The stratum corneum: the rampart of the mammalian body.
Tokyo, Japan. In Vet Dermatol, 2013
STRUCTURES AND FUNCTIONS: The corneocyte cytoskeleton contains tight bundles of keratin intermediate filaments aggregated with filaggrin monomers, which are subsequently degraded into natural moisturizing compounds by various proteases, including caspase 14.
Caspase-14 reveals its secrets.
Gent, Belgium. In J Cell Biol, 2008
The recent development of caspase-14-deficient mice underscored its importance in the correct degradation of (pro)filaggrin and in the formation of the epidermal barrier that protects against dehydration and UVB radiation.