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Caspase recruitment domain family, member 6

CARD6, Caspase recruitment domain protein 6
This gene encodes a protein that contains a caspase recruitment domain (CARD), an antiparallel six-helical bundle that mediates homotypic protein-protein interactions. The encoded protein is a microtubule-associated protein that has been shown to interact with receptor-interacting protein kinases and positively modulate signal transduction pathways converging on activation of the inducible transcription factor NF-kB. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PrP, NF-kappaB, HAD, BCL10, NOD
Papers on CARD6
Curcumin alters gene expression-associated DNA damage, cell cycle, cell survival and cell migration and invasion in NCI-H460 human lung cancer cells in vitro.
Chung et al., Yilan, China. In Oncol Rep, Oct 2015
Specifically, the up‑ and downregulated genes included CCNE2, associated with DNA damage; ID3, associated with cell survival and 146 genes with a >2- to 3-fold change including the TP53INP1 gene, associated with DNA damage; CDC6, CDCA5, TAKMIP2, CDK14, CDK5, CDCA76, CDC25A, CDC5L and SKP2, associated with cell cycle; the CARD6, ID1 and ID2 genes, associated with cell survival and the BRMS1L, associated with cell migration and invasion.
cDNA microarray analysis of the effect of cantharidin on DNA damage, cell cycle and apoptosis-associated gene expression in NCI-H460 human lung cancer cells in vitro.
Chung et al., Taipei, Taiwan. In Mol Med Report, Jul 2015
Furthermore, apoptosis-associated genes were differentially expressed, including CARD6, which was upregulated 3.54-fold.
Caspase recruitment domain 6 protects against cardiac hypertrophy in response to pressure overload.
Chen et al., Wuhan, China. In Hypertension, 2014
Caspase recruitment domain 6 (CARD6), a crucial member of the CARD family, was initially shown to be involved in the immune system and oncogenesis.
Expression profile of apoptosis-related genes potentially explains early recurrence after definitive chemoradiation in esophageal squamous cell carcinoma.
Lu et al., Chengdu, China. In Tumour Biol, 2014
Quantitative real-time polymerase chain reaction showed upregulation of BCLAF1 and downregulation of BAG4, CARD6, IGF1R, and TNF in the tissues of case patients, as compared with controls.
Comprehensive whole-genome sequencing of an early-stage primary myelofibrosis patient defines low mutational burden and non-recurrent candidate genes.
Gotlib et al., In Haematologica, 2013
Interfacing of whole-genome DNA sequence data with RNA expression data identified three somatic mutations of potential functional significance: i) a nonsense mutation in CARD6, implicated in modulation of NF-kappaB activation; ii) a 19-base pair deletion involving a potential regulatory region in the 5'-untranslated region of BRD2, implicated in transcriptional regulation and cell cycle control; and iii) a non-synonymous point mutation in KIAA0355, an uncharacterized protein.
Expression of CARD6, an NF-kappaB activator, in gastric, colorectal and oesophageal cancers.
Lee et al., Seoul, South Korea. In Pathology, 2010
The increased expression of CARD6 in esophageal squamous cell carcinoma,gastric and colorectal adenocarcinoma suggested that neoexpression of CARD6 might be related to activation of NF-kappaB pathway.
Structure and expression pattern of teleost caspase recruitment domain (CARD) containing proteins that are potentially involved in NF-kappaB signalling.
Nie et al., Wuhan, China. In Dev Comp Immunol, 2010
Phylogenetic analysis showed that the orthologs to mammalian RIPK2, NOD1, PYCARD, CARD9, CARD10, CARD11, CARD14, NOD2 and BCL10 were evident in teleost fish, but clear orthologs to mammalian CARD6 and CARD8 were not found in teleost fish.
Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation.
Feuerhake et al., Heidelberg, Germany. In J Neurosurg, 2009
Moreover, 5 genes (BDNF, CARD6, FOSL1, HSPA9B, and MYC) involved in antiapoptotic pathways were unexpectedly found to be associated with sensitivity.
CARD6 is interferon inducible but not involved in nucleotide-binding oligomerization domain protein signaling leading to NF-kappaB activation.
Mak et al., Toronto, Canada. In Mol Cell Biol, 2008
We have previously reported the cloning and characterization of CARD6, a caspase recruitment domain (CARD)-containing protein that is structurally related to the interferon (IFN)-inducible GTPases.
Effects of organ culture and Optisol-GS storage on structural integrity, phenotypes, and apoptosis in cultured corneal epithelium.
Lyberg et al., Oslo, Norway. In Invest Ophthalmol Vis Sci, 2007
The expression of the antiapoptotic gene BCL2 was prominently upregulated in storage at 23 degrees C and 5 degrees C. Downregulation of BCL2A1, BIRC1, and TNF and upregulation of CARD6 in 23 degrees C and 5 degrees C storage conditions suggests a reduction in nuclear factor-kappaB activity.
CARD tricks: controlling the interactions of CARD6 with RICK and microtubules.
Mak et al., Toronto, Canada. In Cell Cycle, 2006
review of the regulation of interactions of CARD6 with RICK and microtubules [review]
Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-kappaB activation.
Mak et al., Toronto, Canada. In Proc Natl Acad Sci U S A, 2006
CARD6 is a regulator of NF-kappaB activation that modulates the functions of RICK protein
CARD6 is a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways.
Reed et al., Los Angeles, United States. In J Biol Chem, 2003
identification as a modulator of NF-kappa B activation by Nod1- and Cardiak-mediated pathways
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