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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 08 Dec 2016.

Caspase 5, apoptosis-related cysteine peptidase

CASP5, caspase-5, ICH3
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010] (from NCBI)
Papers using CASP5 antibodies
Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme*
Supplier
Martin Seamus J. et al., In The Journal of Biological Chemistry, 2008
... Anti-caspase-4 and caspase-5 were purchased from MBL (catalog nos ...
Papers on CASP5
Association of caspases with an increased prostate cancer risk in north Indian population.
GeneRIF
Mandal et al., Lucknow, India. In Dna Cell Biol, 2012
Data suggest a positive association of caspase-3 and diplotype analysis of caspase-5 to be associated with prostate cancer risk.
Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells.
GeneRIF
Elner et al., Ann Arbor, United States. In Invest Ophthalmol Vis Sci, 2011
Mutual activation between caspase-5 and -1 suggests caspase-5 may work predominantly in concert with caspase-1 in modulating retinal pigment epithelium inflammatory responses.
Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians.
GeneRIF
Mandhani et al., Lucknow, India. In Eur J Surg Oncol, 2011
Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians.
Concerted antigen processing of a short viral antigen by human caspase-5 and -10.
GeneRIF
Del Val et al., Madrid, Spain. In J Biol Chem, 2011
analysis of concerted antigen processing of a short viral antigen by human caspase-5 and -10
Caspase-5 expression is upregulated in lesional psoriatic skin.
GeneRIF
Iversen et al., Ã…rhus, Denmark. In J Invest Dermatol, 2011
Caspase-5 and the inflammasome may have an important role in the inflammatory response in psoriasis.
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