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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Carbonyl reductase 1

carbonyl reductase
Top mentioned proteins: ACID, HAD, CAN, fibrillin-1, V1a
Papers on carbonyl reductase
Towards the computational design and engineering of enzyme enantioselectivity: A case study by a carbonyl reductase from Gluconobacter oxydans.
New
Wei et al., Shanghai, China. In J Biotechnol, Feb 2016
In our previous work, a NAD(H)-dependent carbonyl reductase (GoCR) was identified from Gluconobacter oxydans, which showed moderate to high enantiospecificity for the reduction of different kinds of prochiral ketones.
Gene therapy for ovarian cancer using carbonyl reductase 1 DNA with a polyamidoamine dendrimer in mouse models.
New
Mizunuma et al., Hirosaki, Japan. In Cancer Gene Ther, Jan 2016
Ovarian cancer (OC) in which carbonyl reductase 1 (CBR1) is highly expressed has good prognosis.
Rapid asymmetric reduction of ethyl 4-chloro-3-oxobutanoate using a thermostabilized mutant of ketoreductase ChKRED20.
New
Wu et al., Chengdu, China. In Appl Microbiol Biotechnol, Jan 2016
The carbonyl reductase ChKRED20 from Chryseobacterium sp.
Inhibitory effect of carbonyl reductase 1 on ovarian cancer growth via tumor necrosis factor receptor signaling.
New
Mizunuma et al., Hirosaki, Japan. In Int J Oncol, Dec 2015
We investigated the mechanisms of the inhibitory effect of carbonyl reductase 1 (CR1) on ovarian cancer growth mediated by the activation of the tumor necrotic factor receptor (TNFR) pathway.
CYP3A4 activity and haloperidol effects in alcohol addicts.
New
Matis et al., Moscow, Russia. In Int J Risk Saf Med, Dec 2015
Cytosolic carbonyl reductase reduces haloperidol to reduced form, which has 10-20% of the activity of the parent molecule.
The modulation of carbonyl reductase 1 by polyphenols.
New
Matoušková et al., Praha, Czech Republic. In Drug Metab Rev, Nov 2015
Carbonyl reductase 1 (CBR1), an enzyme belonging to the short-chain dehydrogenases/reductases family, has been detected in all human tissues.
Activity prediction of substrates in NADH-dependent carbonyl reductase by docking requires catalytic constraints and charge parameterization of catalytic zinc environment.
New
Bocola et al., Aachen, Germany. In J Comput Aided Mol Des, Nov 2015
In order to develop a predictive substrate docking protocol, we have performed molecular docking studies of diketone substrates using the catalytic state of carbonyl reductase 2 from Candida parapsilosis (CPCR2).
Highly Efficient Synthesis of Optically Pure (S)-1-phenyl-1,2-ethanediol by a Self-Sufficient Whole Cell Biocatalyst.
New
Zhu et al., Tianjin, China. In Chemistryopen, Aug 2015
In this study, it has been found that asymmetric reduction of a series of α-hydroxy aromatic ketones and 1-hydroxy-2-pentanone, catalyzed by Candida magnolia carbonyl reductase (CMCR) with glucose dehydrogenase (GDH) from Bacillus subtilis for cofactor regeneration, afforded 1-aryl-1,2-ethanediols and pentane-1,2-diol, respectively, in up to 99 % ee.
11β-Hydroxysteroid dehydrogenase 1: Regeneration of active glucocorticoids is only part of the story.
Review
New
Klusonova et al., Basel, Switzerland. In J Steroid Biochem Mol Biol, Jul 2015
Besides its important role in the fine-tuning of glucocorticoid action, 11β-HSD1 is a multi-functional carbonyl reductase converting several 11- and 7-oxosterols into the respective 7-hydroxylated forms.
Chemical and enzymatic approaches to the synthesis of optically pure ethyl (R)-4-cyano-3-hydroxybutanoate.
Review
Zheng et al., In Appl Microbiol Biotechnol, 2014
The emphasis is focused mainly on the synthetic routes using biocatalysts, such as halohydrin dehalogenase, nitrilase, carbonyl reductase, and lipase.
Antioxidants: friends or foe in prevention or treatment of cancer: the debate of the century.
Review
Abdollahi et al., Tehrān, Iran. In Toxicol Appl Pharmacol, 2013
Furthermore, some anti-cancer agents like piperlongumine bind to the active sites of several key cellular antioxidants including glutathione S transferase and carbonyl reductase 1 only in the cancer cells.
Anthracycline-related cardiomyopathy after childhood cancer: role of polymorphisms in carbonyl reductase genes--a report from the Children's Oncology Group.
Impact
Bhatia et al., Buffalo, United States. In J Clin Oncol, 2012
Polymorphisms in CBR1 and CBR3 influence synthesis of these metabolites.
Tetrabenazine for the treatment of chorea and other hyperkinetic movement disorders.
Review
Clarence-Smith et al., Houston, United States. In Expert Rev Neurother, 2011
TBZ is rapidly metabolized in the liver by carbonyl reductase to stereoisomers of hydrotetrabenazine, some of which are potent inhibitors of vesicular monoamine transporter type 2. Initially developed in the 1950s for schizophrenia, since the 1970s several publications have reported on the efficacy of TBZ in the treatment of various hyperkinetic movement disorders.
Pharmacogenetics of genes across the doxorubicin pathway.
Review
Boddy et al., Newcastle upon Tyne, United Kingdom. In Expert Opin Drug Metab Toxicol, 2011
Similar associations have been described for SNPs in the carbonyl reductase (CRB1 and CRB3) genes.
Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology.
Review
Impact
Oppermann, Oxford, United Kingdom. In Annu Rev Pharmacol Toxicol, 2006
These reductases often show broad and overlapping substrate specificities and some well-characterized members, e.g., carbonyl reductase (CBR1) or NADPH-quinone reductase (NQO1) have protective roles toward xenobiotic carbonyls and quinones because metabolic reduction leads to less toxic products, which can be further metabolized and excreted.
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