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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 06 Oct 2015.

Hepatic and glial cell adhesion molecule

Cancer susceptibility, hepaCAM
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, AGE, HAD, Iris, POLYMERASE
Papers on Cancer susceptibility
Association and Intragenic Single-Nucleotide Polymorphism Interactions of the XRCC1 Polymorphisms for Pancreatic Cancer Susceptibility.
Ou et al., Guangzhou, China. In Pancreas, 24 Oct 2015
OBJECTIVES: X-ray repair cross-complementing group 1 (XRCC1) gene is an important candidate gene for influencing human cancer risks.
Impact of PTEN IVS4 Polymorphism (rs3830675) on Cancer Susceptibility: An Updated Meta-analysis.
Ge et al., San Francisco, United States. In Cancer Genomics Proteomics, 10 Oct 2015
BACKGROUND/AIM: Phosphatase and tensin homolog (PTEN) acts as a tumor suppressor gene through the action of its phosphatase protein product.
American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility.
Lindor et al., Philadelphia, United States. In J Clin Oncol, 01 Oct 2015
In particular, there was an interest in addressing the opportunities and challenges arising from the application of massively parallel sequencing-also known as next-generation sequencing-to cancer susceptibility testing.
The Role of Methylation in Breast Cancer Susceptibility and Treatment.
Durocher et al., Québec, Canada. In Anticancer Res, 30 Sep 2015
DNA methylation is a critical mechanism of epigenetic modification involved in gene expression programming, that can promote the development of several cancers, including breast cancer.
Cytochrome P450 in Cancer Susceptibility and Treatment.
Agarwal et al., Lucknow, India. In Adv Clin Chem, Dec 2014
Association studies and meta-analyses have been performed to decipher the role of CYP450 polymorphisms in cancer susceptibility.
Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility.
Liu et al., Yangzhou, China. In Gastroenterol Res Pract, Dec 2014
Association Between ESR1 PvuII, XbaI, and P325P Polymorphisms and Breast Cancer Susceptibility: A Meta-Analysis.
Jiang et al., Changzhou, China. In Med Sci Monit, Dec 2014
CONCLUSIONS Thus, this meta-analysis clarified the inconsistent conclusions from previous studies, conducted analyses for the entire population as well as for different subgroups using diverse population categorization strategies, and has the potential to help provide a personalized risk estimate for breast cancer susceptibility.
The GADD45A (1506T>C) Polymorphism Is Associated with Ovarian Cancer Susceptibility and Prognosis.
Kong et al., China. In Plos One, Dec 2014
We are the first group to demonstrate that the GADD45A (1506T>C) polymorphism is associated with ovarian cancer susceptibility and prognosis.
Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis.
Yin et al., Nanjing, China. In Int J Genomics, 2013
Nuclear factor- κ B is associated with the pathogenesis of numerous malignancies, and the functional polymorphism -94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk.
The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.
Paul et al., Kansas City, United States. In Front Biosci, 2013
The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of genomic integrity.
Exploration of the correlations between interferon-γ in patient serum and HEPACAM in bladder transitional cell carcinoma, and the interferon-γ mechanism inhibiting BIU-87 proliferation.
Zhang et al., Anqing, China. In J Urol, 2012
Results suggest an important connection between HEPACAM and interferon-gamma, which may inhibit BIU-87 proliferation through HEPACAM re-expression and p21(WAF1) up-regulation to arrest cells at the G(0)/G(1) phase
HepaCAM induces G1 phase arrest and promotes c-Myc degradation in human renal cell carcinoma.
Shen et al., Chongqing, China. In J Cell Biochem, 2011
Research implies that the decrease in c-Myc protein expression, resulting from ectopic expression of hepaCAM, may contribute to the inhibition of proliferation in these cells.
Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts.
Estévez et al., Barcelona, Spain. In Hum Mol Genet, 2011
study presents more detailed characterization of the effect of mutations found in MLC1 and GLIALCAM megalencephalic leukoencephalopathy with subcortical cysts
Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism.
van der Knaap et al., Barcelona, Spain. In Am J Hum Genet, 2011
Dominant HEPACAM mutations can cause either macrocephaly and mental retardation with or without autism or benign familial macrocephaly.
Cancer evolution and individual susceptibility.
Mao et al., Salamanca, Spain. In Integr Biol (camb), 2011
Cancer susceptibility is due to interactions between inherited genetic factors and exposure to environmental carcinogens.
Subtle variations in Pten dose determine cancer susceptibility.
Pandolfi et al., Boston, United States. In Nat Genet, 2010
Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG).
Exon 2 methylation inhibits hepaCAM expression in transitional cell carcinoma of the bladder.
Shen et al., Chongqing, China. In Urol Int, 2009
Downregulation of hepaCAM expression plays an important role in the tumorigenesis and development of bladder cancer
Cancer susceptibility in the mouse: genetics, biology and implications for human cancer.
Demant, Buffalo, United States. In Nat Rev Genet, 2003
Growing evidence that a large proportion of apparently non-hereditary sporadic cancers occur in genetically predisposed individuals has emphasized the need to identify the underlying susceptibility genes.
American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility.
American Society of Clinical Oncology, In J Clin Oncol, 2003
The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice, research needs, educational opportunities, requirement for informed consent, indications for genetic testing, regulation of laboratories, and protection from discrimination, as well as access to and reimbursement for cancer genetics services.
Cancer susceptibility and the functions of BRCA1 and BRCA2.
Venkitaraman, Cambridge, United Kingdom. In Cell, 2002
Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
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