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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Caspase 5, apoptosis-related cysteine peptidase

CASP5, caspase-5, ICH3
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010] (from NCBI)
Top mentioned proteins: PrP, CAN, caspase-4, SET, HAD
Papers using CASP5 antibodies
Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme*
Martin Seamus J. et al., In The Journal of Biological Chemistry, 2008
... Anti-caspase-4 and caspase-5 were purchased from MBL (catalog nos ...
Papers on CASP5
Axon guidance molecule Semaphorin3A is a novel tumor suppressor in head and neck squamous cell carcinoma.
Song et al., Nanjing, China. In Oncotarget, Feb 2016
Both genetic and recombinant SEMA3A protein inhibited cell proliferation and colony formation and induced apoptosis, accompanied by decreased cyclin E, cyclin D, CDK2, CDK4 and CDK6 and increased P21, P27, activated caspase-5 and caspase-7.
Caspase-5 rescues UVB-dependent IL-1β activity by ASC-deficient epidermal keratinocytes.
Wolf et al., München, Germany. In Photodermatol Photoimmunol Photomed, Jan 2016
In the presence of ASC, inflammatory caspase-5 is less relevant for UVB-mediated IL-1β release, and ASC acted as a negative regulator of caspase-5 in keratinocytes.
NLRP3 inflammasome activation downstream of cytoplasmic LPS recognition by both caspase-4 and caspase-5.
Masters et al., Australia. In Eur J Immunol, Oct 2015
Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase-4 and caspase-5.
Potassium efflux fires the canon: Potassium efflux as a common trigger for canonical and noncanonical NLRP3 pathways.
Brough et al., Manchester, United Kingdom. In Eur J Immunol, Oct 2015
Murine caspase-11 and its human orthologues, caspase-4 and caspase-5, activate an inflammatory response following cytoplasmic recognition of cell wall constituents from Gram-negative bacteria, such as LPS.
Analysis of inflammasomes and antiviral sensing components reveals decreased expression of NLRX1 in HIV-positive patients assuming efficient antiretroviral therapy.
Cossarizza et al., Reggio nell'Emilia, Italy. In Aids, Oct 2015
By RT-PCR, using peripheral blood mononuclear cells (PBMCs), we quantified the mRNA expression of 16 genes involved in inflammasome activation and regulation (AIM2, NAIP, PYCARD, CASP1, CASP5, NLRP6, NLRP1, NLRP3, TXNIP, BCL2, NLRC4, PANX1, P2RX7, IL-18, IL-1β, SUGT1) and eight genes involved in IMS (MFN2, MFN1, cGAS, RIG-I, MAVS, NLRX1, RAB32, STING).
Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity.
Shao et al., Beijing, China. In Curr Opin Immunol, Feb 2015
Unexpectedly, biochemical studies reveal that caspase-11 and its human orthologs caspase-4/caspase-5 are LPS receptors themselves.
Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes.
Mortellaro et al., Singapore, Singapore. In Nat Commun, 2014
Here we report that caspase-4 and caspase-5 mediate IL-1α and IL-1β release from human monocytes after LPS stimulation.
Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age.
Dihlmann et al., Heidelberg, Germany. In Immun Ageing, 2014
FINDINGS: Linear regression of real-time qRT-PCR data revealed a significant positive association of gene expression of each of the inflammasome components with age (Pearson correlation coefficients: AIM2: r = 0.245; P = 0.032; NLRP3: r = 0.367; P = 0.001; ASC (PYCARD): r = 0.252; P = 0.027; CASP1: r = 0.296; P = 0.009; CASP5: r = 0.453; P = 0.00003; IL1B: r = 0.247; P = 0.030).
Inflammatory caspases are innate immune receptors for intracellular LPS.
Shao et al., Beijing, China. In Nature, 2014
Human caspase-4 and the mouse homologue caspase-11 (hereafter referred to as caspase-4/11) and also human caspase-5, directly bound to LPS and lipid A with high specificity and affinity.
Complex roles of caspases in the pathogenesis of inflammatory bowel disease.
Neurath et al., Erlangen, Germany. In Gastroenterology, 2013
In particular, caspase-1, caspase-4, caspase-5, and caspase-12 are activated during innate immune responses and participate in the formation of the inflammasome.
Profiling of ileal carcinoids.
Nilsson, Göteborg, Sweden. In Neuroendocrinology, 2012
Candidate genes for targeted therapy included ERBB2/HER2, DAD1, PRKCA, RYBP, CASP1, CASP4, CASP5, VMAT1, RET, APLP1, OR51E1, GPR112, SPOCK1, RUNX1, and MIR133A.
Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization.
Amer et al., Columbus, United States. In Immunity, 2012
Similarly, human caspase-4 and caspase-5, homologs of mouse caspase-11, cooperated to restrict L. pneumophila infection in human macrophages.
Association of caspases with an increased prostate cancer risk in north Indian population.
Mandal et al., Lucknow, India. In Dna Cell Biol, 2012
Data suggest a positive association of caspase-3 and diplotype analysis of caspase-5 to be associated with prostate cancer risk.
Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells.
Elner et al., Ann Arbor, United States. In Invest Ophthalmol Vis Sci, 2011
Mutual activation between caspase-5 and -1 suggests caspase-5 may work predominantly in concert with caspase-1 in modulating retinal pigment epithelium inflammatory responses.
Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians.
Mandhani et al., Lucknow, India. In Eur J Surg Oncol, 2011
Association of death receptor 4, Caspase 3 and 5 gene polymorphism with increased risk to bladder cancer in North Indians.
Concerted antigen processing of a short viral antigen by human caspase-5 and -10.
Del Val et al., Madrid, Spain. In J Biol Chem, 2011
analysis of concerted antigen processing of a short viral antigen by human caspase-5 and -10
Caspase-5 expression is upregulated in lesional psoriatic skin.
Iversen et al., Århus, Denmark. In J Invest Dermatol, 2011
Caspase-5 and the inflammasome may have an important role in the inflammatory response in psoriasis.
Acute neurodegeneration and the inflammasome: central processor for danger signals and the inflammatory response?
Trendelenburg, Berlin, Germany. In J Cereb Blood Flow Metab, 2008
Fortunately, the inflammasome, a multiprotein complex responsible for activating caspase-1 and caspase-5, has recently been characterized.
Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases.
Tschopp et al., Lausanne, Switzerland. In Cell, 2004
Activation of inflammatory caspases, such as caspase-1 and caspase-5, occurs upon assembly of an intracellular complex, designated the inflammasome.
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Tschopp et al., Lausanne, Switzerland. In Immunity, 2004
Here, we report that NALP2 and NALP3 associate with ASC, the CARD-containing protein Cardinal, and caspase-1 (but not caspase-5), thereby forming an inflammasome with high proIL-1beta-processing activity.
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