Small Molecule Inhibitors of Protein Arginine Methyltransferases.
Athens, United States. In Expert Opin Investig Drugs, Feb 2016
Great efforts are seen in screening and designing potent and selective PRMT inhibitors, and a number of micromolar and submicromolar inhibitors have been obtained for key PRMT enzymes such as PRMT1, CARM1, and PRMT5.
Transcriptome profiling of bovine inner cell mass and trophectoderm derived from in vivo generated blastocysts.
Eşfahān, Iran. In Bmc Dev Biol, 2014
Moreover, a great majority of genes that were found to be misregulated following in vitro culture of bovine embryos were known genes involved in epigenetic regulation of pluripotency and cell differentiation including DNMT1, GADD45, CARM1, ELF5 HDAC8, CCNB1, KDM6A, PRDM9, CDX2, ARID3A, IL6, GADD45A, FGFR2, PPP2R2B, and SMARCA2.
CARMA: CARM1 methylation of SWI/SNF in breast cancer.
Boston, United States. In Cancer Cell, 2014
In this issue of Cancer Cell, Wang and colleagues report that CARM1, a protein arginine methyltransferase, specifically methylates BAF155/SMARCC1, a core subunit of the SWI/SNF chromatin remodeling/tumor suppressor complex.
CARM1 mediates modulation of Sox2.
Beijing, China. In Plos One, 2010
found that CARM1 facilitates Sox2-mediated transactivation and directly methylates Sox2 at arginine 113
Vitamin D: molecular mechanism of action.
Newark, United States. In Ann N Y Acad Sci, 2007
In our laboratory we have identified various factors that cooperate with the vitamin D receptor in regulating 24(OH)ase expression including C/EBP beta, SWI/SNF (complexes that remodel chromatin using the energy of ATP hydrolysis) and the methyltransferases, CARM1 and G9a.
Bile salt excretory pump: biology and pathobiology.
New York City, United States. In J Pediatr Gastroenterol Nutr, 2006
We have recently demonstrated a role for the coactivator-associated arginine methyltransferase 1 (CARM1), as a coactivator of the FXR/RXR receptor and regulator of FXR responsive genes such as BSEP.
Histone arginine methylation and its dynamic regulation.
New York City, United States. In Front Biosci, 2005
In mammals, PRMT1- and CARM1-catalyzed histone asymmetric dimethyl-arginine is involved in gene activation while PRMT5-catalyzed histone symmetric dimethyl-arginine is associated with gene repression.