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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.


This gene encodes a calcium-binding protein, which may play a role in the regulation of ion transport. A similar protein was first described as a potentially important regulatory protein in the dog thyroid and was termed as R2D5 antigen in rabbit. Alternative splicing of this gene generates two transcript variants. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAD, CAN, IL-1beta, ACID, OUT
Papers on CAPS
Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin.
Carnevale et al., Ţanţā, Egypt. In Proc Natl Acad Sci U S A, Feb 2016
The recent cryo-electron microscopy structure of TRPV1 only provides a coarse characterization of the location of capsaicin (CAPS) and resiniferatoxin (RTX).
Development of new SNP derived cleaved amplified polymorphic sequence marker set and its successful utilization in the genetic analysis of seed color variation in barley.
Naz et al., Bonn, Germany. In Genomics, Jan 2016
UNASSIGNED: The aim of the present study was to develop a new cost effective PCR based CAPS marker set using advantages of high-throughput SNP genotyping.
Resident CAPS on dense-core vesicles docks and primes vesicles for fusion.
Martin et al., Madison, United States. In Mol Biol Cell, Jan 2016
CAPS (aka CADPS) is one of several factors required for vesicle priming, however, the localization and dynamics of CAPS at sites of exocytosis in live neuroendocrine cells has not been determined.
Beyond the continuum: a multi-dimensional phase space for neutral-niche community assembly.
McGeoch et al., Cape Town, South Africa. In Proc Biol Sci, Jan 2016
By contrast, we introduce the Community Assembly Phase Space (CAPS), a multi-dimensional space that uses community processes (such as dispersal and niche selection) to define the limiting neutral and niche conditions and to test the continuum hypothesis.
The role of infectious diseases in the catastrophic antiphospholipid syndrome.
Cervera et al., Mexico. In Autoimmun Rev, Nov 2015
Catastrophic antiphospholipid syndrome (CAPS), also called "Asherson syndrome", is a variant of the antiphospholipid syndrome (APS) that occurs in less than 1% of APS cases.
From bench to bedside and back again: translational research in autoinflammation.
Gattorno et al., Münster, Germany. In Nat Rev Rheumatol, Oct 2015
Patients with common complex multifactorial diseases such as systemic-onset juvenile idiopathic arthritis (sJIA), and particularly those with rare monogenic autoinflammatory diseases such as cryopyrin-associated periodic syndromes (CAPS) or TNF receptor-associated periodic syndrome (TRAPS), benefited from a deeper understanding of the pathophysiological mechanisms and new treatment options emerging from preclinical studies.
Recommendations for the management of autoinflammatory diseases.
Kuemmerle-Deschner et al., Utrecht, Netherlands. In Ann Rheum Dis, Sep 2015
One of the aims of SHARE was to provide evidence-based recommendations for the management of the autoinflammatory diseases cryopyrin-associated periodic syndromes (CAPS), tumour necrosis factor (TNF) receptor-associated periodic syndrome (TRAPS) and mevalonate kinase deficiency (MKD).
[Diagnosis and Clinical Examination of Autoinflammatory Syndrome].
Ida, In Rinsho Byori, May 2015
The main monogenic autoinflammatory syndromes are familial Mediterranean fever (FMF), TNF receptor-associated periodic syndrome (TRAPS), mevalonate kinase deficiency (MKD), cryopyrin-associated periodic syndrome (CAPS), Blau syndrome, and pyogenic arthritis, pyoderma gangrenosum, and acne (PAPA) syndrome.
A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.
O'Neill et al., Dublin, Ireland. In Nat Med, Mar 2015
The NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inflammasome is a component of the inflammatory process, and its aberrant activation is pathogenic in inherited disorders such as cryopyrin-associated periodic syndrome (CAPS) and complex diseases such as multiple sclerosis, type 2 diabetes, Alzheimer's disease and atherosclerosis.
Major Quantitative Trait Loci and Putative Candidate Genes for Powdery Mildew Resistance and Fruit-Related Traits Revealed by an Intraspecific Genetic Map for Watermelon (Citrullus lanatus var. lanatus).
Park et al., Miryang, South Korea. In Plos One, 2014
The map consists of 14 linkage groups (LGs) defined by 174 cleaved amplified polymorphic sequences (CAPS), 2 derived-cleaved amplified polymorphic sequence markers, 20 sequence-characterized amplified regions, and 8 expressed sequence tag-simple sequence repeat markers spanning 1,404.3
Current treatment recommendations and considerations for cryopyrin-associated periodic syndrome.
Galeotti et al., Le Kremlin-Bicêtre, France. In Expert Rev Clin Immunol, 2014
Cryopyrin-associated periodic syndrome (CAPS) encompasses a spectrum of three phenotypes of increasing severity.
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome.
Goldbach-Mansky et al., Bethesda, United States. In Nat Genet, 2014
The discovery that dominant gain-of-function mutations in NLRP3 cause the cryopyrin-associated periodic syndromes (CAPS) and trigger spontaneous inflammasome activation and IL-1β oversecretion led to successful treatment with IL-1-blocking agents.
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response.
Pelegrín et al., Murcia, Spain. In Nat Immunol, 2014
Recombinant oligomeric protein particles composed of the adaptor ASC or the p.D303N mutant form of NLRP3 associated with cryopyrin-associated periodic syndromes (CAPS) stimulated further activation of caspase-1 extracellularly, as well as intracellularly after phagocytosis by surrounding macrophages.
The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP.
Chae et al., Bethesda, United States. In Nature, 2013
Mutations in the gene encoding NLRP3 cause a spectrum of autoinflammatory diseases known as cryopyrin-associated periodic syndromes (CAPS).
Distinct initial SNARE configurations underlying the diversity of exocytosis.
Tokumaru et al., Tokyo, Japan. In Physiol Rev, 2012
The initial SNARE configurations depend on the particular SNARE subtype (syntaxin, SNAP25, or VAMP), priming proteins (Munc18, Munc13, CAPS, complexin, or snapin), triggering proteins (synaptotagmins, Doc2, and various protein kinases), and the submembraneous cytomatrix, and they are the key to determining the kinetics of subsequent exocytosis.
Calcium-dependent activator protein for secretion 2 interacts with the class II ARF small GTPases and regulates dense-core vesicle trafficking.
Furuichi et al., Japan. In Febs J, 2012
CAPS family proteins exert dual roles in DCV trafficking, mediating trafficking at both the secretion site for exocytosis and at the Golgi complex for biogenesis
Expression of Ca²⁺-dependent activator protein for secretion 2 is increased in the brains of schizophrenic patients.
Kunugi et al., Kodaira, Japan. In Prog Neuropsychopharmacol Biol Psychiatry, 2011
Increased level of CADPS protein, human in Schizophrenic patients
Munc13 homology domain-1 in CAPS/UNC31 mediates SNARE binding required for priming vesicle exocytosis.
Martin et al., Madison, United States. In Cell Metab, 2011
The results show that Munc13 homology domain-1 is a SNARE-binding domain and that SNARE protein binding is essential for CAPS function in dense-core vesicle exocytosis.
Genome-wide molecular characterization of central nervous system primitive neuroectodermal tumor and pineoblastoma.
Grundy et al., Nottingham, United Kingdom. In Neuro Oncol, 2011
Loss of CADPS is associated with central nervous system primitive neuroectodermal tumor.
Interaction of calcium-dependent activator protein for secretion 1 (CAPS1) with the class II ADP-ribosylation factor small GTPases is required for dense-core vesicle trafficking in the trans-Golgi network.
Furuichi et al., Wako, Japan. In J Biol Chem, 2011
a functional role for CAPS1 in regulating DCV trafficking in the trans-Golgi network; this activity occurs via protein-protein interaction with ARF4/ARF5 in a GDP-dependent manner.
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