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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Caspase 14, apoptosis-related cysteine peptidase

caspase-14
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, Filaggrin, CAN, cytokeratin, LOR
Papers on caspase-14
Luteolin induces caspase-14-mediated terminal differentiation in human epidermal keratinocytes.
New
Kumar et al., Tyler, United States. In In Vitro Cell Dev Biol Anim, Nov 2015
Recent studies have demonstrated the role of caspase-14 in terminally differentiated keratinocytes, and its expression may decrease the magnitude of tumors in the epidermis.
Colonization of epidermal tissue by Staphylococcus aureus produces localized hypoxia and stimulates secretion of antioxidant and caspase-14 proteins.
New
Call et al., Pullman, United States. In Infect Immun, Aug 2015
Caspase-14 was also elevated significantly in the media from the colonized explants.
Pilot study on the bioactivity of vitamin d in the skin after oral supplementation.
New
Chow et al., Bethesda, United States. In Cancer Prev Res (phila), Jun 2015
Caspase-14 expression at the basal layer in PD skin samples was the only epidermal differentiation marker that was significantly increased (49%, P < 0.0001).
Comparative genomics reveals conservation of filaggrin and loss of caspase-14 in dolphins.
New
Eckhart et al., Vienna, Austria. In Exp Dermatol, May 2015
Among filaggrin-processing proteases, aspartic peptidase retroviral-like 1 (ASPRV1), also known as saspase, has been conserved, whereas caspase-14 has been lost in all cetaceans investigated.
S100A7 acts as a dual regulator in promoting proliferation and suppressing squamous differentiation through GATA-3/caspase-14 pathway in A431 cells.
New
Xiao et al., Beijing, China. In Exp Dermatol, May 2015
In this study, we demonstrated that the overexpression of S100A7 in A431 cells significantly promoted cell proliferation in vitro and tumor growth in vivo, whereas it suppressed the expression of GATA-3, caspase-14 and three squamous differentiation markers, keratin-1, TG-1 and involucrin.
Skin dryness in apparently healthy human skin is associated with decreased expression of bleomycin hydrolase in the stratum corneum.
New
Lee et al., South Korea. In Clin Exp Dermatol, Apr 2015
Expression of the proteases caspase-14, calpain-1 and bleomycin hydrolase was measured by western blotting.
Effect of Standardized Boesenbergia pandurata Extract and Its Active Compound Panduratin A on Skin Hydration and Barrier Function in Human Epidermal Keratinocytes.
New
Hwang et al., Seoul, South Korea. In Prev Nutr Food Sci, Mar 2015
Proteases, including matriptase and prostasin, stimulate the generation of filaggrin from profilaggrin and caspase-14 plays a role in the degradation of filaggrin.
Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation.
New
Afaq et al., Birmingham, United States. In Br J Dermatol, Feb 2015
We have shown that treatment of reconstituted human skin with delphinidin, an anthocyanidin, present in pigmented fruits and vegetables, increased the expression and processing of caspase-14, which is involved in cornification.
In a three-dimensional reconstructed human epidermis filaggrin-2 is essential for proper cornification.
Simon et al., Toulouse, France. In Cell Death Dis, 2014
However, we observed reduced proteolytic processing of corneodesmosin, hornerin and filaggrin in parallel with reduced amounts of caspase-14 and bleomycin hydrolase.
Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis.
Mukhtar et al., Madison, United States. In Skin Pharmacol Physiol, 2014
RESULTS: Our data show that treatment of PSE with delphinidin induced (1) cornification without affecting apoptosis and (2) the mRNA and protein expression of markers of differentiation (caspase-14, filaggrin, loricrin, involucrin).
The stratum corneum: the rampart of the mammalian body.
Review
Yoon et al., Tokyo, Japan. In Vet Dermatol, 2013
STRUCTURES AND FUNCTIONS: The corneocyte cytoskeleton contains tight bundles of keratin intermediate filaments aggregated with filaggrin monomers, which are subsequently degraded into natural moisturizing compounds by various proteases, including caspase 14.
Cysteine proteases: mode of action and role in epidermal differentiation.
Review
Philpott et al., London, United Kingdom. In Cell Tissue Res, 2013
In addition, caspase-14 has now been shown to play a major part in epidermal maturation.
Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia.
GeneRIF
Kang et al., Seoul, South Korea. In Hum Immunol, 2012
genetic polynorphism is associated with the risk of childhood leukemia
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.
GeneRIF
Declercq et al., Gent, Belgium. In J Invest Dermatol, 2011
Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin.
Gata-3 negatively regulates the tumor-initiating capacity of mammary luminal progenitor cells and targets the putative tumor suppressor caspase-14.
GeneRIF
Visvader et al., Australia. In Mol Cell Biol, 2011
Transcript profiling studies identified caspase-14 as a novel downstream target of Gata-3, in keeping with its roles in differentiation and tumorigenesis.
Regulation of caspase 14 expression in keratinocytes by inflammatory cytokines--a possible link between reduced skin barrier function and inflammation?
GeneRIF
Vestergaard et al., Ã…rhus, Denmark. In Exp Dermatol, 2011
Regulation of caspase 14 levels provides a possible link between impaired skin barrier function and inflammatory reactions in skin diseases such as atopic dermatitis and may offer an explanation to the skin barrier dysfunction in inflamed skin lesions.
Caspase-14 is an anti-apoptotic protein targeting apoptosis-inducing factor in lung adenocarcinomas.
GeneRIF
Ko et al., Taipei, Taiwan. In Oncol Rep, 2011
Casp-14 overexpression correlated with tumor stage, cell differentiation and lymphovascular involvement, suggesting that casp-14 was associated with tumor cell growth and metastatic potential.
Caspase-14 reveals its secrets.
Review
Declercq et al., Gent, Belgium. In J Cell Biol, 2008
The recent development of caspase-14-deficient mice underscored its importance in the correct degradation of (pro)filaggrin and in the formation of the epidermal barrier that protects against dehydration and UVB radiation.
Keratinocyte proliferation, differentiation, and apoptosis--differential mechanisms of regulation by curcumin, EGCG and apigenin.
Review
Eckert et al., Baltimore, United States. In Toxicol Appl Pharmacol, 2007
Our studies show that (-)-epigallocatechin-3-gallate (EGCG), a green tea-derived polyphenol, acts to enhance the differentiation of normal human keratinocytes as evidenced by its ability to increase involucrin (hINV), transglutaminase type 1 (TG1) and caspase-14 gene expression.
Caspase-14 protects against epidermal UVB photodamage and water loss.
Impact
GeneRIF
Declercq et al., Gent, Belgium. In Nat Cell Biol, 2007
The skin of caspase-14-deficient mice was shiny and lichenified, indicating an altered stratum-corneum composition. It contained significantly more alveolar keratohyalin F-granules, the profilaggrin stores.
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