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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Calpain, small subunit 1

Capn4, Capns1, calpain small subunit 1, Calpain 4, CSS-1
Top mentioned proteins: Calpain, calpain 2, mu-Cl, CAN, calpastatin
Papers on Capn4
Calpain restrains the stem cells compartment in breast cancer.
Demarchi et al., Trieste, Italy. In Cell Cycle, Feb 2016
CAPNS1 is essential for the stability and function of ubiquitous CAPN1 and CAPN2.
Mitochondrial Calpain-1 Disrupts ATP Synthase and Induces Superoxide Generation in Type 1 Diabetic Hearts: A Novel Mechanism Contributing to Diabetic Cardiomyopathy.
Peng et al., London, Canada. In Diabetes, Jan 2016
T1D was induced in transgenic mice overexpressing calpastatin, in mice with cardiomyocyte-specific capn4 deletion, or in their wild-type littermates by injection of streptozotocin.
Deletion of capn4 Protects the Heart Against Endotoxemic Injury by Preventing ATP Synthase Disruption and Inhibiting Mitochondrial Superoxide Generation.
Peng et al., Suzhou, China. In Circ Heart Fail, Sep 2015
In this study, we used cardiomyocyte-specific capn4 knockout mice to investigate whether and how calpain disrupts ATP synthase and induces mitochondrial superoxide generation during endotoxemia.
Receptor-Interacting Protein 140 Orchestrates the Dynamics of Macrophage M1/M2 Polarization.
Wei et al., Minneapolis, United States. In J Innate Immun, Aug 2015
The M2-suppressive effect is elicited by a new function of RIP140 that, in macrophages exposed to M2 cues, is exported to cytosol, forming complexes with CAPNS1 (calpain regulatory subunit) to activate calpain 1/2, that activates PTP1B phosphatase.
Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
Ge et al., Shanghai, China. In Med Oncol, Mar 2015
The expression of calpain small subunit 1 (Capn4) is correlated with the invasion of several types of tumors.
Differential Genes Expression between Fertile and Infertile Spermatozoa Revealed by Transcriptome Analysis.
Rajender et al., Lucknow, India. In Plos One, 2014
Some transcripts were specific to the normozoospermic group (up-regulated: CAPNS1, FAM153C, ARF1, CFL1, RPL19, USP22; down-regulated: ZNF90, SMNDC1, c14orf126, HNRNPK), while some were specific to the asthenozoospermic group (up-regulated: RPL24, HNRNPM, RPL4, PRPF8, HTN3, RPL11, RPL28, RPS16, SLC25A3, C2orf24, RHOA, GDI2, NONO, PARK7; down-regulated: HNRNPC, SMARCAD1, RPS24, RPS24, RPS27A, KIFAP3).
Inhibition of microvesiculation sensitizes prostate cancer cells to chemotherapy and reduces docetaxel dose required to limit tumor growth in vivo.
Inal et al., London, United Kingdom. In Sci Rep, 2014
To see whether such drugs could be used at lower concentrations with the same efficacy, it was first shown that microvesiculation of prostate cancer (PCa) cells, PC3, could be inhibited pharmacologically with calpeptin (calpain inhibitor) and by siRNA (CAPNS1).
Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice.
Jepsen et al., Ann Arbor, United States. In Bone, 2014
Seven substitutions showed altered robustness, cortical area, or TMD, but no effect on mechanical function (CSS-4, 5, 8, 9, 17, 18, 19); six substitutions showed altered robustness, cortical area, or TMD, and reduced mechanical function (CSS-1, 2, 6, 10, 12, 15); and one substitution also showed reduced mechanical function but exhibited no significant changes in the three physical traits analyzed in this study (CSS-3).
Effects of laser treatment on the expression of cytosolic proteins in the synovium of patients with osteoarthritis.
Szekanecz et al., Budapest, Hungary. In Lasers Surg Med, 2014
The expression of the other proteins (calpain small subunit 1, tubulin alpha-1C and beta 2, vimentin variant 3, annexin A1, annexin A5, cofilin 1, transgelin, and collagen type VI alpha 2 chain precursor) significantly decreased (P < 0.05) compared to the control samples.
Increased expression of Capn4 is associated with the malignancy of human glioma.
Mao et al., Shanghai, China. In Cns Neurosci Ther, 2014
AIMS: Recent evidence indicates that the increased expression of calpain small subunit 1 (Capn4) is associated with tumorigenesis.
Differential expression of transcription factors and inflammation-, ROS-, and cell death-related genes in organotypic cultures in the modiolus, the organ of Corti and the stria vascularis of newborn rats.
Mazurek et al., Berlin, Germany. In Cell Mol Neurobiol, 2014
The results provide two coexpression clusters across the three regions, a Hif-1a coexpression cluster and a cluster around the cell death-associated transcripts Casp3, Capn1, Capn2, and Capns1.
Altered expression of platelet proteins and calpain activity mediate hypoxia-induced prothrombotic phenotype.
Ashraf et al., Delhi, India. In Blood, 2014
Among these proteins, calpain small subunit 1, a 28-kDa regulatory component for calpain function, was significantly upregulated under hypoxic conditions.
Scleral gene expression during recovery from myopia compared with expression during myopia development in tree shrew.
Norton et al., Birmingham, United States. In Mol Vis, 2013
Eight of these genes (NPR3, CAPNS1, NGEF, TGFB1, CTGF, NOV, TIMP1, and HS6ST1) were bidirectionally regulated at both time points in the GO and STOP conditions.
Deficiency of Capn4 gene inhibits nuclear factor-κB (NF-κB) protein signaling/inflammation and reduces remodeling after myocardial infarction.
Peng et al., London, Canada. In J Biol Chem, 2012
effects of Capn4 deletion may be mediated through prevention of IkappaB degradation and NF-kappaB activation, resulting in inhibition of inflammatory responses.
Galectin-3 secretion and tyrosine phosphorylation is dependent on the calpain small subunit, Calpain 4.
Beningo et al., Detroit, United States. In Biochem Biophys Res Commun, 2011
Calpain 4 is essential for the tyrosine phosphorylation of galectin-3, and its ultimate secretion from the cell, and its secretion probably interferes with the production of traction forces.
A high fat diet-induced impaired glucose metabolism in mice with targeted deletion of calpain in osteoblasts.
Shimada et al., Boston, United States. In Biochem Biophys Res Commun, 2011
osteoblast-specific Capns1 knockout mice with osteoporosis and reduced bone resorptive function, exhibited reduced serum uncarboxylated osteocalcin levels and a lean phenotype under a normal chow diet.
Targeted deletion of Capn4 in cells of the chondrocyte lineage impairs chondrocyte proliferation and differentiation.
Shimada et al., Boston, United States. In Mol Cell Biol, 2010
Data suggest that the calpain small subunit, Capn4, is essential for proper chondrocyte functions in embryonic growth plates.
Calpain 4 is not necessary for LFA-1-mediated function in CD4+ T cells.
Huttenlocher et al., Madison, United States. In Plos One, 2009
Calpain 4 is not necessary for LFA-1-mediated adhesion, conjugation or migration.
The calpain system as a modulator of stress/damage response.
Schneider et al., Trieste, Italy. In Cell Cycle, 2007
Ubiquitously expressed mu- and m-calpain proteases consist of 80-kDa catalytic subunits encoded by the Capn1 and Capn2 genes, respectively, and a common 28-kDa regulatory subunit encoded by the calpain small 1 (Capns1) gene.
Calpain inhibition: a therapeutic strategy targeting multiple disease states.
Carragher, Glasgow, United Kingdom. In Curr Pharm Des, 2005
Recent advances in elucidating the tertiary structures of calpain 2 and its regulatory domain calpain 4, together with identification of new modes of regulating calpain activity provide new opportunities for the design of novel calpain inhibitors.
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