Evidence for caspase-dependent programmed cell death along with repair processes in affected skeletal muscle fibres in patients with mitochondrial disorders.
Verona, Italy. In Clin Sci (lond), Mar 2016
We documented that in affected muscle fibres, nuclear chromatin is condensed in lumpy irregular masses and cytochrome c is released into the cytosol to activate, along with Apaf-1 (apoptotic protease-activating factor 1), caspase 9 that, in turn, activates effector caspase 3, caspase 6, and caspase 7, suggesting the execution of the intrinsic apoptotic pathway.
Modulating caspase activity: beyond the active site.
San Francisco, United States. In Curr Opin Struct Biol, 2013
Surprising new examples of caspase modulation have also been described recently, including a small molecule that binds caspase-6-substrate complexes uncompetitively and a short peptide that stabilizes an inactive, tetrameric form of procaspase-6.