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Nitric oxide synthase 1

CAPON, NOS1AP
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: iNOS, CAN, HAD, Tec, AGE
Papers on CAPON
Genetic assessment of additional endophenotypes from the Consortium on the Genetics of Schizophrenia Family Study.
New
Braff et al., San Diego, United States. In Schizophr Res, Jan 2016
Genotyping via a custom array of 1536 SNPs from 94 candidate genes identified associations for CTNNA2, ERBB4, GRID1, GRID2, GRIK3, GRIK4, GRIN2B, NOS1AP, NRG1, and RELN across multiple endophenotypes.
Weighted Capon beamformer combined with coded excitation in ultrasound imaging.
New
Asl et al., Tehrān, Iran. In J Med Ultrason (2001), Oct 2015
BACKGROUND: Capon-based beamformers are well-known methods to improve the SNR and quality of medical ultrasound images.
High-contrast and low-computational complexity medical ultrasound imaging using beamspace capon method.
New
Sato et al., In Conf Proc Ieee Eng Med Biol Soc, Aug 2015
The beamspace (BS) Capon method is one common method used to depict high-resolution images with low computational complexity.
Neuronal nitric oxide synthase (NOS1) and its adaptor, NOS1AP, as a genetic risk factors for psychiatric disorders.
Review
Reif et al., Frankfurt am Main, Germany. In Genes Brain Behav, 2015
Both NOS1 and its interaction partner NOS1AP have a role therein.
Phosphorylated neuronal nitric oxide synthase in neuropathic pain in rats.
Xu et al., Nanchang, China. In Int J Clin Exp Pathol, 2014
By administration of KN93, the interaction of nNOS and the adaptor protein CAPON was reduced through inhibition of CaMK II by KN93.
CAPON-nNOS coupling can serve as a target for developing new anxiolytics.
Impact
Zhu et al., Nanjing, China. In Nat Med, 2014
Here we report that the coupling between neuronal nitric oxide synthase (nNOS) and its carboxy-terminal PDZ ligand (CAPON) can serve as a target for developing new anxiolytic agents.
The paraventricular nucleus and heart failure.
Review
Pyner, Durham, United Kingdom. In Exp Physiol, 2014
In heart failure, the cell signalling protein partners CAPON and PIN decrease the bioavailability of nitric oxide by inhibiting neuronal nitric oxide synthase activity, leading to the removal of tonic neuronal inhibition.
Mechanisms of NOS1AP action on NMDA receptor-nNOS signaling.
Review
Lai et al., Kuopio, Finland. In Front Cell Neurosci, 2013
nNOS adaptor protein (NOS1AP), originally described as a competitor of PSD95:nNOS interaction, is regarded an inhibitor of NMDAR-driven nNOS function.
Nitric oxide in the nervous system: biochemical, developmental, and neurobiological aspects.
Review
Paes-de-Carvalho et al., Niterói, Brazil. In Vitam Horm, 2013
In the central nervous system (CNS), NO synthesis usually requires a functional coupling of nitric oxide synthase I (NOS I) and proteins such as NMDA receptors or carboxyl-terminal PDZ ligand of NOS (CAPON), which is critical for specificity and triggering of selected pathways.
Common variation in the NOS1AP gene is associated with drug-induced QT prolongation and ventricular arrhythmia.
GeneRIF
Behr et al., London, United Kingdom. In J Am Coll Cardiol, 2012
Common variations in the NOS1AP gene are associated with a significant increase in the risk of drug-induced long QT syndrome.
A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression.
GeneRIF
Moon et al., Seattle, United States. In Oncogene, 2012
NOS1AP colocalizes with both SCRIB and VANGL1 along cellular protrusions in metastatic breast cancer cells, but does not colocalize with either SCRIB or VANGL1 at cell junctions in normal breast cells
[Association of Schizophrenia and its Clinical Implications with the NOS1AP Gene in the Colombian Population].
Berrío et al., Medellín, Colombia. In Rev Colomb Psiquiatr, 2012
INTRODUCTION: The nitric oxide synthase 1 adaptor protein (NOS1AP) gene is possibly implicated in schizophrenia etiopathogenesis.
Decreased nNOS in the PVN leads to increased sympathoexcitation in chronic heart failure: role for CAPON and Ang II.
GeneRIF
Patel et al., Omaha, United States. In Cardiovasc Res, 2011
nNOS and CAPON co-localize in the pre-sympathetic autonomic neurons in the paraventricular nucleus and their expression is reciprocally regulated in congestive heart failure via angiotensin II.
Association of rs10918594 polymorphisms of nitric oxide synthase 1 adaptor protein (NOS1AP) with QTc interval prolongation during kidney transplantation.
GeneRIF
Bohatyrewicz et al., Szczecin, Poland. In Transplant Proc, 2011
NOS1AP rs203462 polymorphisms did not correlate with an increased risk of QT interval prolongation among kidney recipients.
Association of the rs10918594 of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphisms with the graft function after kidney transplantation.
GeneRIF
Bohatyrewicz et al., Szczecin, Poland. In Ann Transplant, 2011
relationship of nitric oxide synthase 1 adaptor protein (NOS1AP) polymorphism with serum creatinine level and occurrence of delayed graft function in kidney transplant recipients
Research progress on neurobiology of neuronal nitric oxide synthase.
Review
Zhu et al., Nanjing, China. In Neurosci Bull, 2011
There are primarily 9 nNOS-interacting proteins, including post-synaptic density protein 95 (PSD95), clathrin assembly lymphoid leukemia (CALM), calcium/calmodulin-dependent protein kinase II alpha (CAMKIIA), Disks large homolog 4 (DLG4), DLG2, 6-phosphofructokinase, muscle type (PFK-M), carboxy-terminal PDZ ligand of nNOS (CAPON) protein, syntrophin and dynein light chain (LC).
GAPDH mediates nitrosylation of nuclear proteins.
Impact
Snyder et al., Baltimore, United States. In Nat Cell Biol, 2010
5) and CAPON.
Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
Impact
Chakravarti et al., München, Germany. In Nat Genet, 2009
A common variant in NOS1AP is known to influence repolarization.
Common variants at ten loci influence QT interval duration in the QTGEN Study.
Impact
Stricker et al., Boston, United States. In Nat Genet, 2009
We observed associations at P < 5 x 10(-8) with variants in NOS1AP, KCNQ1, KCNE1, KCNH2 and SCN5A, known to be involved in myocardial repolarization and mendelian long-QT syndromes.
A common genetic variant in the NOS1 regulator NOS1AP modulates cardiac repolarization.
Impact
GeneRIF
Chakravarti et al., Baltimore, United States. In Nat Genet, 2006
This genome-wide study identified NOS1AP (CAPON), a regulator of neuronal nitric oxide synthase, as a new target that modulates cardiac repolarization
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