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Hepatic and glial cell adhesion molecule

Cancer susceptibility, hepaCAM
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: AGE, CAN, HAD, Iris, POLYMERASE
Papers on Cancer susceptibility
Inherited Mutations in 17 Breast Cancer Susceptibility Genes Among a Large Triple-Negative Breast Cancer Cohort Unselected for Family History of Breast Cancer.
Fasching et al., Rochester, United States. In J Clin Oncol, 01 Jan 2015
PURPOSE: Recent advances in DNA sequencing have led to the development of breast cancer susceptibility gene panels for germline genetic testing of patients.
A Genetic Lung Cancer Susceptibility Test may have a Positive Effect on Smoking Cessation.
Thirlaway et al., Newcastle upon Tyne, United Kingdom. In J Genet Couns, 19 Dec 2014
Genetic loci have been identified which could form the basis of a lung cancer susceptibility test; but little is known whether such a test would interest or motivate those trying to quit smoking.
A Systems Genetics Approach Identifies CXCL14, ITGAX, and LPCAT2 as Novel Aggressive Prostate Cancer Susceptibility Genes.
Crawford et al., Bethesda, United States. In Plos Genet, 30 Nov 2014
Although prostate cancer typically runs an indolent course, a subset of men develop aggressive, fatal forms of this disease.
The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.
Paul et al., Kansas City, United States. In Front Biosci, Dec 2013
The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of genomic integrity.
Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis.
Yin et al., Nanjing, China. In Int J Genomics, Dec 2013
Nuclear factor- κ B is associated with the pathogenesis of numerous malignancies, and the functional polymorphism -94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk.
rs833061 and rs699947 on Promoter Gene of Vascular Endothelial Growth Factor (VEGF) and Associated Lung Cancer Susceptibility and Survival: A Meta-Analysis.
Tian et al., Jinhua, China. In Med Sci Monit, Dec 2013
UNLABELLED: Background As 2 important SNPs located in the promoter region of VEGF gene, the roles of rs833061 (-460C>T) and rs699947 (-2578C>A) in lung cancer susceptibility and survival remain inconclusive and controversial.
Association of CYP2E1 and NAT2 Polymorphisms with Lung Cancer Susceptibility among Mongolian and Han Populations in the Inner Mongolian Region.
Liu et al., Hohhot, China. In Asian Pac J Cancer Prev, Dec 2013
PURPOSE: To explore associations of CYP2E1 and NAT2 polymorphisms with lung cancer susceptibility among Mongolian and Han populations in the Inner Mongolian region.
Association of GWAS-Identified Lung Cancer Susceptibility Loci with Survival Length in Patients with Small-Cell Lung Cancer Treated with Platinum-Based Chemotherapy.
Lin et al., Beijing, China. In Plos One, Dec 2013
This study explored the association between lung cancer susceptibility loci tagged by single-nucleotide polymorphisms (SNPs) identified in the genome-wide association studies and length of survival in small-cell lung cancer (SCLC).
Exploration of the correlations between interferon-γ in patient serum and HEPACAM in bladder transitional cell carcinoma, and the interferon-γ mechanism inhibiting BIU-87 proliferation.
Zhang et al., Anqing, China. In J Urol, 2012
Results suggest an important connection between HEPACAM and interferon-gamma, which may inhibit BIU-87 proliferation through HEPACAM re-expression and p21(WAF1) up-regulation to arrest cells at the G(0)/G(1) phase
HepaCAM induces G1 phase arrest and promotes c-Myc degradation in human renal cell carcinoma.
Shen et al., Chongqing, China. In J Cell Biochem, 2011
Research implies that the decrease in c-Myc protein expression, resulting from ectopic expression of hepaCAM, may contribute to the inhibition of proliferation in these cells.
Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts.
Estévez et al., Barcelona, Spain. In Hum Mol Genet, 2011
study presents more detailed characterization of the effect of mutations found in MLC1 and GLIALCAM megalencephalic leukoencephalopathy with subcortical cysts
Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism.
van der Knaap et al., Barcelona, Spain. In Am J Hum Genet, 2011
Dominant HEPACAM mutations can cause either macrocephaly and mental retardation with or without autism or benign familial macrocephaly.
Cancer evolution and individual susceptibility.
Mao et al., Salamanca, Spain. In Integr Biol (camb), 2011
Cancer susceptibility is due to interactions between inherited genetic factors and exposure to environmental carcinogens.
Subtle variations in Pten dose determine cancer susceptibility.
Pandolfi et al., Boston, United States. In Nat Genet, 2010
Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG).
Exon 2 methylation inhibits hepaCAM expression in transitional cell carcinoma of the bladder.
Shen et al., Chongqing, China. In Urol Int, 2009
Downregulation of hepaCAM expression plays an important role in the tumorigenesis and development of bladder cancer
The roles of cell adhesion molecules in tumor suppression and cell migration: a new paradox.
Shen et al., Singapore, Singapore. In Cell Adh Migr, 2009
Paradoxically, in 2005, we identified an immunoglobulin superfamily cell adhesion molecule hepaCAM that is able to suppress cancer cell growth and yet induce migration.
Cancer susceptibility: epigenetic manifestation of environmental exposures.
Jirtle et al., Durham, United States. In Cancer J, 2007
Cancer is a disease that results from both genetic and epigenetic changes.
Cancer susceptibility in the mouse: genetics, biology and implications for human cancer.
Demant, Buffalo, United States. In Nat Rev Genet, 2003
Growing evidence that a large proportion of apparently non-hereditary sporadic cancers occur in genetically predisposed individuals has emphasized the need to identify the underlying susceptibility genes.
American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility.
American Society of Clinical Oncology, In J Clin Oncol, 2003
The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice, research needs, educational opportunities, requirement for informed consent, indications for genetic testing, regulation of laboratories, and protection from discrimination, as well as access to and reimbursement for cancer genetics services.
Cancer susceptibility and the functions of BRCA1 and BRCA2.
Venkitaraman, Cambridge, United Kingdom. In Cell, 2002
Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
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