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Carbonic anhydrase I

carbonic anhydrase
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA1 is closely linked to CA2 and CA3 genes on chromosome 8, and it encodes a cytosolic protein which is found at the highest level in erythrocytes. Variants of this gene have been described in some populations. Multiple alternatively spliced variants, encoding the same protein, have been identified. Transcript variants of CA1 utilizing alternative polyA_sites have been described in literature. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: CAN, ACID, HAD, carbonic anhydrase IX, V1a
Papers using carbonic anhydrase antibodies
Expression of Na+/HCO3− co-transporter proteins (NBCs) in rat and human skeletal muscle.
Wenner Peter, In PLoS ONE, 2003
... Constructs, oocytes, and injection of cRNA and carbonic anhydraseThe CAI-cDNA (CAI-WT) was purchased from OriGene Technologies (Rockville, USA) ...
Papers on carbonic anhydrase
A minimal molecular toolkit for mineral deposition? Biochemistry and proteomics of the test matrix of adult specimens of the sea urchin Paracentrotus lividus.
Marin et al., Palermo, Italy. In J Proteomics, Feb 2016
We characterized them by 1- and 2D-electrophoreses, ELISA and immunoblotting, and using liquid chromatography coupled with Mass Spectrometry (nanoLC-MS/MS), we identified two metalloenzymes (carbonic anhydrase and MMP), a set of MSP130 family members, several C-type lectins (SM29, SM41, PM27) and cytoskeletal proteins.
Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.
Capasso et al., Napoli, Italy. In Bioorg Med Chem, Feb 2016
UNASSIGNED: We have cloned, purified and characterized the γ-carbonic anhydrase (CA, EC
Involvement of bradykinin B2 and muscarinic receptors in the prolonged diuretic and antihypertensive properties of Echinodorus grandiflorus (Cham. & Schltdl.) Micheli.
Gasparotto Junior et al., Umuarama, Brazil. In Phytomedicine, Jan 2016
In addition, activities of erythrocytary carbonic anhydrase and renal Na+/K+/ATPase were evaluated in vitro.
Making the diagnosis of Sjögren's syndrome in patients with dry eye.
Milner et al., Westerville, United States. In Clin Ophthalmol, Dec 2015
Recently, newer biomarkers have been identified, including autoantibodies to salivary gland protein-1, parotid secretory protein, and carbonic anhydrase VI, and may allow for earlier diagnosis of SS.
Hypoxia-Associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy.
Schmidberger et al., Mainz, Germany. In Adv Exp Med Biol, Dec 2015
Our study evaluated the role of the hypoxia-inducible (HIF)-1 target gene carbonic anhydrase (CA) IX in the prediction of the response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer (stages II and III).
MiT Family Translocation-Associated Renal Cell Carcinoma: A Contemporary Update With Emphasis on Morphologic, Immunophenotypic, and Molecular Mimics.
Mehra et al., Ann Arbor, United States. In Arch Pathol Lab Med, Oct 2015
Directed ancillary testing is an essential aspect to the workup of t-RCC cases and may include a panel of immunohistochemical stains, such as PAX8, pancytokeratins, epithelial membrane antigen, carbonic anhydrase IX, HMB-45, and Melan-A.
[Treatment of idiopathic intracranial hypertension by endovascular improvement of venous drainage of the brain].
Henkes et al., Stuttgart, Germany. In Ophthalmologe, Oct 2015
Most patients with IIH respond to weight reduction, repeated lumbar punctures and carbonic anhydrase inhibitors, such as acetazolamide and topiramate to reduce cerebrospinal fluid (CSF) production.
Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation.
Scheuermann et al., Zürich, Switzerland. In Nat Chem, Mar 2015
Using this approach we report the discovery of a low micromolar binder to alpha-1-acid glycoprotein and the affinity maturation of a ligand to carbonic anhydrase IX, an established marker of renal cell carcinoma.
Identification of a Potential Target of Capsaicin by Computational Target Fishing.
Chen et al., Lishui, China. In Evid Based Complement Alternat Med, 2014
Carbonic anhydrase 2 was identified as the main disease-related target, with the pharmacophore model matching well with the molecular features of capsaicin.
Interventions for central serous chorioretinopathy: a network meta-analysis.
Gehlbach et al., Baltimore, United States. In Cochrane Database Syst Rev, 2014
A substantial proportion of the trials were not masked.The studies considered a variety of treatments: anti-VEGF (ranibizumab, bevacizumab), PDT (full-dose, half-dose, 30%, low-fluence), laser treatment (argon, krypton and micropulse laser), beta-blockers, carbonic anhydrase inhibitors, Helicobactor pylori treatment, and nutritional supplements (Icaps, lutein); there were only one or two trials contributing data for each comparison.
Molecular and immunologic markers of kidney cancer-potential applications in predictive, preventive and personalized medicine.
Gratchev et al., Mannheim, Germany. In Epma J, 2014
The most common molecular markers of kidney cancer include mutations and epigenetic inactivation of von Hippel-Lindau (VHL) gene, genes of vascular endothelial growth factor (VEGF) pathway, and carbonic anhydrase IX (CIAX).
Carbonic anhydrases, EPF2 and a novel protease mediate CO2 control of stomatal development.
Schroeder et al., San Diego, United States. In Nature, 2014
Our results identify mechanisms and genes that function in the repression of stomatal development in leaves during atmospheric CO2 elevation, including the carbonic-anhydrase-encoding genes CA1 and CA4 and the secreted protease CRSP, which cleaves the pro-peptide EPF2, in turn repressing stomatal development.
Stimuli responsive systems constructed using cucurbit[n]uril-type molecular containers.
Isaacs, College Park, United States. In Acc Chem Res, 2014
We also used the high affinity and selectivity of CB[7] toward its guests to outcompete an enzyme (bovine carbonic anhydrase) for a two-faced inhibitor, which allowed stimuli responsive regulation of enzymatic activity.
Biogenesis of a bacterial organelle: the carboxysome assembly pathway.
Kerfeld et al., Berkeley, United States. In Cell, 2013
It is composed of thousands of subunits including hexameric and pentameric proteins that form a shell to encapsulate the enzymes ribulose 1,5-bisphosphate carboxylase/oxygenase and carbonic anhydrase.
Root effect hemoglobin may have evolved to enhance general tissue oxygen delivery.
Brauner et al., Vancouver, Canada. In Science, 2013
Inhibiting carbonic anhydrase (CA) in the plasma abolished this effect.
A proteomic study of protein variation between osteopenic and age-matched control bone tissue.
Wayne Sampson et al., Temple, United States. In Exp Biol Med (maywood), 2012
carbonic anhydrase I, phosphoglycerate kinase 1 and apolipoprotein A-I appeared to be the most significant variations of proteins in patients with osteopenia and osteoarthritis
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.
Supuran et al., Balıkesir, Turkey. In Bioorg Med Chem, 2010
single mutation of an amino acid not considered essential to catalysis (Phe91Asn) in carbonic anhydrase I, but is near substrate binding pocket, led to increase of catalytic activity; mutant CA I also showed higher affinity for sulfonamide inhibitors
Increased expression of carbonic anhydrase I in the synovium of patients with ankylosing spondylitis.
Cui et al., Jinan, China. In Bmc Musculoskelet Disord, 2009
Overexpression of CA1 in the synovial tissues of ankylosing spondylitis (AS) patients may promote improper calcification and bone resorption in AS.
Decreased total carbonic anhydrase esterase activity and decreased levels of carbonic anhydrase 1 isozyme in erythrocytes of type II diabetic patients.
Bonar et al., Washington, D.C., United States. In Biochem Genet, 2007
Decreased levels of carbonic anhydrase 1 isozyme is associated with type II diabetes.
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