gopubmed logo
 
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Aug 2016.

Centromere protein W

Cancer-upregulated gene 2, CUG2, CENP-W
Top mentioned proteins: Histone, Gli, CAN, CENP-C, p38
Papers on Cancer-upregulated gene 2
A new kinetochore component CENP-W interacts with the polycomb-group protein EZH2 to promote gene silencing.
New
Lee et al., Taejŏn, South Korea. In Biochem Biophys Res Commun, Sep 2015
CENP-W was originally identified as a putative oncogene overexpressed in various human tumors, and later characterized as an essential factor for the formation of functional kinetochore during mitosis.
A phase I trial of single-agent reolysin in patients with relapsed multiple myeloma.
Hofmeister et al., Columbus, United States. In Clin Cancer Res, 2015
Bone marrow specimens were examined by in situ-based hybridization (ISH) for CD138, p38, caspase-3, reoviral RNA, and capsid protein at screening and cycle 1 day 8. Junctional adhesion molecule 1 (JAM-1) and cancer upregulated gene 2 (CUG2) were evaluated in patient samples and multiple myeloma cell lines.
The distinct functions of CENP-C and CENP-T/W in centromere propagation and function in Xenopus egg extracts.
Losada et al., Madrid, Spain. In Nucleus, 2014
Taking advantage of the Xenopus egg cell-free system, we have addressed these issues for CCAN proteins CENP-C, CENP-T and CENP-W.
Suppression of autophagic genes sensitizes CUG2-overexpressing A549 human lung cancer cells to oncolytic vesicular stomatitis virus-induced apoptosis.
Chung et al., Pusan, South Korea. In Int J Oncol, 2014
Since many studies have reported that autophagy is involved in virus replication, we investigated whether autophagy also plays a role in the antiviral activity in A549 cells overexpressing CUG2 (A549-CUG2).
The centromeric nucleosome-like CENP-T-W-S-X complex induces positive supercoils into DNA.
Fukagawa et al., Fukuoka, Japan. In Nucleic Acids Res, 2014
We found that the DNA-binding regions in CENP-T or CENP-W, but not CENP-S or CENP-X, are required for this positive supercoiling activity and the kinetochore targeting of the CENP-T-W-S-X complex.
CENP-W plays a role in maintaining bipolar spindle structure.
Sullivan et al., Galway, Ireland. In Plos One, 2013
The CENP-W/T complex was previously reported to be required for mitosis.
Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation.
Chung et al., Pusan, South Korea. In Int J Oncol, 2013
We recently showed that CUG2 elevates STAT1 activity, leading to resistance to infection by oncolytic vesicular stomatitis virus.
CSN5/JAB1 interacts with the centromeric components CENP-T and CENP-W and regulates their proteasome-mediated degradation.
Lee et al., Taejŏn, South Korea. In J Biol Chem, 2013
Co-immunoprecipitation revealed that CSN5 directly interacts with both CENP-T and CENP-W.
Cancer upregulated gene 2, a novel oncogene, confers resistance to oncolytic vesicular stomatitis virus through STAT1-OASL2 signaling.
Chung et al., Pusan, South Korea. In Cancer Gene Ther, 2013
We have recently found a novel oncogene, named cancer upregulated gene 2 (CUG2), which activates Ras and mitogen-activated protein kinases (MAPKs), including ERK, JNK and p38 MAPK.
T time for point centromeres.
Impact
Cheeseman et al., In Nat Cell Biol, 2012
Two studies now challenge this dogma with the identification of budding yeast homologues of the vertebrate centromere DNA-binding proteins CENP-T and CENP-W.
Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.
GeneRIF
Franceschini et al., Seattle, United States. In Hum Mol Genet, 2012
Single nucleotide polymorphism in CENPW is associated with the length of reproductive lifespan.
New centromeric component CENP-W is an RNA-associated nuclear matrix protein that interacts with nucleophosmin/B23 protein.
GeneRIF
Lee et al., Taejŏn, South Korea. In J Biol Chem, 2012
B23 may function in the assembly of the kinetochore complex by interacting with CENP-W during interphase
The ABCs of CENPs.
Review
Fukagawa et al., Mishima, Japan. In Chromosoma, 2011
Onto centromeric CENP-A chromatin is assembled the so-called constitutive centromere-associated network (CCAN) of 16 proteins distributed in several functional groups as follows: CENP-C, CENP-H/CENP-I/CENP-K/, CENP-L/CENP-M/CENP-N, CENP-O/CENP-P/CENP-Q/CENP-R/CENP-U(50), CENP-T/CENP-W, and CENP-S/CENP-X.
Premitotic assembly of human CENPs -T and -W switches centromeric chromatin to a mitotic state.
GeneRIF
Sullivan et al., Galway, Ireland. In Plos Biol, 2011
The CENP-T/W complex assembles through a dynamic exchange mechanism in late S-phase and G2, is required for mitosis in each cell cycle and does not persist across cell generations.
Real-time PCR and multiplex approaches.
Skoblov et al., Moscow, Russia. In Methods Mol Biol, 2010
Here, we describe application of multiplex real-time RT-PCR using TaqMan probes in the analysis of relative expression levels of a novel tumor-associated gene CUG2 in cell lines and tissue samples.
Cug2 is essential for normal mitotic control and CNS development in zebrafish.
Kim et al., Taejŏn, South Korea. In Bmc Dev Biol, 2010
BACKGROUND: We recently identified a novel oncogene, Cancer-upregulated gene 2 (CUG2), which is essential for kinetochore formation and promotes tumorigenesis in mammalian cells.
Sp1 and Sp3 mediate basal and serum-induced expression of human CENP-W.
GeneRIF
Lee et al., Taejŏn, South Korea. In Mol Biol Rep, 2010
Sp1 together with Sp3 may function as the main regulator of the basal and serum-induced transcription of CENP-W.
Cancer-upregulated gene 2 (CUG2) overexpression induces apoptosis in SKOV-3 cells.
GeneRIF
Lee et al., Taejŏn, South Korea. In Cell Biochem Funct, 2010
Overexpression of CUG2 induces apoptosis in SKOV-3 cells.
CCAN makes multiple contacts with centromeric DNA to provide distinct pathways to the outer kinetochore.
Impact
GeneRIF
Fukagawa et al., Mishima, Japan. In Cell, 2009
Study demonstrates that CENP-W forms a DNA-binding complex together with the CCAN component CENP-T; this complex directly associates with nucleosomal DNA and with canonical histone H3, but not with CENP-A, in centromeric regions.
share on facebooktweetadd +1mail to friends