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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Carboxypeptidase D

carboxypeptidase D, Cpd, gp180, Homer2
The metallocarboxypeptidase family of enzymes is divided into 2 subfamilies based on sequence similarities. The pancreatic carboxypeptidase-like and the regulatory B-type carboxypeptidase subfamilies. Carboxypeptidase D has been identified as a regulatory B-type carboxypeptidase. CPD is a homolog of duck gp180, a hepatitis B virus-binding protein. Transcript variants utilizing alternative polyadenylation signals exist for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: carboxypeptidase, CAN, ACID, CD45, V1a
Papers on carboxypeptidase D
The role of the proximal cysteine hydrogen bonding interaction in cytochrome P450 2B4 studied by cryoreduction/EPR/ENDOR spectroscopy.
New
Waskell et al., In Biochemistry, Feb 2016
(iv) In both WT and mutant enzyme, this decay shows a significant solvent kinetic isotope effect, indicating that the decay reflects a proton-assisted conversion to Compound I (Cpd I).
Functional Regulation of PI3K-Associated Signaling in the Accumbens by Binge Alcohol Drinking in Male but not Female Mice.
New
Finn et al., Portland, United States. In Neuropharmacology, Feb 2016
Expression of genes encoding mGlu1, mGlu5, the NR2A subunit of the NMDA receptor, and Homer2 were all decreased by binge alcohol consumption in males, while females were relatively resistant (only phosphoinositide-dependent protein kinase 1 was decreased).
Detoxification of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by cytochrome P450 enzymes: A theoretical investigation.
New
Zhang et al., Lanzhou, China. In J Inorg Biochem, Jan 2016
Two types of detoxification routes, N-demethylation to form 4-phenyl-1,2,3,6-tetrahydropyridine (PTP) and aromatic hydroxylation to generate 4-(4'-hydroxyphenyl)-1-methyl-1,2,3,6-tetrahydropyridine (MPTP-OH), for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mediated by Compound I (Cpd I) of cytochrome P450 are investigated theoretically using hybrid density functional calculations.
Altered NMDA receptor function in primary cultures of hippocampal neurons from mice lacking the Homer2 gene.
New
Woodward et al., Baltimore, United States. In Synapse, Jan 2016
The postsynaptic scaffolding protein Homer2 can regulate the cell surface expression of NMDA receptors in vivo, and mice with a null mutation of the Homer2 gene exhibit an alcohol-avoiding and -intolerant phenotype that is accompanied by a lack of ethanol-induced glutamate sensitization.
To rebound or dissociate? This is the mechanistic question in C-H hydroxylation by heme and nonheme metal-oxo complexes.
New
Impact
Nam et al., Seoul, South Korea. In Chem Soc Rev, Jan 2016
Hydroxylation reactions of alkane substrates effected by the reactive compound I (Cpd I) species of cytochrome P450 enzymes are good examples.
Homer2 within the nucleus accumbens core bidirectionally regulates alcohol intake by both P and Wistar rats.
New
Szumlinski et al., Santa Barbara, United States. In Alcohol, Sep 2015
In murine models of alcoholism, the glutamate receptor scaffolding protein Homer2 bidirectionally regulates alcohol intake.
From DCPD to NTCP: The long journey towards identifying a functional hepatitis B virus receptor.
Review
New
Tong et al., Providence, United States. In Clin Mol Hepatol, Sep 2015
Previous studies with duck hepatitis B virus (DHBV) identified duck carboxypeptidase D (dCPD) as a host specific binding partner for full-length large envelope protein, and p120 as a binding partner for several truncated versions of the large envelope protein.
F429 Regulation of Tunnels in Cytochrome P450 2B4: A Top Down Study of Multiple Molecular Dynamics Simulations.
Zazza et al., Pisa, Italy. In Plos One, 2014
This is the case of the F429H mutant of the cytochrome P450 (CYP) 2B4 enzyme where the substitution, on the proximal surface of the active site, of a conserved phenylalanine 429 residue with histidine seems to hamper the formation of the active species, Compound I (porphyrin cation radical-Fe(IV) = O, Cpd I) from the ferric hydroperoxo (Fe(III)OOH-, Cpd 0) precursor.
Comparative Genome of GK and Wistar Rats Reveals Genetic Basis of Type 2 Diabetes.
Li et al., Shanghai, China. In Plos One, 2014
Finally we have identified 15 genetic mutant genes which include seven known T2D related genes (Tnfrsf1b, Scg5, Fgb, Sell, Dpp4, Icam1, and Pkd2l1) and eight high-confidence new candidate genes (Ldlr, Ccl2, Erbb3, Akr1b1, Pik3c2a, Cd5, Eef2k, and Cpd).
Homer proteins in Ca²⁺ entry.
Review
Rosado et al., Cáceres, Spain. In Iubmb Life, 2013
The Homer family of proteins consists of three adaptor proteins, Homer1, Homer2 and Homer3, each with various isoforms.
Differential regulation and localization of carboxypeptidase D and carboxypeptidase E in human and mouse β-cells.
GeneRIF
Johnson et al., Vancouver, Canada. In Islets, 2011
Either high glucose or insulin (with low glucose) up-regulates beta-cell CPD (but not CPE).
Spectroscopic characterization of cytochrome P450 Compound I.
Review
Schünemann et al., Berlin, Germany. In Arch Biochem Biophys, 2011
The cytochrome P450 protein-bound porphyrin complex with the iron-coordinated active oxygen atom as Fe(IV)O is called Compound I (Cpd I).
Trends in Aromatic Oxidation Reactions Catalyzed by Cytochrome P450 Enzymes: A Valence Bond Modeling.
Chen et al., Jerusalem, Israel. In J Chem Theory Comput, 2011
The mixed density functional theory (DFT) and valence bond study described herein focuses on the activation of 17 benzene derivatives by the active species of Cytochrome P450, so-called Compound I (Cpd I), as well as by the methoxy radical, as a potentially simple model of Cpd I (Jones, J. P.; Mysinger, M.; Korzekwa, K. R. Drug Metab.
Accumbens Homer2-mediated signaling: a factor contributing to mouse strain differences in alcohol drinking?
GeneRIF
Szumlinski et al., Santa Barbara, United States. In Genes Brain Behav, 2011
These data support the over-arching hypothesis that augmented accumbens Homer2-mediated glutamate signaling may be an endophenotype related to genetic variance in alcohol consumption
Cdc25A protein phosphatase: a therapeutic target for liver cancer therapies.
Review
Carr et al., Philadelphia, United States. In Anticancer Agents Med Chem, 2008
Inhibition of Cdc25A activity by a K vitamin analog Compound 5 (Cpd 5) can induce a strong and prolonged activation of epidermal growth factor receptor (EGFR)-MAPK pathway, which leads to suppression of transcription factors CREB and c-Myc, resulting in decreased expression of Cdc25A and cyclin D1 levels.
Prolactin and estrogen up-regulate carboxypeptidase-d to promote nitric oxide production and survival of mcf-7 breast cancer cells.
GeneRIF
Too et al., Halifax, Canada. In Endocrinology, 2008
prolactin or E2 up-regulated CPD mRNA and protein expression in MCF-7 breast cancer cells promoting their survival
Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production.
GeneRIF
Efthimiopoulos et al., Athens, Greece. In Neurobiol Dis, 2008
Homer2 and Homer3 proteins interact specifically with amyloid precursor protein (APP) by inhibiting APP processing and reducing secretion of Abeta peptides.
NFAT binding and regulation of T cell activation by the cytoplasmic scaffolding Homer proteins.
Impact
GeneRIF
Worley et al., Baltimore, United States. In Science, 2008
study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin
Homer proteins in Ca2+ signaling by excitable and non-excitable cells.
Review
Muallem et al., Baltimore, United States. In Cell Calcium, 2007
Homer2 increases the GAP activity of RGS proteins and PLCbeta that accelerate the GTPase activity of Galpha subunits.
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