Pyroptosis: Caspase-11 Unlocks the Gates of Death.
Lausanne, Switzerland. In Immunity, Dec 2015
In this issue of Immunity, Núñez and colleagues report that caspase-11 cleaves the transmembrane channel pannexin-1, causing an efflux of cellular ATP that promotes a P2X7 receptor-dependent pyroptosis.
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
San Francisco, United States. In Nature, Nov 2015
Intracellular lipopolysaccharide from Gram-negative bacteria including Escherichia coli, Salmonella typhimurium, Shigella flexneri, and Burkholderia thailandensis activates mouse caspase-11, causing pyroptotic cell death, interleukin-1β processing, and lethal septic shock.
The Role of Stefin B in Neuro-inflammation.
Ljubljana, Slovenia. In Front Cell Neurosci, 2014
In our recent work, we demonstrated that stefin B-deficient mice were significantly more sensitive to the lethal lipopolysaccharide (LPS)-induced sepsis, due to increased caspase-11 expression and secreted higher amounts of pro-inflammatory cytokines IL-1β and IL-18.
Caspase-4 is required for activation of inflammasomes.
Zürich, Switzerland. In J Immunol, 2012
Caspase-4 expression is essential for efficient nucleotide-binding domain leucine-rich repeat containing, Pyrin domain containing-3 and for absent in melanoma 2 inflammasome-dependent proIL-1beta activation in macrophages