GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 04 Dec 2014.
Hepatic and glial cell adhesion molecule
Cancer susceptibility, hepaCAM
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011] (from
Tian et al., Jinhua, China. In Med Sci Monit, Dec 2013
UNLABELLED: Background As 2 important SNPs located in the promoter region of VEGF gene, the roles of rs833061 (-460C>T) and rs699947 (-2578C>A) in lung cancer susceptibility and survival remain inconclusive and controversial.
This study explored the association between lung cancer susceptibility loci tagged by single-nucleotide polymorphisms (SNPs) identified in the genome-wide association studies and length of survival in small-cell lung cancer (SCLC).
Results suggest an important connection between HEPACAM and interferon-gamma, which may inhibit BIU-87 proliferation through HEPACAM re-expression and p21(WAF1) up-regulation to arrest cells at the G(0)/G(1) phase
Demant, Buffalo, United States. In Nat Rev Genet, 2003
Growing evidence that a large proportion of apparently non-hereditary sporadic cancers occur in genetically predisposed individuals has emphasized the need to identify the underlying susceptibility genes.
American Society of Clinical Oncology, In J Clin Oncol, 2003
The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice, research needs, educational opportunities, requirement for informed consent, indications for genetic testing, regulation of laboratories, and protection from discrimination, as well as access to and reimbursement for cancer genetics services.