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Caspase 7, apoptosis-related cysteine peptidase

Caspase 7, CASP7
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, caspase-3, CAN, caspase-9, bcl-2
Papers using Caspase 7 antibodies
Elucidation of CXCR7-mediated signaling events and inhibition of CXCR4-mediated tumor cell transendothelial migration by CXCR7 ligands.
Supplier
Cookson Mark R., In PLoS ONE, 2008
... , cleaved poly-ADP ribose polymerase (PARP), cleaved caspase-3, cleaved caspase-9, cleaved caspase-8, and cleaved caspase-7 were from (Cell Signaling, Danvers, MA, USA) ...
Development of reverse genetics systems for bluetongue virus: recovery of infectious virus from synthetic RNA transcripts
Supplier
Roy Polly et al., In Virology Journal, 2007
... Active caspase-8 (18C8 #9496), caspase-9 (#9501) and caspase-7 (#9492) antibodies were purchase from Cell Signaling.
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death
Supplier
Tohyama Masaya et al., In The Journal of Cell Biology, 1996
BD Biosciences), anti–glyceraldehyde-3-phosphate dehydrogenase mAb (6G7; Biogenesis), anti–caspase-3 mAb (19; Transduction), anti–caspase-7 mAb (4G2; MBL International Corporation), anti–β-actin mAb ...
Papers on Caspase 7
The Inhibition of the Apoptosis Pathway by the Coxiella burnetii Effector Protein CaeA requires the EK Repetition Motif, but is Independent of Survivin.
New
Lührmann et al., Erlangen, Germany. In Virulence, Feb 2016
Ectopic expression of CaeA reduced extrinsic apoptosis and prevented the cleavage of the executioner caspase 7, but did not impair the activation of initiator caspase 9. CaeA expression resulted in an up-regulation of survivin (an inhibitor of activated caspases), which, however, was not causal for the anti-apoptotic effect of CaeA.
Prospero homeobox 1 mediates the progression of gastric cancer by inducing tumor cell proliferation and lymphangiogenesis.
New
Joo et al., Kwangju, South Korea. In Gastric Cancer, Feb 2016
RESULTS: PROX1 knockdown induced apoptosis by activating cleaved caspase-3, caspase-7, caspase-9, and poly(ADP-ribose) polymerase, and by decreasing the expression of anti-apoptotic proteins Bcl-2 and Bcl-xL.
Axon guidance molecule Semaphorin3A is a novel tumor suppressor in head and neck squamous cell carcinoma.
New
Song et al., Nanjing, China. In Oncotarget, Feb 2016
Both genetic and recombinant SEMA3A protein inhibited cell proliferation and colony formation and induced apoptosis, accompanied by decreased cyclin E, cyclin D, CDK2, CDK4 and CDK6 and increased P21, P27, activated caspase-5 and caspase-7.
Ambiguine I Isonitrile from Fischerella ambigua Induces Caspase-Independent Cell Death in MCF-7 Hormone Dependent Breast Cancer Cells.
New
Carcache de Blanco et al., Chicago, United States. In Int J Cancer Res (tortola), Mar 2015
The apoptotic effect was associated with block in G1-phase of the cell cycle in treated cells; however, cell death was induced independently of caspase-7.
Caspase-1: the inflammasome and beyond.
Review
Beer et al., Zürich, Switzerland. In Innate Immun, 2014
The physiologic effects of processing of other downstream targets, such as proteins involved in glycolysis or activation of caspase-7, are less well understood.
Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia.
GeneRIF
Kang et al., Seoul, South Korea. In Hum Immunol, 2012
genetic polynorphism is associated with the risk of childhood leukemia
X-linked inhibitor of apoptosis protein mediates neddylation by itself but does not function as a NEDD8-E3 ligase for caspase-7.
GeneRIF
Kamada et al., Kōbe, Japan. In Febs Lett, 2012
XIAP does not function as a NEDD8-E3 ligase for caspase-7 in vivo
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
Impact
Spritz et al., Aurora, United States. In Nat Genet, 2012
× 10(-13)), IFIH1 (P = 4.91 × 10(-15)), CD80 (P = 3.78 × 10(-10)), CLNK (P = 1.56 × 10(-8)), BACH2 (P = 2.53 × 10(-8)), SLA (P = 1.58 × 10(-8)), CASP7 (P = 3.56 × 10(-8)), CD44 (P = 1.78 × 10(-9)), IKZF4 (P = 2.75 × 10(-14)), SH2B3 (P = 3.54 × 10(-18)) and TOB2 (P = 6.81 × 10(-10)).
Inflammasome-activated caspase 7 cleaves PARP1 to enhance the expression of a subset of NF-κB target genes.
GeneRIF
Hottiger et al., Zürich, Switzerland. In Mol Cell, 2012
An apoptosis-independent regulatory role for caspase 7-mediated PARP1 cleavage in proinflammatory gene expression is discussed.
Caspase-7 uses an exosite to promote poly(ADP ribose) polymerase 1 proteolysis.
GeneRIF
Denault et al., Sherbrooke, Canada. In Proc Natl Acad Sci U S A, 2012
Cellular expression of caspase-7 lacking the critical lysine residues resulted in less-efficient PARP and p23 cleavage compared with cells expressing the wild-type peptidase.
The orexin receptor OX(1)R in colon cancer: a promising therapeutic target and a new paradigm in G protein-coupled receptor signalling through ITIMs.
Review
Voisin et al., Paris, France. In Br J Pharmacol, 2012
Downstream events include release of cytochrome c from mitochondria and activation of caspase-3 and caspase-7.
Phosphorylation of the transcription factor YY1 by CK2α prevents cleavage by caspase 7 during apoptosis.
GeneRIF
Hurt et al., Tallahassee, United States. In Mol Cell Biol, 2012
identify serine 118 in the transactivation domain of YY1 as the site of CK2alpha phosphorylation, proximal to a caspase 7 cleavage site
Lactobacillus plantarum 299v Prevents Caspase-Dependent Apoptosis In Vitro.
Mack et al., Ottawa, Canada. In Probiotics Antimicrob Proteins, 2011
To assess for cell death, we evaluated TUNEL, multi-caspase, and caspase-3 and caspase-7 activity assays.
Polymorphisms in the CASPASE genes and survival in patients with early-stage non-small-cell lung cancer.
Impact
Park et al., Taegu, South Korea. In J Clin Oncol, 2010
Nine potentially functional polymorphisms in the CASP3, CASP7, CASP8, CASP9, and CASP10 genes were investigated.
Cy5-Glu-Pro-Asp-acyloxymethyl ketone
Review
Leung, Bethesda, United States. In Unknown Journal, 2009
Berger et al. (16) reported that acyloxymethyl ketone peptides exhibited selective inhibition of caspase-3 and caspase-7 (executioner caspases) over caspase-8 and caspase-9 (initiator caspases).
(S)-1-((1-(2-[(18)F]Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)methyl)-5-(2-4-difluorophenoxymethyl-pyrrolidine-1-sulfonyl)isatin
Review
Leung, Bethesda, United States. In Unknown Journal, 2009
Smith et al. (14) reported that isatin sulfonamide analogs exhibited selective inhibition of caspase-3 and caspase-7 (executioner caspases) over caspase-1, -6, and -8 (initiator caspases).
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites.
Impact
Overall et al., Vancouver, Canada. In Nat Biotechnol, 2008
Profiling of HIV protease 1, caspase 3, caspase 7, cathepsins K and G, elastase and thrombin showed that this approach is broadly applicable to all mechanistic classes of endoproteases.
(S)-1-(4-(2-[(18)F]Fluoroethoxy)benzyl)-5-[1-(2-methoxymethyl-pyrrolidinyl)sulfonyl]-1H-indole-2,3-dione
Review
Leung, Bethesda, United States. In Unknown Journal, 2007
Kopka et al. (14) reported that 5-pyrrolidinylsulfonyl isatins exhibited selective inhibition of caspase-3 and caspase-7 (executioner caspases) over caspase-1, -6, and -8 (initiator caspases).
Caspases 3 and 7: key mediators of mitochondrial events of apoptosis.
Impact
GeneRIF
Flavell et al., New Haven, United States. In Science, 2006
data show caspases 3 and 7 are crucial for apoptosis and contribute to some mitochondrial events once thought to lie upstream of effector caspases
IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms.
Impact
Meier et al., London, United Kingdom. In Nat Cell Biol, 2005
Moreover, we demonstrate that the mammalian IAP c-IAP1 interacts with caspase-7 in an exclusively IBM-dependent, but active site pocket-independent, manner that is mechanistically similar to DIAP1.
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