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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

TBC1 domain family, member 10C

Carabin, TBC1D10C
The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromsomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012] (from NCBI)
Top mentioned proteins: GAP, Rab5, OUT, Transferrin, TBC
Papers on Carabin
Carabin protects against cardiac hypertrophy by blocking calcineurin, Ras, and Ca2+/calmodulin-dependent protein kinase II signaling.
New
Lezoualc'h et al., Montpellier, France. In Circulation, Feb 2015
METHODS AND RESULTS: Here, we characterized Carabin, a protein expressed in cardiomyocytes that was downregulated in cardiac hypertrophy and human heart failure.
All members of the EPI64 subfamily of TBC/RabGAPs also have GAP activities towards Ras.
Nakamura et al., Noda, Japan. In J Biochem, 2013
EPI64C/TBC1D10C/carabin, a haematopoietically enriched GTPase-activating protein (GAP) for Rab35, has been shown to exhibit RasGAP activity.
Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity.
Soulas-Sprauel et al., Strasbourg, France. In Embo Mol Med, 2012
Here, we show that Carabin is low in B cells of (NZB × NZW) F1 mice (murine SLE model) long before the disease onset, and is low in B cells of lupus patients during the inactive phases of the disease.
Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.
Shaw et al., Bethesda, United States. In J Biol Chem, 2008
EPI64C (TBC1D10C) is an uncharacterized candidate RabGAP we identified by mass spectrometry as abundant in human peripheral blood T cells that is preferentially expressed in hematopoietic cells.
Feedback inhibition of calcineurin and Ras by a dual inhibitory protein Carabin.
Impact
GeneRIF
Liu et al., Baltimore, United States. In Nature, 2007
Carabin is a negative feedback inhibitor of the calcineurin signalling pathway that also mediates crosstalk between calcineurin and Ras
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