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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Cardiotrophin 1

cardiotrophin-1, CT-1, CHL1
The protein encoded by this gene is a secreted cytokine that induces cardiac myocyte hypertrophy in vitro. It has been shown to bind and activate the ILST/gp130 receoptor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008] (from NCBI)
Top mentioned proteins: Interleukin-6, CAN, CT2, NMDA receptor, HAD
Papers on cardiotrophin-1
Necdin controls EGFR signaling linked to astrocyte differentiation in primary cortical progenitor cells.
Yoshikawa et al., Ōsaka, Japan. In Cell Signal, Feb 2016
In necdin-null CPCs, astrocyte differentiation induced by the gliogenic cytokine cardiotrophin-1 was significantly accelerated in the presence of EGF, and inhibition of EGFR/ERK signaling abolished the acceleration.
Predictive Value for Galectin 3 and Cardiotrophin 1 in Hemodialysis Patients.
Covic et al., Jászvásár, Romania. In Angiology, Feb 2016
The prognostic value of the new cardiac biomarkers, cardiotrophin 1 (CT-1) and galectin 3 (GAL-3), has not yet been defined in hemodialysis (HD) patients.
Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway.
Cao et al., Xi'an, China. In J Geriatr Cardiol, Nov 2015
The present study was designed to investigate the effects of cardiotrophin-1 (CT-1) on cardiomyocyte differentiation from mouse induced pluripotent stem cells (miPSCs) and the underlying mechanisms involved.
Leukemia inhibitory factor (LIF).
Babon et al., Melbourne, Australia. In Cytokine Growth Factor Rev, Oct 2015
It utilises a receptor that consists of the LIF receptor β and gp130 and this receptor complex is also used by ciliary neurotrophic growth factor (CNTF), oncostatin M, cardiotrophin1 (CT1) and cardiotrophin-like cytokine (CLC).
Cardiotrophin-1: A multifaceted cytokine.
Bustos et al., Pamplona, Spain. In Cytokine Growth Factor Rev, Oct 2015
Cardiotrophin-1 (CT-1) is a member of the gp130 family of cytokines that have pleiotropic functions on different tissues and cell types.
Searching for new mechanisms of myocardial fibrosis with diagnostic and/or therapeutic potential.
Díez et al., Maastricht, Netherlands. In Eur J Heart Fail, Aug 2015
cardiotrophin-1, galectin-3, NADPH oxidases, and neutrophil gelatinase-associated lipocalin), microRNA-induced alterations of collagen gene expression, and matricellular protein- and lysyl oxidase-mediated alterations of collagen cross-linking and deposition.
Distal 3p duplication and terminal 7q deletion associated with nuchal edema and cyclopia in a fetus and a review of the literature.
Wang et al., Taipei, Taiwan. In Taiwan J Obstet Gynecol, Jun 2015
The analysis of array comparative genomic hybridization analysis revealed a 43.68-Mb duplication of 3p26.3-3p22.1 encompassing CHL1 and CNTN4, and an 8.66-Mb deletion of 7q36.1-7q36.3
Cardiotrophin-1 is inversely associated with obesity in non-diabetic individuals.
Chang et al., Tainan City, Taiwan. In Sci Rep, 2014
Cardiotrophin-1 is known to be a key regulator of energy homeostasis, as well as glucose and lipid metabolism in vivo.
Can biomarkers help to diagnose early heart failure with preserved ejection fraction?
Tomandl et al., Brno, Czech Republic. In Dis Markers, 2014
Recently, cardiotrophin-1, soluble endoglin, ST2, growth differentiation factor 15, galectin-3, and other new laboratory markers associated with LVFP have emerged.
Efficient charge generation by relaxed charge-transfer states at organic interfaces.
Salleo et al., Stanford, United States. In Nat Mater, 2014
Here, we investigate the role of the lowest energy emissive interfacial charge-transfer state (CT1) in the charge generation process.
Everyone gets involved: fostering a high quality teaching and learning culture in the NHS.
Sansom et al., Bristol, United Kingdom. In Bmj Qual Improv Rep, 2013
23% were F1s, 14% were F2s, 24% CT1-2s.
High-risk medulloblastoma: a pediatric oncology group randomized trial of chemotherapy before or after radiation therapy (POG 9031).
Kun et al., Boston, United States. In J Clin Oncol, 2013
Five-year EFS was 66.0% in the CT1 arm and 70.0% in the RT1 arm (P = .54),
MicroRNA-10a targets CHL1 and promotes cell growth, migration and invasion in human cervical cancer cells.
Tang et al., Tianjin, China. In Cancer Lett, 2012
miR-10a expression is upregulated in cervical cancer tissues, and miR-10a promotes cell growth, migration and invasion by targeting CHL1 in human cervical cancer cells.
The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.
De Strooper et al., Leuven, Belgium. In J Biol Chem, 2012
L1 and CHL1 are cleaved by BACE1 under physiological conditions
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets.
Groop et al., Malmö, Sweden. In Cell Metab, 2012
We integrated our data to form a rank list of putative T2D genes, of which CHL1, LRFN2, RASGRP1, and PPM1K were validated in INS-1 cells to influence insulin secretion, whereas GPR120 affected apoptosis in islets.
Adhesion molecules close homolog of L1 and tenascin-C affect blood-spinal cord barrier repair.
Schachner et al., United States. In Neuroreport, 2012
This study provided evidence that the CHL1 affect the repair of the blood-spinal cord barrier repair in soinal cord injury.
Muscle contraction increases carnitine uptake via translocation of OCTN2.
Masuda et al., Kanazawa, Japan. In Biochem Biophys Res Commun, 2012
The present study showed that muscle contraction facilitated carnitine uptake in skeletal muscles, possibly via the contraction-induced translocation of its specific transporter OCTN2 to the plasma membrane.
Association study of IL-17RC, CHL1, DSCAM and CNTNAP2 genes polymorphisms with adolescent idiopathic scoliosis susceptibility in a Chinese Han population.
Qiu et al., Nanjing, China. In Stud Health Technol Inform, 2011
Overall, our study found a significant association of IL-17RC gene polymorphisms with AIS in a Chinese Han population, indicating IL-17RC gene may be as a susceptibility gene for AIS.
Cardiotrophin-1 is a key regulator of glucose and lipid metabolism.
Bustos et al., Pamplona, Spain. In Cell Metab, 2011
We conclude that CT-1 is a master regulator of fat and glucose metabolism with potential applications for treatment of obesity and insulin resistance.
CHL1 functions as a nitrate sensor in plants.
Tsay et al., Taipei, Taiwan. In Cell, 2009
CHL1 uses dual-affinity binding and a phosphorylation switch to sense a wide range of nitrate concentrations in the soil, thereby functioning as an ion sensor in higher plants.
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