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Carnitine palmitoyltransferase 2

Carnitine O-Palmitoyltransferase
inner mitochondrial membrane protein that converts acylcarnitine to acyl-CoA [RGD, Feb 2006] (from NCBI)
Top mentioned proteins: ACID, Insulin, fibrillin-1, CPT I, HAD
Papers on Carnitine O-Palmitoyltransferase
Abundance of specific mRNA transcripts impacts hatching success in European eel, Anguilla anguilla L.
New
Mazurais et al., Charlottenlund, Denmark. In Comp Biochem Physiol A Mol Integr Physiol, Jan 2016
Previous studies have shown that quantities of the maternal gene products β-tubulin, insulin-like growth factor 2 (igf2), nucleoplasmin (npm2), prohibitin 2 (phb2), phosphatidylinositol glycan biosynthesis class F protein 5 (pigf5), and carnitine O-palmitoyltransferase liver isoform-like 1 (cpt1) are associated with embryonic developmental competence in other teleosts.
Comparative analysis of the hepatopancreas transcriptome of grass carp (Ctenopharyngodon idellus) fed with lard oil and fish oil diets.
New
Du et al., China. In Gene, Aug 2015
Lipid metabolism related genes, such as very long-chain acyl-CoA synthetase (ACSVL),carnitine O-palmitoyltransferase 1 (CPT1) and carnitine-acylcarnitine translocase (CACT), were up-regulated in the FO group.
Comparative proteome analysis of brown adipose tissue in obese C57BL/6J mice using iTRAQ-coupled 2D LC-MS/MS.
Sun et al., Beijing, China. In Plos One, 2014
In this pathway, carnitine O-palmitoyltransferase 2 (CPT2), uncoupling protein 1 (UCP1) and apoptosis-inducing factor 1 (AIF1) were up-regulated significantly by HFD, and they were confirmed by western blotting.
Reversal of obesity-induced hypertriglyceridemia by (R)-α-lipoic acid in ZDF (fa/fa) rats.
Moreau et al., Lincoln, United States. In Biochem Biophys Res Commun, 2013
Feeding LA to ZDF rats (a) corrected severe hypertriglyceridemia, (b) lowered abdominal fat mass, (c) raised circulating fibroblast growth factor-21 and Fgf21 liver gene expression, (d) repressed lipogenic gene expression of ATP-citrate synthase (Acly), acetyl-coA carboxylase 1 (Acaca), fatty acid synthase (Fasn), sn-glycerol-3-phosphate acyltransferase 1 (Gpam), adiponutrin (Pnpla3) in the liver and adipose tissue, (e) decreased hepatic protein levels of ACC1/2, FASN and 5'-AMP-activated protein kinase catalytic subunit α (AMPKα), (f) did not change phospho-AMPKα/AMPKα and phospho-ACC/ACC ratios, (g) stimulated liver gene expression of PPARα target genes carnitine O-palmitoyltransferase 1β (Cpt1b) and acyl-CoA thioesterase 1 (Acot1) but not carnitine O-palmitoyltransferase 1α (Cpt1a).
Lipogenic gene expression profile in patients with gastric cancer.
Hisatomi et al., Nikkō, Japan. In Mol Clin Oncol, 2013
In patients with gastric cancer, carnitine O-palmitoyltransferase type I mRNA and miR-33b were significantly downregulated, suggesting that miR-33b downregulation is mediated by conditions that also affect the expression and/or activity of transcription factors involved in lipogenic gene expression.
Identification of the target proteins of rosiglitazone in 3T3-L1 adipocytes through proteomic analysis of cytosolic and secreted proteins.
Baek et al., Taegu, South Korea. In Mol Cells, 2011
Some differentially expressed proteins in particular, including fatty acid translocase (FAT)/CD36, fatty acid binding protein, lipoprotein lipase, acetyl CoA acyltransferase, carnitine O-palmitoyltransferase 2, sterol carrier protein, adiponectin, and phosphoenolpyruvate carboxykinase could explain the current action mechanism of TZDs.
Proteomic analysis of bovine omental, subcutaneous and intramuscular preadipocytes during in vitro adipogenic differentiation.
Lee et al., Suwŏn, South Korea. In Comp Biochem Physiol Part D Genomics Proteomics, 2010
Most up-regulated proteins like Ubiquinol-cytochrome-c reductase complex core protein I (UQCRC1), ATP synthase D chain, Superoxide dismutase (SOD), Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Sulfotransferase 1A1 (SULT1A1), Carnitine O-palmitoyltransferase 2 (CPT2) and Heat-shock protein beta 1 (HSPB1) across the three depots were found to be associated with lipid metabolism and metabolic activity.
Effect of polymorphisms in candidate genes on reproduction traits in Finnish pig populations.
Vilkki et al., Finland. In J Anim Sci, 2010
In this study we evaluated the impact of single polymorphisms (n = 7) in 7 candidate genes on reproductive efficiency in Finnish Yorkshire (n = 280) and Landrace (n = 271) populations: IGFBP1, IGFBP2, IGFBP3, IGFBP5, CPTIA (carnitine O-palmitoyltransferase I), COX2 (PG-endoperoxide synthase 2, also known as cyclooxygenase-2), and SLC22A5 [organic cation/carnitine transporter 2 (solute carrier family member I), OCTN2].
Partial characterization of a malonyl-CoA-sensitive carnitine O-palmitoyltransferase I from Macrobrachium borellii (Crustacea: Palaemonidae).
Heras et al., La Plata, Argentina. In Comp Biochem Physiol B Biochem Mol Biol, 2009
Carnitine O-palmitoyltransferase I (EC 2.3.1.21;
Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis.
Takamura et al., Kanazawa, Japan. In Hepatology, 2008
Unexpectedly, tranilast ameliorated hepatic steatosis and up-regulated the expression of genes involved in beta-oxidation, such as peroxisome proliferator-activated receptor alpha and carnitine O-palmitoyltransferase-1.
Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog.
GeneRIF
Hennig et al., Basel, Switzerland. In Febs Lett, 2007
The protein interacts with the membrane as a functional monomer and the calculations confirm the presence of a membrane association domain that consists of layers of hydrophobic and positively charged residues.
Crystal structure of rat carnitine palmitoyltransferase II (CPT-II).
GeneRIF
Tong et al., New York City, United States. In Biochem Biophys Res Commun, 2006
surface patch mediates the association of CPT-II with the inner membrane of the mitochondria
Pancreatitis associated with hyperlipoproteinaemia type I in mink (Mustela vison): earliest detectable changes occur in mitochondria of exocrine cells.
Olivecrona et al., Oslo, Norway. In J Comp Pathol, 2006
The activity of the mitochondrial enzyme carnitine O-palmitoyltransferase, essential for the transport of fatty acids into the mitochondria, was lower in the pancreas than in the liver.
The crystal structure of carnitine palmitoyltransferase 2 and implications for diabetes treatment.
GeneRIF
Hennig et al., Basel, Switzerland. In Structure, 2006
crystal structure of carnitine palmitoyltransferase 2
Hepatic gene expression changes in mouse models with liver-specific deletion or global suppression of the NADPH-cytochrome P450 reductase gene. Mechanistic implications for the regulation of microsomal cytochrome P450 and the fatty liver phenotype.
Ding et al., Albany, United States. In J Biol Chem, 2005
Additionally, we observed model-specific gene expression changes, such as the induction of a fatty-acid translocase (Cd36 antigen) and the suppression of carnitine O-palmitoyltransferase 1 (Cpt1a) and acyl-CoA synthetase long chain family member 1 (Acsl1), that are potentially responsible for the severe hepatic lipidosis and an altered fatty acid profile observed in liver-Cpr-null mice.
Identification by mutagenesis of a conserved glutamate (Glu487) residue important for catalytic activity in rat liver carnitine palmitoyltransferase II.
GeneRIF
Woldegiorgis et al., Beaverton, United States. In J Biol Chem, 2002
role of highly conserved C-terminal acidic residues glutamate 487 and glutamate 500 on catalytic activity in liver
C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity.
Kuhajda et al., Baltimore, United States. In Proc Natl Acad Sci U S A, 2002
Etomoxir, an inhibitor of carnitine O-palmitoyltransferase-1 (CPT-1), reversed the increased energy expenditure in DIO mice by inhibiting fatty acid oxidation.
The effect of etomoxir on 24-h substrate oxidation and satiety in humans.
Westerterp-Plantenga et al., Zürich, Switzerland. In Am J Clin Nutr, 2002
BACKGROUND: The carnitine O-palmitoyltransferase I (EC 2.3.1.21)
Effects of extracellular ATP on hepatic fatty acid metabolism.
Castro et al., Madrid, Spain. In Am J Physiol, 1996
However, both carnitine O-palmitoyltransferase I (CPT-I) activity and ketogenesis from palmitate were inhibited in parallel by extracellular ATP.
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