gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Caspase recruitment domain family, member 10

CARMA3, CARD10, Bimp1
The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: BCL10, Eco, NF-kappaB, PrP, CARMA1
Papers on CARMA3
The CBM Complex Underwrites NF-κB Activation to Promote HER2-Associated Tumor Malignancy.
Lin et al., Houston, United States. In Mol Cancer Res, Jan 2016
The CARMA3-BCL10-MALT1 (CBM) complex is required for GPCR- and EGFR-induced NF-κB activation.
Genetic errors of the human caspase recruitment domain-B-cell lymphoma 10-mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity.
Puel et al., Madrid, Spain. In J Allergy Clin Immunol, Nov 2015
Three members of the caspase recruitment domain (CARD) family of adaptors (CARD9, CARD10, and CARD11) are known to form heterotrimers with B-cell lymphoma 10 (BCL10) and mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (MALT1).
CARMA3 regulates the invasion, migration, and apoptosis of non-small cell lung cancer cells by activating NF-кB and suppressing the P38 MAPK signaling pathway.
Qiu et al., Shenyang, China. In Exp Mol Pathol, Nov 2015
UNASSIGNED: In our previous study, CARMA3 overexpression in lung cancer cells promoted cell proliferation and invasion; however, the mechanism underlying the role of CARMA3 in cancer cell invasion remained unclear.
Transitioning from Idiopathic to Explainable Autoimmune Hepatitis.
Czaja, Rochester, United States. In Dig Dis Sci, Oct 2015
Polymorphisms, including variants of SH2B3 and CARD10 genes, may affect immune reactivity and disease severity.
MicroRNA-24 upregulation inhibits proliferation, metastasis and induces apoptosis in bladder cancer cells by targeting CARMA3.
Bai et al., Haikou, China. In Int J Oncol, Oct 2015
Moreover, the low level of miR-24 was associated with increased expression of CARMA3 in bladder cancer cells.
CARMA3 Is Critical for the Initiation of Allergic Airway Inflammation.
Medoff et al., Boston, United States. In J Immunol, Aug 2015
In this study, we demonstrate that reduced levels of CARMA3 in normal human bronchial epithelial cells decreases the production of proasthmatic mediators in response to a panel of asthma-relevant GPCR ligands such as lysophosphatidic acid, adenosine triphosphate, and allergens that activate GPCRs such as Alternaria alternata and house dust mite.
CARMA3 Represses Metastasis Suppressor NME2 to Promote Lung Cancer Stemness and Metastasis.
Su et al., Taiwan. In Am J Respir Crit Care Med, Aug 2015
RATIONALE: CARD-recruited membrane-associated protein 3 (CARMA3) is a novel scaffold protein that regulates nuclear factor (NF)-κB activation; however, the underlying mechanism of CARMA3 in lung cancer stemness and metastasis remains largely unknown.
Analysis of epidermal growth factor-induced NF-κB signaling.
Lin et al., Houston, United States. In Methods Mol Biol, 2014
Recent study from our lab indicates that CARMA3, similar to the function of CARMA1 in mediating antigen receptor-mediated NF-κB activation, plays an essential role in mediating EGFR-induced NF-κB activation.
Lack of association between the CARD10 rs6000782 polymorphism and type 1 autoimmune hepatitis in a Japanese population.
Yatsuhashi et al., Ōmura, Japan. In Bmc Res Notes, 2014
More recent genome-wide association studies and replication analyses reported an association between variants of the CARD10 polymorphism rs6000782 and risk of type 1 autoimmune hepatitis (AIH).
Data for a proteomic analysis of p53-independent induction of apoptosis by bortezomib.
Ulukaya et al., Kütahya, Turkey. In Data Brief, 2014
The data here show for the first time the increased expressions of Card10, Dffb, Traf3 and Trp53bp2 in response to inhibition of the 26S proteasome.
Genetic association of SNPs near ATOH7, CARD10, CDKN2B, CDC7 and SIX1/SIX6 with the endophenotypes of primary open angle glaucoma in Indian population.
Sarangapani et al., Chennai, India. In Plos One, 2014
The current study attempts to explore the association of variations near/in genes like ATOH7, SIX1/SIX6 complex, CDKN2B, CARD10, and CDC7 with POAG and its QTs including vertical cup to disc ratio (VCDR), central corneal thickness (CCT), intra ocular pressure (IOP), and axial length (AL).
The three CARMA sisters: so different, so similar: a portrait of the three CARMA proteins and their involvement in human disorders.
Stilo et al., Italy. In J Cell Physiol, 2014
On the other hand, mutations in CARMA2 are responsible for the hereditary transmission of some inflammatory disorders of the skin, including familial psoriasis and ptiriasis; whereas expression of CARMA3 appears to be deregulated in different human tumors.
The Dishevelled, EGL-10 and pleckstrin (DEP) domain-containing protein DEPDC7 binds to CARMA2 and CARMA3 proteins, and regulates NF-κB activation.
Stilo et al., Benevento, Italy. In Plos One, 2013
Herein we identified the DEP domain-containing protein DEPDC7 as cellular binding partners of CARMA2 and CARMA3 proteins.
Epithelial growth factor receptor-activated nuclear factor κB signaling and its role in epithelial growth factor receptor-associated tumors.
Lin et al., Houston, United States. In Cancer J, 2013
Here, we discuss recent progress in EGFR-induced NF-κB pathways, including the identification of CARMA3-Bcl10-MALT1 complex and protein kinase C[Latin Small Letter Open E] as 2 essential signaling components linking EGFR to the activation of IκBα kinase.
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
Aung et al., Singapore, Singapore. In Hum Mol Genet, 2011
Polymorphisms of ATOH7, TGFBR3 and CARD10 influence the size of optic disc area.
CARMA3 is crucial for EGFR-Induced activation of NF-κB and tumor progression.
Lin et al., Houston, United States. In Cancer Res, 2011
Data show that CARMA3 and Bcl10 contributed to several characteristics of EGFR-associated malignancy, including proliferation, survival, migration, and invasion.
Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3·Bcl10·MALT1 signalosome.
Lucas et al., Ann Arbor, United States. In J Biol Chem, 2011
Thrombin-dependent NF-{kappa}B activation and monocyte/endothelial adhesion are mediated by the CARMA3.Bcl10.MALT1 signalosome
Molecular basis of lysophosphatidic acid-induced NF-κB activation.
Yang et al., Houston, United States. In Cell Signal, 2010
PKC, β-arrestin 2, CARMA3, BCL10, MALT1, TRAF6 and MEKK3 are signaling proteins that have a key role in G protein-coupled receptor (GPCR)-mediated activation of nuclear factor-κB (NF-κB) pathway in nonhematopoietic cells in response to lysophosphatidic acid (LPA) stimulation.
The CARMA3-Bcl10-MALT1 signalosome promotes angiotensin II-dependent vascular inflammation and atherogenesis.
Lucas et al., Ann Arbor, United States. In J Biol Chem, 2010
the type 1 receptor for angiotensin II utilizes the CARMA3-Bcl10-MALT1 signalosome for activation of NF-kappaB in endothelial and vascular smooth muscle cells, thereby inducing pro-inflammatory signals within the vasculature
CXCL12/SDF-1 alpha activates NF-kappaB and promotes oral cancer invasion through the Carma3/Bcl10/Malt1 complex.
Wang et al., Los Angeles, United States. In Int J Oral Sci, 2009
activation of NF-kappaB by CXCR4 occurs through Carma3/Bcl10/Malt1 (CBM) complex in OSCC. loss of components of CBM complex in HNSCC can inhibit SDF-1 alpha induced phosphorylation and degradation of IkappaBalpha.
share on facebooktweetadd +1mail to friends