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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Troponin I type 3

cardiac troponin I, cardiac troponin T, cTnI
Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: cTnT, HAD, CAN, AGE, V1a
Papers using cardiac troponin I antibodies
Growth of the developing mouse heart: An interactive qualitative and quantitative 3D atlas
Supplier
Polymenis Michael, In PLoS ONE, 2011
... overnight to a mixture of anti-IdU (mouse-monoclonal anti-BrdU; BD, 347580), anti-CldU (rat-monoclonal anti-BrdU; Serotec, OBT0030CX) and anti-cTnI (rabbit polyclonal; HyTest, 4T21/2) followed by incubation ...
Protein kinase D (PKD) activation in intact cells through a protein kinase C-dependent signal transduction pathway
Supplier
Avkiran Metin et al., In Basic Research in Cardiology, 1995
... Antibodies for PKD, pSer916 PKD, pSer744/748 PKD and pSer22/3 cTnI were from Cell Signaling Technology, PLB and pSer16 ...
Characterization of the Fc receptor for IgG on a human macrophage cell line
Supplier
Paek Se-Hwan et al., In Journal of Biomedicine and Biotechnology, 1979
... stock of cTnI-T-C complex (from human cardiac muscle tissue) and mouse monoclonal antibody specific to cTnI (Clone 19C7) were supplied by HyTest (Turku, Finland) ...
Papers on cardiac troponin I
N-terminal pro-B-type natriuretic peptide and cardiac troponin T in non-immune hydrops.
New
Park et al., Seoul, South Korea. In J Obstet Gynaecol Res, Feb 2016
AIM: We analyzed the N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponin T (cTnT) in non-immune hydrops cases, to determine whether congestive heart failure or inadequate cardiac output may be mechanisms underlying abnormal fluid collection in hydrops.
High-sensitivity cardiac troponin I at presentation in patients with suspected acute coronary syndrome: a cohort study.
New
Impact
High-STEACS investigators et al., Minneapolis, United States. In Lancet, Jan 2016
We measured plasma troponin concentrations at presentation using a high-sensitivity cardiac troponin I assay.
Cardiac biomarkers in cats.
Review
New
Luis Fuentes et al., United Kingdom. In J Vet Cardiol, Dec 2015
The evidence base for the use of cardiac biomarkers (primarily N-terminal pro-B type natriuretic peptide and cardiac troponin I) in cats is comprehensively reviewed in this article, focusing on each of six specific areas: distinguishing cardiac from non-cardiac causes of respiratory distress; measurement of cardiac biomarkers in urine and pleural fluid; identification of occult cardiomyopathy; effects of systemic disease on circulating concentrations of cardiac biomarkers; point-of-care biomarker testing, and the possible prognostic utility of cardiac biomarker measurement.
A Case of Influenza Associated Fulminant Myocarditis Successfully Treated with Intravenous Peramivir.
New
Kim et al., Seoul, South Korea. In Infect Chemother, Dec 2015
Further evaluation disclosed an increased cardiac troponin I level of 1.36 ng/mL and a depressed left ventricular ejection fraction of 30%.
Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury.
New
Mladěnka et al., Hradec Králové, Czech Republic. In Oxid Med Cell Longev, Dec 2015
However, whereas the low D-penicillamine dose decreased the release of cardiac troponin T (specific marker of myocardial injury), the high dose resulted in an increase.
Cardiotrophin-1 promotes cardiomyocyte differentiation from mouse induced pluripotent stem cells via JAK2/STAT3/Pim-1 signaling pathway.
New
Cao et al., Xi'an, China. In J Geriatr Cardiol, Nov 2015
Elevated amount of α-myosin heavy chain (α-MHC) and cardiac troponin I (cTn I) positive cells were detected by immunofluorescence staining and flow cytometry analysis in CT-1 group.
A Systematic Review of Phenotypic Features Associated With Cardiac Troponin I Mutations in Hereditary Cardiomyopathies.
Review
New
Lambrecht et al., Odense, Denmark. In Can J Cardiol, Nov 2015
METHODS: We reviewed the literature in relation to phenotypic features reported to be associated with mutations in cardiac troponin I (cTnI; TNNI3), which is a recognized sarcomeric disease gene in all 3 cardiomyopathies.
B-type natriuretic peptide as a parameter for pulmonary hypertension in children. A systematic review.
Review
New
Kraemer et al., Rotterdam, Netherlands. In Eur J Pediatr, Oct 2015
Cardiac troponin T (TnT), brain natriuretic peptide (BNP), and NT-proBNP seem the most potential.
Biomarker changes after strenuous exercise can mimic pulmonary embolism and cardiac injury--a metaanalysis of 45 studies.
Review
New
Meder et al., Heidelberg, Germany. In Clin Chem, Oct 2015
RESULTS: Across all studies cardiac troponin T (cTnT) exceeded the cutoff value (0.01 ng/mL) in 51% (95% CI, 37%-64%) of participants.
Troponin and Cardiac Events in Stable Ischemic Heart Disease and Diabetes.
New
Impact
BARI 2D Study Group et al., Rochester, United States. In N Engl J Med, Sep 2015
METHODS: We measured the cardiac troponin T concentration at baseline with a high-sensitivity assay in 2285 patients who had both type 2 diabetes and stable ischemic heart disease and were enrolled in the Bypass Angioplasty Revascularization Investigation in Type 2 Diabetes trial.
[Spontaneous coronary artery dissection treated by intravascular ultrasound-guided percutaneous coronary intervention: case report and review of the literature].
Review
New
Cavallini et al., Perugia, Italy. In G Ital Cardiol (rome), Jun 2015
We present the case of a young woman admitted with typical chest pain associated with electrocardiographic changes and elevated cardiac troponin I.
An Upgrade on the Rabbit Model of Anthracycline-Induced Cardiomyopathy: Shorter Protocol, Reduced Mortality, and Higher Incidence of Overt Dilated Cardiomyopathy.
Moraleda et al., Murcia, Spain. In Biomed Res Int, 2014
Results of blood tests, cardiac troponin I, echocardiography, and histopathology were analysed.
Fibrinolysis for patients with intermediate-risk pulmonary embolism.
Impact
PEITHO Investigators et al., Aş Şanamayn, Syria. In N Engl J Med, 2014
Eligible patients had right ventricular dysfunction on echocardiography or computed tomography, as well as myocardial injury as indicated by a positive test for cardiac troponin I or troponin T. The primary outcome was death or hemodynamic decompensation (or collapse) within 7 days after randomization.
Cardioprotective and prognostic effects of remote ischaemic preconditioning in patients undergoing coronary artery bypass surgery: a single-centre randomised, double-blind, controlled trial.
Impact
Heusch et al., Essen, Germany. In Lancet, 2013
The primary endpoint was myocardial injury, as reflected by the geometric mean area under the curve (AUC) for perioperative concentrations of cardiac troponin I (cTnI) in serum in the first 72 h after CABG.
Alanine or aspartic acid substitutions at serine23/24 of cardiac troponin I decrease thin filament activation, with no effect on crossbridge detachment kinetics.
GeneRIF
Chandra et al., Pullman, United States. In Arch Biochem Biophys, 2012
the functional impact of cardiac troponin I (cTnI) phosphorylation by protein kinase A
Delta changes for optimizing clinical specificity and 60-day risk of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome utilizing the ADVIA Centaur TnI-Ultra assay.
GeneRIF
Murakami et al., Minneapolis, United States. In Clin Biochem, 2012
Data indicate that utilizing delta cardiac troponin I (cTnI) values improves clinical specificity, diagnostic accuracy and risk assessment in patients presenting with symptoms of acute coronary syndrome.
AMP-activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA-dependent function.
GeneRIF
Biesiadecki et al., Columbus, United States. In J Biol Chem, 2012
the blunting effect of cTnI Ser-150 phosphorylation cross-talk can uncouple the effects of myofilament PKA-dependent phosphorylation from beta-adrenergic signaling as a novel thin filament contractile regulatory signaling mechanism.
Systematic discovery of structural elements governing stability of mammalian messenger RNAs.
Impact
Tavazoie et al., Princeton, United States. In Nature, 2012
There are many documented instances where the presence of a structural regulatory element dictates alternative splicing patterns (for example, human cardiac troponin T) or affects other aspects of RNA biology.
pH-responsive titratable inotropic performance of histidine-modified cardiac troponin I.
GeneRIF
Metzger et al., Minneapolis, United States. In Biophys J, 2012
differential histidine ionization may be necessary for cTnI A164H to act as a molecular sensor capable of modulating sarcomere performance in response to changes in the cytosolic milieu
Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates.
GeneRIF
Davis et al., Columbus, United States. In Plos One, 2011
The disease-related protein modifications alter Ca(2+) binding by influencing both the association and dissociation rates of thin filament Ca(2+) exchange.
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