Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade.more suppliers
In PLoS ONE, 2007
... Antibodies against PARP, Bax, Bak, Bcl-2, Bcl-xl, Bid, p21, caspase 7, caspase-8, caspase-9 and HRP-secondary antibodies were from Cell Signaling Technology (USA) ...
The autoimmune conundrum in common variable immunodeficiency disorders.
Utrecht, Netherlands. In Curr Opin Allergy Clin Immunol, Dec 2015
Thus, cytotoxic T lymphocyte-associated antigen 4 or caspase-9 deficiency presenting with CVID-like phenotypes reiterate concepts of immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome and autoimmune lymphoproliferative syndrome.
Caspase-9 as a therapeutic target for treating cancer.
Seoul, South Korea. In Expert Opin Ther Targets, 2015
INTRODUCTION: Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Improving the safety of cell therapy products by suicide gene transfer.
Birmingham, United States. In Front Pharmacol, 2013
This review presents the suicide gene safety systems reported to date, with a focus on the state-of-the-art and potential applications regarding two of the most extensively validated suicide genes, including the clinical setting: herpes-simplex-thymidine-kinase and inducible-caspase-9.
An alternative splicing network links cell-cycle control to apoptosis.
Boston, United States. In Cell, 2010
The screen identified many regulators of Bcl-x and Mcl1 splicing, notably an extensive network of cell-cycle factors linked to aurora kinase A. Drugs or siRNAs that induce mitotic arrest promote proapoptotic splicing of Bcl-x, Mcl1, and caspase-9 and alter splicing of other apoptotic transcripts.
Three immunomarker support vector machines-based prognostic classifiers for stage IB non-small-cell lung cancer.
Guangzhou, China. In J Clin Oncol, 2009
The SVM2 model integrates age, cancer cell type, and 19 markers, including BCL2, caspase-9, CD34MVD, low-molecular-weight cytokeratin, high-molecular-weight cytokeratin, cyclo-oxygenase-2, EMA, HER2, matrix metalloproteinases (MMP) -2, MMP-9, p16, p21ras, p21WAF1, p27kip1, p53, TIMP-1, TIMP-2, vascular endothelial growth factor (VEGF), and beta-catenin.
The apoptosome: signalling platform of cell death.
More papers using
Los Angeles, United States. In Nat Rev Mol Cell Biol, 2007
The formation of the apoptosome and the activation of its effector, caspase-9, reveals a sophisticated mechanism that might be more common than was initially thought.
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
In PLoS ONE, 2007
... Carlsbad, CA, USA), Z-Val-Ala-DL-Asp (methoxy)-fluoromethylketone (Z-VAD-FMK, BD Biosciences, San Jose, CA, USA), Caspase-3/CPP32, FLICE/caspase-8 and caspase-9 colorimetric assay kit (Biovision, Milpitas, CA, USA), Annexin-V ... Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
In Cell Death & Disease, 1994
... (1:1000, #9662, Cell Signaling Technology, Danvers, MA, USA), anti-Cleaved Caspase-3 (1:250, #9661, Cell Signaling Technology), anti-Caspase-9 (1:500, #9504, Cell Signaling Technology), anti-Cleaved Caspase-9 (1:250, ... Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
In International Journal of Molecular Sciences, 1978
... CA, USA), anti-phospho-Akt kinase (reacts with Ser473-phosphorylated Akt kinase), anti-caspase-3, anti-cleaved caspase-3, anti-caspase-9, and anti-cleaved caspase-9 (all from Cell Signaling Technology Inc., Danvers, MA, ...