged.
Analysis of CYP1A1 and COMT polymorphisms in women with cervical cancer.
São Paulo, Brazil. In Genet Mol Res, 2014
The aim of this case-control study was to obtain a comprehensive panel of genetic polymorphisms present only in genes (cytochrome P-450 1A1 - CYP1A1 and catechol-O-methyl transferase - COMT) within the metabolic pathway of sex steroids and determine their possible associations with the presence or absence of cervical cancer.