Detoxification of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes: A theoretical investigation.
Lanzhou, China. In J Inorg Biochem, Jan 2016
Two types of detoxification routes, N-demethylation to form 4-phenyl-1,2,3,6-tetrahydropyridine (PTP) and aromatic hydroxylation to generate 4-(4'-hydroxyphenyl)-1-methyl-1,2,3,6-tetrahydropyridine (MPTP-OH), for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mediated by Compound I (Cpd I) of cytochrome P450 are investigated theoretically using hybrid density functional calculations.
Comparative Genome of GK and Wistar Rats Reveals Genetic Basis of Type 2 Diabetes.
Shanghai, China. In Plos One, 2014
Finally we have identified 15 genetic mutant genes which include seven known T2D related genes (Tnfrsf1b, Scg5, Fgb, Sell, Dpp4, Icam1, and Pkd2l1) and eight high-confidence new candidate genes (Ldlr, Ccl2, Erbb3, Akr1b1, Pik3c2a, Cd5, Eef2k, and Cpd).
Homer proteins in Ca²⁺ entry.
Cáceres, Spain. In Iubmb Life, 2013
The Homer family of proteins consists of three adaptor proteins, Homer1, Homer2 and Homer3, each with various isoforms.
Cdc25A protein phosphatase: a therapeutic target for liver cancer therapies.
Philadelphia, United States. In Anticancer Agents Med Chem, 2008
Inhibition of Cdc25A activity by a K vitamin analog Compound 5 (Cpd 5) can induce a strong and prolonged activation of epidermal growth factor receptor (EGFR)-MAPK pathway, which leads to suppression of transcription factors CREB and c-Myc, resulting in decreased expression of Cdc25A and cyclin D1 levels.