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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

CASP8 caspase 8, apoptosis-related cysteine peptidase

Caspase 8
Top mentioned proteins: PrP, V1a, bcl-2, CAN, Bax
Papers using Caspase 8 antibodies
Improving outcome of chemotherapy of metastatic breast cancer by docosahexaenoic acid: a phase II trial.
Supplier
Bauer Joseph Alan, In PLoS ONE, 2008
... Scramble siRNA and caspase 8-specific siRNA were obtained from Santa Cruz Biotechnology, Inc ...
Cell-autonomous and non-cell-autonomous functions of caspase-8.
Supplier
Ferreira Sergio T., In PLoS ONE, 2007
... Generation of mouse line with neuronal ablation of caspase 8The generation and characterization of the CRE3 transgenic line were summarized elsewhere ...
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis.
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Bergmann Andreas, In PLoS ONE, 2006
... The caspase 3 assay was obtained from Promega, the caspase 8 substrate Acetyl-Ile-Glu-Pro-Asp-AMC (Ac-IEID-AMC) was purchased from Bachem (Heidelberg, Germany) ...
Peroxisome proliferator-activated receptor-beta/delta inhibits epidermal cell proliferation by down-regulation of kinase activity.
Supplier
Buday Laszlo, In PLoS ONE, 2004
... Caspase 8 (Z-IETD-FMK) inhibitor was from Bachem (Heidelberg, Germany) ...
Growing roles for the mTOR pathway
Supplier
Wang Aiyuan et al., In Molecular Cancer, 2004
... Polyclonal antibodies to AKT and cleaved caspase 8 were from Cell Signaling Technology (Beverly, MA, USA) ...
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Papers on Caspase 8
The anti-tumor activity and mechanism of alkaloids from Aconitum szechenyianum Gay.
New
Wang et al., China. In Bioorg Med Chem Lett, Feb 2016
Furthermore, ASA could up-regulate TNF-R1 and DR5 via activation of p38 MAPK, thereby activating caspase 8, revealing the death receptor pathway was also involved in this process.
Repurposing L-Menthol for Systems Medicine and Cancer Therapeutics? L-Menthol Induces Apoptosis through Caspase 10 and by Suppressing HSP90.
New
Shasany et al., Lucknow, India. In Omics, Jan 2016
The microarray analysis identified caspase 10 as the important initiator caspase, instead of caspase 8.
Dual modulation of Ras-Mnk and PI3K-AKT-mTOR pathways: A Novel c-FLIP inhibitory mechanism of 3-AWA mediated translational attenuation through dephosphorylation of eIF4E.
New
Goswami et al., New Delhi, India. In Sci Rep, Dec 2015
Moreover, the suppression of c-FLIP due to inhibition of translation initiation complex by 3-AWA enhanced FAS trafficking, BID and caspase 8 cleavage.
Effect of curcumin on TNFR2 and TRAF2 in unilateral ureteral obstruction in rats.
New
Abo-El-Matty et al., Bradford, United Kingdom. In Nutrition, Nov 2015
This TRADD-RIP-TRAF complex causes activation of the antiapoptotic pathway and inhibits caspase 8 activation.
Manipulation of apoptosis and necroptosis signaling by herpesviruses.
Review
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Mocarski et al., Atlanta, United States. In Med Microbiol Immunol, Jun 2015
The pathway is triggered against viruses that block caspase 8.
Increased serum IL-10 in lupus patients promotes apoptosis of T cell subsets via the caspase 8 pathway initiated by Fas signaling.
Review
New
Ji et al., Nanjing, China. In J Biomed Res, May 2015
We sought to investigate the expression of Fas and FasL on T cell surface and caspase 8 involvement in T cell apoptosis promoted by serum IL-10 in systemic lupus erythematosus (SLE) patients.
Birth defects in pregestational diabetes: Defect range, glycemic threshold and pathogenesis.
Review
New
Yang et al., Baltimore, United States. In World J Diabetes, May 2015
Activation of the apoptosis signal-regulating kinase 1 (ASK1)-forkhead transcription factor 3a (FoxO3a)-caspase 8 pathway causes apoptosis in the developing neural tube leading to neural tube defects (NTDs).
Principles and mechanisms of CD95 activation.
Review
Wajant, In Biol Chem, 2014
Moreover, the research on CD95-induced cell death fostered various other discoveries of broad and general relevance in cell biology, for example, the identification of caspase 8 as the initiator caspase of the extrinsic apoptosis pathway.
Early Activation of Apoptosis and Caspase-independent Cell Death Plays an Important Role in Mediating the Cytotoxic and Genotoxic Effects of WP 631 in Ovarian Cancer Cells.
Marczak et al., Łódź, Poland. In Asian Pac J Cancer Prev, 2014
DOX led to the activation of all tested caspases, 8, 9 and 3, whereas WP 631 only induced an increase in caspase 8 activity after 24h of treatment and consequently led to the cleavage of PARP.
A long-awaited merger of the pathways mediating host defence and programmed cell death.
Review
Impact
Blander, New York City, United States. In Nat Rev Immunol, 2014
Molecules such as receptor-interacting protein kinase 1 (RIPK1), RIPK3, FAS-associated death domain protein (FADD), FLICE-like inhibitory protein (FLIP) and caspase 8 - which are associated with different forms of cell death - are incorporated into compatible and exceedingly dynamic Toll-like receptor, NOD-like receptor and RIG-I-like receptor signalling modules.
A20--an omnipotent protein in the liver: prometheus myth resolved?
Review
Ferran et al., In Adv Exp Med Biol, 2013
The molecular basis for A20's hepatoprotective functions were partially resolved and include blockade of NF-kappaB activation in support of its anti-inflammatory function, inhibition of pro-caspase 8 cleavage in support of its anti-apoptotic function, increasing Peroxisome Proliferator Activated Receptor alpha (PPARalpha) expression in support of its anti-oxidant function, and decreasing Cyclin Dependent Kinase Inhibitor p21 while boosting IL-6/STAT3 proliferative signals as part of its pro-regenerative function.
Poly IC triggers a cathepsin D- and IPS-1-dependent pathway to enhance cytokine production and mediate dendritic cell necroptosis.
Impact
Akira et al., Ōsaka, Japan. In Immunity, 2013
This interaction facilitated cathepsin D cleavage of caspase 8 and the activation of the transcription factor NF-κB, resulting in enhanced cytokine production.
Viral infection and the evolution of caspase 8-regulated apoptotic and necrotic death pathways.
Review
Impact
Kaiser et al., Atlanta, United States. In Nat Rev Immunol, 2012
Pathogens specifically target both the caspase 8-dependent apoptotic cell death pathway and the necrotic cell death pathway that is dependent on receptor-interacting protein 1 (RIP1; also known as RIPK1) and RIP3 (also known as RIPK3).
Caspase 8 inhibits programmed necrosis by processing CYLD.
Impact
Ting et al., New York City, United States. In Nat Cell Biol, 2011
Caspase 8 initiates apoptosis downstream of TNF death receptors by undergoing autocleavage and processing the executioner caspase 3 (ref.
Mesenchymal stem cell-based tissue regeneration is governed by recipient T lymphocytes via IFN-γ and TNF-α.
Impact
Shi et al., Los Angeles, United States. In Nat Med, 2011
We also found that, through inhibition of nuclear factor κB (NF-κB), TNF-α converts the signaling of the IFN-γ-activated, nonapoptotic form of TNF receptor superfamily member 6 (Fas) in BMMSCs to a caspase 3- and caspase 8-associated proapoptotic cascade, resulting in the apoptosis of these cells.
Endothelial cell apoptosis induced by bacteria-activated platelets requires caspase-8 and -9 and generation of reactive oxygen species.
GeneRIF
Czuprynski et al., Madison, United States. In Thromb Haemost, 2008
Endothelial cell apoptosis by H. somnus-activated platelets required activation of both caspase-8 and caspase-9.
More papers using Caspase 8 antibodies
Chemotherapy enhances TNF-related apoptosis-inducing ligand DISC assembly in HT29 human colon cancer cells.
Supplier
Belkhiri Abbes, In PLoS ONE, 2002
... Mouse antibodies to caspase 8 (clone 12F5, Alexis Biochemicals, Covalab, Villeurbanne, France), cytochrome c (clone ...
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