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Hepatic and glial cell adhesion molecule

Cancer susceptibility, hepaCAM
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, AGE, Iris, HAD, POLYMERASE
Papers on Cancer susceptibility
Breast Cancer Susceptibility Genes Pile Up.
New
In Cancer Discov, 07 May 2015
UNASSIGNED: A large genome-wide association analysis has revealed 15 more SNPs associated with breast cancer, which could provide additional genetic markers for risk analysis.
Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci.
New
Easton et al., Cambridge, United States. In Cancer Epidemiol Biomarkers Prev, 02 May 2015
BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer (PrCa) risk which explain a substantial proportion of familial relative risk.
Genetic Association Between PER3 Genetic Polymorphisms and Cancer Susceptibility: A Meta-Analysis.
New
Liang et al., Chongqing, China. In Medicine (baltimore), 30 Apr 2015
The mixed findings, however, make the role of the 2 variants in cancer susceptibility elusive.
A Pilot Genome-wide Association Study of Breast Cancer Susceptibility Loci in Indonesia.
New
Sari et al., Jakarta, Indonesia. In Asian Pac J Cancer Prev, Dec 2014
Genome-wide association studies (GWASs) of the entire genome provide a systematic approach for revealing novel genetic susceptibility loci for breast cancer.
Interactions between Environmental Factors and Melatonin Receptor Type 1A Polymorphism in Relation to Oral Cancer Susceptibility and Clinicopathologic Development.
New
Chien et al., T'ai-chung-shih, Taiwan. In Plos One, Dec 2014
CONCLUSION: These results support gene-environment interactions of MTNR1A polymorphisms with smoking and betel quid-chewing habits possibly altering oral-cancer susceptibility and metastasis.
The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.
Review
Paul et al., Kansas City, United States. In Front Biosci, 2013
The Breast Cancer Susceptibility Genes, BRCA1 and BRCA2, are the dynamic regulators of genomic integrity.
Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis.
Review
Yin et al., Nanjing, China. In Int J Genomics, 2013
Nuclear factor- κ B is associated with the pathogenesis of numerous malignancies, and the functional polymorphism -94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk.
Exploration of the correlations between interferon-γ in patient serum and HEPACAM in bladder transitional cell carcinoma, and the interferon-γ mechanism inhibiting BIU-87 proliferation.
GeneRIF
Zhang et al., Anqing, China. In J Urol, 2012
Results suggest an important connection between HEPACAM and interferon-gamma, which may inhibit BIU-87 proliferation through HEPACAM re-expression and p21(WAF1) up-regulation to arrest cells at the G(0)/G(1) phase
HepaCAM induces G1 phase arrest and promotes c-Myc degradation in human renal cell carcinoma.
GeneRIF
Shen et al., Chongqing, China. In J Cell Biochem, 2011
Research implies that the decrease in c-Myc protein expression, resulting from ectopic expression of hepaCAM, may contribute to the inhibition of proliferation in these cells.
Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts.
GeneRIF
Estévez et al., Barcelona, Spain. In Hum Mol Genet, 2011
study presents more detailed characterization of the effect of mutations found in MLC1 and GLIALCAM megalencephalic leukoencephalopathy with subcortical cysts
Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism.
GeneRIF
van der Knaap et al., Barcelona, Spain. In Am J Hum Genet, 2011
Dominant HEPACAM mutations can cause either macrocephaly and mental retardation with or without autism or benign familial macrocephaly.
Cancer evolution and individual susceptibility.
Review
Mao et al., Salamanca, Spain. In Integr Biol (camb), 2011
Cancer susceptibility is due to interactions between inherited genetic factors and exposure to environmental carcinogens.
Subtle variations in Pten dose determine cancer susceptibility.
Impact
Pandolfi et al., Boston, United States. In Nat Genet, 2010
Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG).
Exon 2 methylation inhibits hepaCAM expression in transitional cell carcinoma of the bladder.
GeneRIF
Shen et al., Chongqing, China. In Urol Int, 2009
Downregulation of hepaCAM expression plays an important role in the tumorigenesis and development of bladder cancer
The roles of cell adhesion molecules in tumor suppression and cell migration: a new paradox.
Review
Shen et al., Singapore, Singapore. In Cell Adh Migr, 2009
Paradoxically, in 2005, we identified an immunoglobulin superfamily cell adhesion molecule hepaCAM that is able to suppress cancer cell growth and yet induce migration.
Cancer susceptibility: epigenetic manifestation of environmental exposures.
Review
Jirtle et al., Durham, United States. In Cancer J, 2007
Cancer is a disease that results from both genetic and epigenetic changes.
Cancer susceptibility in the mouse: genetics, biology and implications for human cancer.
Review
Impact
Demant, Buffalo, United States. In Nat Rev Genet, 2003
Growing evidence that a large proportion of apparently non-hereditary sporadic cancers occur in genetically predisposed individuals has emphasized the need to identify the underlying susceptibility genes.
American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility.
Impact
American Society of Clinical Oncology, In J Clin Oncol, 2003
The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice, research needs, educational opportunities, requirement for informed consent, indications for genetic testing, regulation of laboratories, and protection from discrimination, as well as access to and reimbursement for cancer genetics services.
Cancer susceptibility and the functions of BRCA1 and BRCA2.
Review
Impact
Venkitaraman, Cambridge, United Kingdom. In Cell, 2002
Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation.
Impact
Nussenzweig et al., Bethesda, United States. In Nature, 2000
Cancer susceptibility genes have been classified into two groups: gatekeepers and caretakers.
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