The NEDD8 modification pathway in plants.
Freising, Germany. In Front Plant Sci, 2013
In turn, NEDD8 deconjugation destabilizes the cullin RING ligase complex allowing for the exchange of substrate recognition subunits via the exchange factor CAND1.
Structural regulation of cullin-RING ubiquitin ligase complexes.
Memphis, United States. In Curr Opin Struct Biol, 2011
Recent structural studies have revealed numerous ways in which CRL E3 ligase activities are controlled, including multimodal E3 ligase activation by covalent attachment of the ubiquitin-like protein NEDD8, inhibition of CRL assembly/activity by CAND1, and several mechanisms of regulated substrate recruitment.
Regulation of cullin RING ligases.
Davis, United States. In Annu Rev Plant Biol, 2007
CULLIN-ASSOCIATED NEDD8-DISSOCIATED 1 (CAND1) interacts with CRLs, affecting both rubylation and derubylation.