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CSNK1D casein kinase 1, delta

Casein kinase I delta, CKI-delta, casein kinase 1delta
Top mentioned proteins: CKI, CKIepsilon, ACID, p53, CLOCK
Papers on Casein kinase I delta
Casein kinase 1δ activity: a key element in the zebrafish circadian timing system.
Gothilf et al., Tel Aviv-Yafo, Israel. In Plos One, 2012
However, the post-translational modifications of clock proteins, and in particular the phosphorylation of PER proteins by Casein kinase I delta and epsilon (CK1δ and CK1ε), have so far not been examined in the zebrafish.
Casein kinase I delta controls centrosome positioning during T cell activation.
Gergely et al., Cambridge, United Kingdom. In J Cell Biol, 2011
In this paper, we uncover a critical requirement for the centrosomal casein kinase I delta (CKIδ) in centrosome translocation to the IS.
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.
Simos et al., Lárisa, Greece. In J Cell Sci, 2010
In this work, we investigate the phosphorylation of the N-terminal heterodimerization (PAS) domain of HIF-1alpha and identify Ser247 as a major site of in vitro modification by casein kinase 1delta (CK1delta).
Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms.
Pickard et al., United States. In Psychopharmacology (berl), 2010
INTRODUCTION: Casein kinase I epsilon/delta phosphorylates certain clock-related proteins as part of a complex arrangement of transcriptional/translational feedback loops that comprise the circadian oscillator in mammals.
The DNA-binding activity of mouse DNA methyltransferase 1 is regulated by phosphorylation with casein kinase 1delta/epsilon.
Kameshita et al., Japan. In Biochem J, 2010
When the proteins in this fraction were analysed by LC-MS/MS (liquid chromatography tandem MS), CK1delta/epsilon (casein kinase 1delta/epsilon) was the only protein kinase identified.
Shugoshin-PP2A counteracts casein-kinase-1-dependent cleavage of Rec8 by separase.
Impact
Watanabe et al., Tokyo, Japan. In Nat Cell Biol, 2010
Using a genetic screen for 'anti-shugoshin', we identify Hhp2, an orthologue of casein kinase 1delta/epsilon (CK1), as a factor required for Rec8 cleavage in fission yeast.
Rec8 phosphorylation by casein kinase 1 and Cdc7-Dbf4 kinase regulates cohesin cleavage by separase during meiosis.
Zachariae et al., Oxford, United Kingdom. In Dev Cell, 2010
We show here that multiple phosphorylation sites within Rec8 as well as two different kinases, casein kinase 1delta/epsilon (CK1delta/epsilon) and Dbf4-dependent Cdc7 kinase (DDK), are required for Rec8 cleavage and meiosis I nuclear division.
3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta.
Laufer et al., Tübingen, Germany. In J Med Chem, 2010
In this study, we report on the discovery of isoxazole 1 as a potent dual inhibitor of p38alpha (IC(50) = 0.45 microM) and CK1delta (IC(50) = 0.23 microM).
Casein kinase I delta/epsilon phosphorylates topoisomerase IIalpha at serine-1106 and modulates DNA cleavage activity.
Ganapathi et al., Cleveland, United States. In Nucleic Acids Res, 2009
We previously reported that phosphorylation of topoisomerase (topo) IIalpha at serine-1106 (Ser-1106) regulates enzyme activity and sensitivity to topo II-targeted drugs.
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.
Zollo et al., Napoli, Italy. In Oncogene, 2008
The region of the nm23-h-prune interaction lies between S120 and S125 of nm23, where missense mutants show impaired binding; this region has been highly conserved throughout evolution, and can undergo serine phosphorylation by casein kinase I. Thus, the casein kinase I delta-epsilon specific inhibitor IC261 impairs the formation of the nm23-h-prune complex, which translates 'in vitro' into inhibition of cellular motility in a breast cancer cellular model.
Novel phosphorylation sites in tau from Alzheimer brain support a role for casein kinase 1 in disease pathogenesis.
Anderton et al., London, United Kingdom. In J Biol Chem, 2007
Casein kinase 1delta and glycogen synthase kinase-3beta were each found to phosphorylate numerous sites, and each kinase phosphorylated at least 15 sites that are also phosphorylated in PHF-tau from Alzheimer brain.
Biochemical characterization of a N-terminal fragment (p5) cleaved from fibroblast growth factor-binding protein (FGF-BP) in bovine milk in vitro.
Kawakami et al., Sagamihara, Japan. In Biochim Biophys Acta, 2007
By means of successive gel filtration on a Superdex 30 pg column and Mono S column chromatography, a 5-kDa polypeptide (p5) was highly purified from the low molecular weight (LMW) fraction separated from the partially purified lactoferrin (bLF) fraction of bovine milk, and biochemically characterized as a phosphate acceptor for two protein kinases [cAMP-dependent protein kinase (PKA) and casein kinase 1delta (CK1delta)] in vitro.
Regulation of the nuclear export of the transcription factor NFATc1 by protein kinases after slow fibre type electrical stimulation of adult mouse skeletal muscle fibres.
Schneider et al., Baltimore, United States. In J Physiol, 2007
In these studies, we found that inhibition of either glycogen synthase kinase 3beta (GSK3beta) or casein kinase 1 or 2 (CK1/2) markedly slowed the decay of nuclear NFATc1-GFP after cessation of muscle fibre electrical stimulation, whereas inhibition of casein kinase 1delta, p38 mitogen-activated protein kinase, c-Jun N-terminal kinase and protein kinase A had little effect.
Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.
Virshup et al., Salt Lake City, United States. In Int J Cancer, 2007
The Wnt signaling pathway is critical for embryonic development and is dysregulated in multiple cancers.
Posttranslational mechanisms regulate the mammalian circadian clock.
Impact
Reppert et al., Worcester, United States. In Cell, 2002
We also provide in vivo evidence that casein kinase I delta is a second clock relevant kinase.
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