Modulating caspase activity: beyond the active site.
San Francisco, United States. In Curr Opin Struct Biol, 2013
Surprising new examples of caspase modulation have also been described recently, including a small molecule that binds caspase-6-substrate complexes uncompetitively and a short peptide that stabilizes an inactive, tetrameric form of procaspase-6.
Review: ototoxic characteristics of platinum antitumor drugs.
Buffalo, United States. In Anat Rec (hoboken), 2012
Combined treatment with ethacrynic acid (a loop diuretic) and cisplatin results in rapid apoptotic hair cell death characterized by upregulation of initiator caspase-8 and membrane death receptor, TRADD, followed by downstream executioners, caspase-3 and caspase-6.