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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Carboxypeptidase M

carboxypeptidase M, carboxypeptidase M is
The protein encoded by this gene is a membrane-bound arginine/lysine carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: carboxypeptidase, ACID, CAN, HAD, Angiotensin II
Papers on carboxypeptidase M
Directed Induction of Functional Multi-ciliated Cells in Proximal Airway Epithelial Spheroids from Human Pluripotent Stem Cells.
New
Mishima et al., Kyoto, Japan. In Stem Cell Reports, Feb 2016
Using carboxypeptidase M (CPM) as a surface marker of NKX2-1(+)-ventralized anterior foregut endoderm cells (VAFECs), we report a three-dimensional differentiation protocol for generating proximal airway epithelial progenitor cell spheroids from CPM(+) VAFECs.
Genomic landscape of liposarcoma.
New
Koeffler et al., Singapore, Singapore. In Oncotarget, Jan 2016
Carboxypeptidase M (CPM), recurrently amplified gene in well-differentiated/de-differentiated LPS was noted as a putative oncogene involved in the EGFR pathway.
CPM Is a Useful Cell Surface Marker to Isolate Expandable Bi-Potential Liver Progenitor Cells Derived from Human iPS Cells.
New
Miyajima et al., Tokyo, Japan. In Stem Cell Reports, Nov 2015
We have found that carboxypeptidase M (CPM) is highly expressed in embryonic LPCs, hepatoblasts, while its expression is decreased along with hepatic maturation.
Pharmacological Activities and Hydrolysis by Peptidases of [Phospho-Ser(6)]-Bradykinin (pS(6)-BK).
New
Juliano et al., São Paulo, Brazil. In Biochem Pharmacol, Oct 2015
[pS(6)]-Bk was more resistant than Bk to kininase digestion performed with angiotensin converting enzyme, neprilysin, thimet oligopeptidase, aminopeptidase P and carboxypeptidase M. (1)H-NMR experiments indicated that [pS(6)]-Bk has lower flexibility, with the pS(6)-P(7) bond restricted to the trans conformation, and can explain [pS(6)]-Bk resistance to hydrolysis.
Proteomics of the human endometrial glandular epithelium and stroma from the proliferative and secretory phases of the menstrual cycle.
New
Risinger et al., Harbin, China. In Biol Reprod, Apr 2015
Several proteins were chosen for validation by immunohistochemistry in an independent set of uterine tissues, including carboxypeptidase M, tenascin C, neprilysin, and ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3).
A genome-wide association study identifies susceptibility loci of silica-related pneumoconiosis in Han Chinese.
Shen et al., Wuhan, China. In Hum Mol Genet, 2015
In addition, the risk allele T of rs73329476 was significantly associated with lower mRNA expression levels of carboxypeptidase M (CPM) in total cellular RNA from whole blood of 156 healthy individuals (P = 0.0252).
Generation of alveolar epithelial spheroids via isolated progenitor cells from human pluripotent stem cells.
Mishima et al., Kyoto, Japan. In Stem Cell Reports, 2014
Based on a study of the stepwise induction of alveolar epithelial cells (AECs), we identified carboxypeptidase M (CPM) as a surface marker of NKX2-1(+) "ventralized" anterior foregut endoderm cells (VAFECs) in vitro and in fetal human and murine lungs.
Analysis of differentially expressed genes between rheumatoid arthritis and osteoarthritis based on the gene co-expression network.
Fu et al., Shanghai, China. In Mol Med Report, 2014
The top 20 disease-associated genes were identified, including proteoglycan 4, inhibin β B, carboxypeptidase M, alcohol dehydrogenase 1C and integrin β2.
Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor.
Skidgel et al., In J Biol Chem, 2013
We previously showed that the protein-protein interaction of carboxypeptidase M (CPM) and kinin B1 receptor (B1R) enhances B1R signaling in two ways; 1) kinin binding to CPM causes a conformational activation of the B1R, and 2) CPM-generated des-Arg-kinin agonist is efficiently delivered to the B1R.
Phase 2 trial of single-agent everolimus in chemotherapy-naive patients with castration-resistant prostate cancer (SAKK 08/08).
Swiss Group for Clinical Cancer Research (SAKK) et al., Sankt Gallen, Switzerland. In Eur Urol, 2013
Higher serum levels of carboxypeptidase M and apolipoprotein B were predictive for reaching the primary end point.
Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output.
Review
Skidgel et al., Chicago, United States. In Biol Chem, 2013
Here, we review the evidence for a critical role of membrane-bound CPM in facilitating B1R signaling by its ability to directly activate the receptor via conformational crosstalk as well as generate its specific agonist.
The potential of carboxypeptidase M as a therapeutic target in cancer.
Review
Lambeir et al., Antwerp, Belgium. In Expert Opin Ther Targets, 2013
INTRODUCTION: In the recent literature, carboxypeptidase M (CPM) emerged as a potential cancer biomarker.
Carboxypeptidase M in apoptosis, adipogenesis and cancer.
Review
Lambeir et al., Antwerp, Belgium. In Clin Chim Acta, 2013
This review covers carboxypeptidase M (CPM) research that appeared in the literature since 2009.
Carboxypeptidase-M is regulated by lipids and CSFs in macrophages and dendritic cells and expressed selectively in tissue granulomas and foam cells.
GeneRIF
Dezso et al., Debrecen, Hungary. In Lab Invest, 2012
novel marker and cellular player in lipid uptake and/or metabolism of activated macrophages by promoting foam cell formation
The ins and outs of hematopoietic stem cells: studies to improve transplantation outcomes.
Review
Janowska-Wieczorek et al., Edmonton, Canada. In Stem Cell Rev, 2011
Particularly, we will discuss our studies on stromal cell-derived factor-1 and its interaction with its receptor CXCR4, proteases (matrix metalloproteinases and carboxypeptidase M), complement proteins (C1q, C3a, C5a, membrane attack complex), sphingosine-1-phosphate, and pharmacologic agents such as the histone deacetylase inhibitor valproic acid and hyaluronic acid.
Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signaling.
GeneRIF
Skidgel et al., Chicago, United States. In J Biol Chem, 2011
CPM and B1Rs on cell membranes form a critical complex that potentiates B1R signaling.
Infection-associated vasculopathy in experimental chagas disease pathogenic roles of endothelin and kinin pathways.
Review
Andrade et al., Rio de Janeiro, Brazil. In Adv Parasitol, 2010
Tightly regulated by angiotensin-converting enzyme, the intact kinins (BK(2)R agonists) may be processed by carboxypeptidase M/N, generating [des-Arg]-kinins, which activates BK(1)R, a subtype of GPCR that is upregulated by cardiovascular cells during inflammation.
Carboxypeptidase M: a biomarker for the discrimination of well-differentiated liposarcoma from lipoma.
GeneRIF
Oliveira et al., Rochester, United States. In Mod Pathol, 2009
CPM amplification could be used as an alternative diagnostic tool for the diagnosis of well-differentiated liposarcoma/atypical lipomatous tumors.
Carboxypeptidase M expressed by human bone marrow cells cleaves the C-terminal lysine of stromal cell-derived factor-1alpha: another player in hematopoietic stem/progenitor cell mobilization?
GeneRIF
Janowska-Wieczorek et al., Edmonton, Canada. In Stem Cells, 2008
Cleavage of the C-terminal lysine residue of SDF-1alpha by CPM leads to attenuated chemotactic responses.
Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists.
GeneRIF
Skidgel et al., Chicago, United States. In J Biol Chem, 2008
Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists
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