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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Caspase 9, apoptosis-related cysteine peptidase

caspase-9
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Top mentioned proteins: PrP, caspase-3, bcl-2, Bax, V1a
Papers using caspase-9 antibodies
The in vitro stability and in vivo pharmacokinetics of curcumin prepared as an aqueous nanoparticulate formulation
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Kumar GS Vinod et al., In International Journal of Nanomedicine, 2009
... Rabbit monoclonal antibody against caspase-3 and rabbit polyclonal antibody against caspase-9 were obtained from Cell Signaling (Beverly, MA) ...
Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach.
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Sarkar Fazlul H., In PLoS ONE, 2008
... The rabbit polyclonal antibody directed against the cleaved caspase-9 fragment was purchased from Cell Signaling Technology (Danvers, MA, U.S.A.) ...
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade.
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Zhivotovsky Boris, In PLoS ONE, 2007
... Antibodies against PARP, Bax, Bak, Bcl-2, Bcl-xl, Bid, p21, caspase 7, caspase-8, caspase-9 and HRP-secondary antibodies were from Cell Signaling Technology (USA) ...
Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway
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Gallyas Ferenc, In PLoS ONE, 2007
... Antibody against caspase-9 was purchased from Epitomics (Burlingame, CA, USA) ...
Analyzing real-time PCR data by the comparative C(T) method.
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Basu Sujit, In PLoS ONE, 2007
... Phospho-H2AX, Phospho-Chk-2, 53 BP1 cleaved caspase-8, caspase-9 and PARP antibodies were from Cell Signaling ...
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Papers on caspase-9
5-Fluorouracil-Induced Apoptosis Changes in Cultured Corneal Epithelial Cells.
New
Hong et al., Kao-hsiung, Taiwan. In J Ocul Pharmacol Ther, Feb 2016
Pretreatment with a general caspase inhibitor (Z-VAD-FMK), a caspase-8 inhibitor (Z-IETD-FMK), and a caspase-9 inhibitor (Z-LEHD-FMK) reversed 5-FU-induced cellular damage.
Neuroprotective Effect of Sulfated Polysaccharide Isolated from Sea Cucumber Stichopus japonicus on 6-OHDA-induced Death in SH-SY5Y through Inhibition of MAPK and NF-κB and Activation of PI3K/Akt Signaling Pathways.
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Ji et al., Weihai, China. In Biochem Biophys Res Commun, Feb 2016
Effect of SJP on 6-OHDA-induced cell death in SH-SY5Y cells is associated with an arrest in the G1/S phase of the cell cycle and inhibits the expression of Cyclin D3. 6-OHDA-induced intracellular generation of ROS and mitochondrial dysfunctions, release of cytochrome c, imbalance of Bax/Bcl-2, cleaved caspase-9/caspase-9 and cleaved caspase-3/caspase-3 ratio, and p-p53 activation were strikingly attenuated by SJP pretreatment.
Ophiopogonin D inhibits cell proliferation, causes cell cycle arrest at G2/M, and induces apoptosis in human breast carcinoma MCF-7 cells.
New
Huang et al., Shanghai, China. In J Integr Med, Jan 2016
Furthermore, activation of caspase-8 and caspase-9 was involved in ophiopogonin D-induced apoptosis.
Functional mechanism of the enhancement of 5-fluorouracil sensitivity by TUSC4 in colon cancer cells.
New
Liu et al., Harbin, China. In Oncol Lett, Dec 2015
Furthermore, 5-FU upregulated caspase-3 and caspase-9, promoting apoptosis in TUSC4-overexpressing cells compared with cells that were transduced with TUSC4 or treated with 5-FU and NC cells.
The critical role of Akt in cardiovascular function.
Review
New
Su et al., Augusta, United States. In Vascul Pharmacol, Nov 2015
Akt promotes cell survival via caspase-9, YAP, Bcl-2, and Bcl-x activities.
Caspase-9 as a therapeutic target for treating cancer.
Review
Kim et al., Seoul, South Korea. In Expert Opin Ther Targets, 2015
INTRODUCTION: Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Apoptotic caspases suppress mtDNA-induced STING-mediated type I IFN production.
Impact
Kile et al., Australia. In Cell, 2015
Pharmacological caspase inhibition or genetic deletion of caspase-9, Apaf-1, or caspase-3/7 causes dying cells to secrete IFN-β.
Bufalin Induces Mitochondria-Dependent Apoptosis in Pancreatic and Oral Cancer Cells by Downregulating hTERT Expression via Activation of the JNK/p38 Pathway.
Jiang et al., Shenyang, China. In Evid Based Complement Alternat Med, 2014
hTERT silencing in CAPAN-2 and CAL-27 cells by siRNA resulted in increased caspase-9/-3 cleavage and DNA damage and decreased cell viability.
Improving the safety of cell therapy products by suicide gene transfer.
Review
Di Stasi et al., Birmingham, United States. In Front Pharmacol, 2013
This review presents the suicide gene safety systems reported to date, with a focus on the state-of-the-art and potential applications regarding two of the most extensively validated suicide genes, including the clinical setting: herpes-simplex-thymidine-kinase and inducible-caspase-9.
The inducible caspase-9 suicide gene system as a "safety switch" to limit on-target, off-tumor toxicities of chimeric antigen receptor T cells.
Review
Brown et al., Adelaide, Australia. In Front Pharmacol, 2013
Immune modulation has become a central element in many cancer treatments, and T cells genetically engineered to express chimeric antigen receptors (CAR) may provide a new approach to cancer immunotherapy.
Neem (Azadirachta indica L.) leaf extract deteriorates oocyte quality by inducing ROS-mediated apoptosis in mammals.
Review
Pandey et al., Benares, India. In Springerplus, 2013
The increased cytosolic cytochrome c level induces caspase-9 and caspase-3 activities that trigger destruction of structural and specific proteins leading to DNA fragmentation and thereby oocyte apoptosis.
An alternative splicing network links cell-cycle control to apoptosis.
Impact
Silver et al., Boston, United States. In Cell, 2010
The screen identified many regulators of Bcl-x and Mcl1 splicing, notably an extensive network of cell-cycle factors linked to aurora kinase A. Drugs or siRNAs that induce mitotic arrest promote proapoptotic splicing of Bcl-x, Mcl1, and caspase-9 and alter splicing of other apoptotic transcripts.
The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex.
Impact
Mehlen et al., Lyon, France. In Nat Cell Biol, 2009
We demonstrate that, in the absence of Shh, Ptc recruits a protein complex that includes DRAL, one of the caspase recruitment (CARD)-domain containing proteins TUCAN (family member, 8) or NALP1 (NLR family, pyrin domain containing 1) and apical caspase-9.
Three immunomarker support vector machines-based prognostic classifiers for stage IB non-small-cell lung cancer.
Impact
Rong et al., Guangzhou, China. In J Clin Oncol, 2009
The SVM2 model integrates age, cancer cell type, and 19 markers, including BCL2, caspase-9, CD34MVD, low-molecular-weight cytokeratin, high-molecular-weight cytokeratin, cyclo-oxygenase-2, EMA, HER2, matrix metalloproteinases (MMP) -2, MMP-9, p16, p21ras, p21WAF1, p27kip1, p53, TIMP-1, TIMP-2, vascular endothelial growth factor (VEGF), and beta-catenin.
Caspase-9 regulates apoptosis/proliferation balance during metamorphic brain remodeling in Xenopus.
GeneRIF
Demeneix et al., Paris, France. In Proc Natl Acad Sci U S A, 2007
XR11 and caspase-9, two key members of the mitochondrial death pathway, are implicated in controlling the proliferative status of neuroblasts in the metamorphosing Xenopus brain.
The apoptosome: signalling platform of cell death.
Review
Impact
Salvesen et al., Los Angeles, United States. In Nat Rev Mol Cell Biol, 2007
The formation of the apoptosome and the activation of its effector, caspase-9, reveals a sophisticated mechanism that might be more common than was initially thought.
Involvement of caspase-9 in execution of the maternal program of apoptosis in Xenopus late blastulae overexpressed with S-adenosylmethionine decarboxylase.
GeneRIF
Shiokawa et al., Tokorozawa, Japan. In Biochem Biophys Res Commun, 2005
results indicate that activation of caspase-9 is a key step for execution of the maternally preset program of apoptosis in Xenopus early embryos
More papers using caspase-9 antibodies
Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells.
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Jin Dong-Yan, In PLoS ONE, 2007
... (Santa Cruz, CA), and antibodies to caspase-9 and TRAIL were from Cell Signaling Technology (Beverly, MA).
Statin-induced inhibition of MCF-7 breast cancer cell proliferation is related to cell cycle arrest and apoptotic and necrotic cell death mediated by an enhanced oxidative stress.
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Gartel Andrei L., In PLoS ONE, 2007
... Carlsbad, CA, USA), Z-Val-Ala-DL-Asp (methoxy)-fluoromethylketone (Z-VAD-FMK, BD Biosciences, San Jose, CA, USA), Caspase-3/CPP32, FLICE/caspase-8 and caspase-9 colorimetric assay kit (Biovision, Milpitas, CA, USA), Annexin-V ...
Nonviral delivery of synthetic siRNAs in vivo
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Buday Laszlo, In PLoS ONE, 2006
... Antibodies for GAPDH, ERK1, phospho-p21 (Thr145), caspase-8 and caspase-9 were from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
Dysequilibrium between caspases and their inhibitors in a mouse model for amyotrophic lateral sclerosis
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Iłżecka Joanna, In Neurological Sciences, 2006
... levels were measured by the enzyme-linked immunosorbent method using the commercial ELISA kit for human Caspase-9 (Bender MedSystems, Austria) in accordance with ...
Low molecular weight fucoidan increases VEGF165-induced endothelial cell migration by enhancing VEGF165 binding to VEGFR-2 and NRP1.
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Lebedeva Irina V., In PLoS ONE, 2005
... The caspase-8 inhibitor (Ac-IETD-CHO) and the caspase-9 inhibitor (Z-LEHD-fmk) were purchased from BD Biosciences (San Diego, CA) ...
Puerarin Decreases Lens Epithelium Cell Apoptosis Induced Partly By Peroxynitrite In Diabetic Rats.
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Morty Rory Edward, In PLoS ONE, 2005
... A Cytochrome c Releasing Apoptosis Assay Kit and Caspase-9 Colorimetric Assay Kit were purchased from Biovision (Mountain View, CA, USA) ...
Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity
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Chen Chin-Tin et al., In Molecular Cancer, 2005
... Anti-phospho-JNK antibody, Caspase-3/CPP32 and Caspase-9 fluorometric assay kits were purchased from BioVision (Mountain View, CA, USA) ...
Necrotic death as a cell fate.
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Wu Gen Sheng, In PLoS ONE, 2005
... Antibodies against Bak, Bcl-xl and Caspase-9 were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes
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Stephanou Anastasis et al., In Biochemical and Biophysical Research Communications, 2004
... was from Upstate, Cambridge, UK, caspase-9 was from Santa Cruz Biotechnology, CA, USA and GAPDH ...
Combination of low-dose cisplatin and recombinant xenogeneic endoglin as a vaccine induces synergistic antitumor activities
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Yang J et al., In Cancer Gene Therapy, 2003
... The antibodies specific for Bid, caspase-3, caspase-8, caspase-9 and PARP were purchased from Cell Signaling (Shanghai, China) ...
Apoptosis pathway in cancer and cancer therapy
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Fahmy Hesham et al., In Marine Drugs, 2003
... Mouse monoclonal antibodies against cleaved-PARP, cleaved-Caspase-8 and rabbit monoclonal antibodies against cleaved-Caspase-3, and cleaved-Caspase-9 were purchased from Cell Signaling (Danvers, MA, USA) ...
Mitogen-activated protein kinase pathways defend against bacterial pore-forming toxins 1.
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Linden Rafael, In PLoS ONE, 2003
... Fluorescein Active caspase-9 staining kit was purchased from Biovision.
Cigarette smoke prevents apoptosis through inhibition of caspase activation and induces necrosis
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Pardo-Galván Marco A et al., In Cell Division, 2002
... Monoclonal antibodies against tubulin and caspase-9 were from Sigma Aldrich (ST ...
The BCL2 family: regulators of the cellular life-or-death switch
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Chung Jing-Gung et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2001
... Polyclonal antibodies specific for caspase-3, caspase-8, and caspase-9 were obtained from the Cell Signaling Technology Inc ...
Constitutive activation of nuclear factor-kappaB prevents TRAIL-induced apoptosis in renal cancer cells.
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Ahmad Aamir, In PLoS ONE, 2000
... from Santa Cruz Biotechnology (Santa Cruz, CA); p21, phospho-IκB-α (Ser32), phosphor-NF-κB p65 (Ser536), cleaved caspase-3, caspase-9 and 8 were purchased from Cell Signaling Technology® (Boston, MA); caspase-3 ...
An APAF-1 cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9
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Pittman Randall N. et al., In The Journal of Cell Biology, 1998
... Antibodies to caspase-9 were from Santa Cruz Biotechnology, Inc ...
Regulation of the expression and processing of caspase-12
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Vandenabeele Peter et al., In The Journal of Cell Biology, 1997
... Anti–murine caspase-9 antibody was from New England Biolabs, Inc ...
Proteins C and NS4B of the flavivirus Kunjin translocate independently into the nucleus.
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Weiner David B. et al., In Emerging Infectious Diseases, 1996
... caspase-9) construct, and cleavage of procaspase-9 protein was determined by Western blot analysis with antihuman caspase-9 antibody (MBL, Nagoya, Japan) ...
Anti-Fas IgG1 antibodies recognizing the same epitope of Fas/APO-1 mediate different biological effects in vitro.
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Kanellopoulos Jean, In PLoS ONE, 1996
... Z-DEVD-FMK (caspase-3 inhibitor), Z-LEVD-FMK (caspase-4 inhibitor), Z-IETD-FMK (caspase-8 inhibitor), and Z-LEHD-FMK (caspase-9 inhibitor) were purchased from BioVision (Mountain View, CA, USA) ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
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Pereira T S et al., In Cell Death & Disease, 1994
... (1:1000, #9662, Cell Signaling Technology, Danvers, MA, USA), anti-Cleaved Caspase-3 (1:250, #9661, Cell Signaling Technology), anti-Caspase-9 (1:500, #9504, Cell Signaling Technology), anti-Cleaved Caspase-9 (1:250, ...
Stages of embryonic development of the zebrafish.
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Hotchin Neil, In PLoS ONE, 1994
... purchased from Upstate Biotechnology (Waltham, MA); anti-FoxO1a (FKHR), anti-phospho-FoxO1a (FKHR, Ser256), anti-cleaved caspase-3, anti-caspase-8, and anti-caspase-9 were purchased from Cell Signaling Technology (Beverly, MA); and ...
Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.
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Wu Xiaolin, In PLoS ONE, 1992
... U0126, LY294002 and antibodies for phospho-ERK1/2, phospho-c-Raf (Ser-259), phosphor-Akt (Ser-473), caspase-3 and caspase-9 were obtained from Cell Signaling Technology (Beverly, MA) ...
α-Toxin is a mediator of Staphylococcus aureus–induced cell death and activates caspases via the intrinsic death pathway independently of death receptor signaling
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Jänicke Reiner U. et al., In The Journal of Cell Biology, 1991
... The polyclonal goat and rabbit antibodies recognizing caspase-3 and caspase-9 were from R&D Systems and New England Biolabs, Inc., respectively ...
Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors
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Mohammad Ramzi M et al., In Molecular Cancer, 1983
... Primary antibodies specific for Caspase-3, Caspase-9, PARP, p-IκBα and IκBα were obtained from Cell Signaling, (Danvers, MA) ...
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications
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Breier Albert et al., In International Journal of Molecular Sciences, 1978
... CA, USA), anti-phospho-Akt kinase (reacts with Ser473-phosphorylated Akt kinase), anti-caspase-3, anti-cleaved caspase-3, anti-caspase-9, and anti-cleaved caspase-9 (all from Cell Signaling Technology Inc., Danvers, MA, ...
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