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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Caspase 8, apoptosis-related cysteine peptidase

caspase-8, xCaspase 8
Top mentioned proteins: PrP, caspase-3, caspase-9, bcl-2, V1a
Papers using caspase-8 antibodies
In TNF-stimulated cells, RIPK1 promotes cell survival by stabilizing TRAF2 and cIAP1, which limits induction of non-canonical NF-{kappa}B and activation of caspase-8
Supplier
Vanden Berghe T et al., In Cell Death & Disease, 2010
... -actin (Clone C4, MP Biomedicals Europe NV, Illkirch, France); anti-caspase-8 (1G12, Alexis, Enzo Life Sciences, Zandhoven, Belgium); anti-RIP1 (610459, BD Biosciences, Franklin Lakes, NJ, USA); ...
Downregulation of nuclear factor-kappaB p65 subunit by small interfering RNA synergizes with gemcitabine to inhibit the growth of pancreatic cancer.
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Bauer Joseph Alan, In PLoS ONE, 2009
... The anti-caspase-8 AB was purchased from Cell Signaling Inc., Massachusetts, USA ...
Involvement of c-FLIP and survivin down-regulation in flexible heteroarotinoid-induced apoptosis and enhancement of TRAIL-initiated apoptosis in lung cancer cells.
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Jin Dong-Yan, In PLoS ONE, 2007
... Antibody to poly-(ADP-ribose)-polymerase was obtained from Boehringer Mannheim (Indianapolis, IN), antibodies to caspase-3, caspase-8 and CD95L were from BD Biosciences (San Diego, CA), antibodies ...
Distinct signaling pathways in TRAIL- versus tumor necrosis factor-induced apoptosis
Supplier
Jeremias I et al., In Cell Death & Disease, 2005
... -caspase 8 (Enzo Life Sciences, Farmingdale, NY, USA), caspase-8 (N-term) rabbit (Epitomics Inc., Burlingame, CA, USA), ...
Mimicking phosphorylation of alphaB-crystallin on serine-59 is necessary and sufficient to provide maximal protection of cardiac myocytes from apoptosis
Supplier
Ohlmann Andreas, In PLoS ONE, 2002
... -4, -6, -7 and -12 and histone H3 antibodies as well as monoclonal mouse anti-human caspase-8 and -9 antibodies from Cell Signaling (Danvers, MA, USA); FITC-conjugated ...
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Papers on caspase-8
5-Fluorouracil-Induced Apoptosis Changes in Cultured Corneal Epithelial Cells.
New
Hong et al., Kao-hsiung, Taiwan. In J Ocul Pharmacol Ther, Feb 2016
Pretreatment with a general caspase inhibitor (Z-VAD-FMK), a caspase-8 inhibitor (Z-IETD-FMK), and a caspase-9 inhibitor (Z-LEHD-FMK) reversed 5-FU-induced cellular damage.
Cooperative TRAIL production mediates IFNα/Smac mimetic-induced cell death in TNFα-resistant solid cancer cells.
New
Fulda et al., Frankfurt am Main, Germany. In Oncotarget, Feb 2016
Mechanistic studies show that IFNα/BV6 cotreatment promotes the formation of a caspase-8-activating complex together with the adaptor protein FADD and RIP1.
The probiotic Propionibacterium freudenreichii as a new adjuvant for TRAIL-based therapy in colorectal cancer.
New
Jan et al., Rennes, France. In Oncotarget, Feb 2016
The revealed synergistic pro-apoptotic effect, depending on both death receptors (TRAIL-R1/DR4, TRAIL-R2/DR5) and caspases (caspase-8, -9 and -3) activation, was lethal on cancer cells but not on normal human intestinal epithelial cells (HIEC), and was inhibited by Bcl-2 expression.
Ophiopogonin D inhibits cell proliferation, causes cell cycle arrest at G2/M, and induces apoptosis in human breast carcinoma MCF-7 cells.
New
Huang et al., Shanghai, China. In J Integr Med, Jan 2016
Furthermore, activation of caspase-8 and caspase-9 was involved in ophiopogonin D-induced apoptosis.
Treatment of chronic kidney disease using a traditional Chinese medicine, Flos Abelmoschus manihot (Linnaeus) Medicus (Malvaceae).
Review
New
Chen et al., Beijing, China. In Clin Exp Pharmacol Physiol, Jan 2016
The renoprotective effects of Flos A. manihot are related to inhibition of caspase-3 and caspase-8 overexpression, reduction of the infiltration of ED1+ and ED3+ macrophages, downregulation of oxidative stress, inhibition of the p38 mitogen-activated protein kinase and serine/threonine kinase pathways and suppression of transforming growth factor-β1 and tumour necrosis factor-α expression.
α-Carboline derivative TJY-16 inhibits tumor growth by inducing G2/M cell cycle arrest in glioma cells.
New
Gean et al., Tainan City, Taiwan. In J Biomed Sci, Dec 2015
The activation of caspase-8 and depolarization of mitochondrial membrane potential (ΔΨm) indicated that both extrinsic and intrinsic apoptotic pathways were involved in TJY-16-induced apoptosis.
Cell death induced by endoplasmic reticulum stress.
Review
New
Muñoz-Pinedo et al., l'Hospitalet de Llobregat, Spain. In Febs J, Dec 2015
In addition, endoplasmic reticulum stress and proteotoxic stress have been shown to induce TRAIL receptors and activation of caspase-8.
RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.
New
Impact
Albert et al., Paris, France. In Science, Nov 2015
To define how different forms of programmed cell death influence immunity, we established models of necroptosis and apoptosis, in which dying cells are generated by receptor-interacting protein kinase-3 and caspase-8 dimerization, respectively.
A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity.
New
Impact
Ma et al., San Francisco, United States. In Immunity, Feb 2015
Pro-IL-1β also co-immunoprecipitates with RIPK1, RIPK3, caspase-1, and caspase-8 in a complex that is modified with K63-linked and unanchored polyubiquitin.
Dysfunctional HIV-specific CD8+ T cell proliferation is associated with increased caspase-8 activity and mediated by necroptosis.
Impact
Walker et al., Cambridge, United States. In Immunity, 2015
We analyzed gene expression profiles from antigen-stimulated HIV-specific CD8(+) T cells from patients with controlled and uncontrolled infection and identified caspase-8 as a correlate of dysfunctional CD8(+) T cell proliferation.
Myeloid-derived suppressor activity is mediated by monocytic lineages maintained by continuous inhibition of extrinsic and intrinsic death pathways.
Impact
Murray et al., Memphis, United States. In Immunity, 2015
Using genetic manipulation of cell death pathways, we found the monocytic suppressor-cell subset, but not the granulocytic subset, requires continuous c-FLIP expression to prevent caspase-8-dependent, RIPK3-independent cell death.
Dietary modulation of the microbiome affects autoinflammatory disease.
Impact
Kanneganti et al., Memphis, United States. In Nature, 2015
Collectively, this work reveals diet-associated changes in the intestinal microbiome as a crucial factor regulating inflammasome- and caspase-8-mediated maturation of IL-1β and osteomyelitis in Pstpip2(cmo) mice.
Necroptotic Cell Death Signaling and Execution Pathway: Lessons from Knockout Mice.
Review
Enns et al., São Paulo, Brazil. In Mediators Inflamm, 2014
Studies on multiple double- and triple- knockout mice identified caspase-8, flip, and fadd genes as key regulators of embryonic lethality and inflammation.
DED or alive: assembly and regulation of the death effector domain complexes.
Review
Longley et al., Belfast, United Kingdom. In Cell Death Dis, 2014
Death effector domains (DEDs) are protein-protein interaction domains initially identified in proteins such as FADD, FLIP and caspase-8 involved in regulating apoptosis.
FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP.
Review
Nakano et al., Tokyo, Japan. In Int J Mol Sci, 2014
cFLIP (cellular FLICE-like inhibitory protein) is structurally related to caspase-8 but lacks proteolytic activity due to multiple amino acid substitutions of catalytically important residues.
Developmental cell death during Xenopus metamorphosis involves BID cleavage and caspase 2 and 8 activation.
GeneRIF
Mazabraud et al., Orsay, France. In Dev Dyn, 2006
tail regression at metamorphosis implicates an apoptotic pathway inducible by T(3) hormone in an organ autonomous manner and involving the cell death executioners BH3 interacting domain death agonist and Caspases-2 and -8
Occurrence of pre-MBT synthesis of caspase-8 mRNA and activation of caspase-8 prior to execution of SAMDC (S-adenosylmethionine decarboxylase)-induced, but not p53-induced, apoptosis in Xenopus late blastulae.
GeneRIF
Yaoita et al., Tokyo, Japan. In Biochem Biophys Res Commun, 2005
Furthermore, while activities to process procaspase-8 and procaspase-9 appeared in SAMDC-overexpressed apoptotic embryos, the activity to process procaspase-8 did not appear in p53-overexpressed apoptotic embryos.
More papers using caspase-8 antibodies
Retroactive pathway involving mitochondria in electroloaded cytochrome c-induced apoptosis. Protective properties of Bcl-2 and Bcl-XL.
Supplier
Rieux-Laucat Frederic, In PLoS ONE, 2002
... Bachem (Voisins-Le-Bretonneux, France); monoclonal anti-FADD (clone A66-2; 0.5 µg/mL), anti-RIP (clone G322-2, 0.25 µg/mL) and anti-caspase-8 (clone B9-2; 0.5 µg/mL) antibodies were from BD Biosciences (Le Pont-de-Claix, France); monoclonal ...
Regulation of Lymphocyte Apoptosis by Interferon Regulatory Factor 4 (IRF-4)
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Pernis Alessandra B. et al., In The Journal of Experimental Medicine, 2001
... , Fas, FasL, CD4, CD62L, CD45RB, Vβ8, and rabbit polyclonal antisera against human caspase-8, -9, and -3, were purchased from BD Biosciences.
Functional P2Y2 nucleotide receptors mediate uridine s'-triphosphate-induced intimal hyperplasia in collared rabbit carotid arteries
Supplier
Weisman Gary A. et al., In Purinergic Signalling, 2001
... Rabbit anti-rat caspase-8 antibody was obtained from Biovision Inc ...
The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment
Supplier
Lane J D et al., In Cell Death & Disease, 2000
... The following antibodies were also used: monoclonal anti-PARP (Calbiochem), polyclonal anti-cleaved PARP (Promega, Southampton, UK), anti-caspase-8 (Santa Cruz Biotechnology Inc., Santa Cruz, CA, ...
Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by Smac/DIABLO release from mitochondria
Supplier
Delia D et al., In British Journal of Cancer, 2000
... (Beverly, MA, USA) (cleaved caspase-3 and cleaved PARP), Alexis Biochemicals (San Diego, CA, USA) (cFLIP, caspase-8), BD Biosciences (San Jose, CA, USA) ...
Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation
Supplier
Green Douglas R. et al., In Nature, 1994
... Mutation of a self-processing site in caspase-8 compromises its apoptotic but not its nonapoptotic functions in bacterial artificial chromosome-transgenic mice ...
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