Casein kinase I delta
Phosphorylation of nm23-H1 by CKI induces its complex formation with h-prune and promotes cell motility.
Napoli, Italy. In Oncogene, 2008
The region of the nm23-h-prune interaction lies between S120 and S125 of nm23, where missense mutants show impaired binding; this region has been highly conserved throughout evolution, and can undergo serine phosphorylation by casein kinase I. Thus, the casein kinase I delta-epsilon specific inhibitor IC261 impairs the formation of the nm23-h-prune complex, which translates 'in vitro' into inhibition of cellular motility in a breast cancer cellular model.