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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 29 Mar 2014.

Hepatic and glial cell adhesion molecule

Cancer susceptibility, hepaCAM
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, AGE, Iris, HAD, POLYMERASE
Papers on Cancer susceptibility
Mutations in PIK3CD Can Cause Hyper IgM Syndrome (HIGM) Associated with Increased Cancer Susceptibility.
New
Rosenzweig et al., Bethesda, United States. In J Clin Immunol, 30 Apr 2014
Autosomal dominant gain of function mutations in the gene encoding PI3K p110δ were recently associated with a novel combined immune deficiency characterized by recurrent sinopulmonary infections, CD4 lymphopenia, reduced class-switched memory B cells, lymphadenopathy, CMV and/or EBV viremia and EBV-related lymphoma.
Renal tumor-derived exosomes inhibit hepaCAM expression of renal carcinoma cells in a p-AKT-dependent manner.
New
Wu et al., In Neoplasma, 20 Apr 2014
UNLABELLED: HepaCAM mediates cancer cell proliferation, migration and differentiation.
Promoter Methylation of the RASSF1A Gene may Contribute to Colorectal Cancer Susceptibility: A Meta-Analysis of Cohort Studies.
New
Zhang et al., Shenyang, China. In Ann Hum Genet, 13 Apr 2014
UNLABELLED: This meta-analysis of published cohort studies was conducted to evaluate whether promoter methylation of the RASSF1A gene contributes to colorectal cancer (CRC) susceptibility.
Correction: Association between PARP-1 V762A Polymorphism and Breast Cancer Susceptibility in Saudi Population.
New
PLOS ONE Staff, In Plos One, Dec 2013
[This corrects the article DOI: 10.1371/journal.pone.0085541.].
The Association between RAD23B Ala249Val Polymorphism and Cancer Susceptibility: Evidence from a Meta-Analysis.
New
Chen et al., Shaoxing, China. In Plos One, Dec 2013
BACKGROUND: A number of studies have investigated associations of genetic variation in RAD23B Ala249Val (rs1805329 C>T) with cancer susceptibility; however, the findings are inconsistent.
Impact of XRCC2 Arg188His Polymorphism on Cancer Susceptibility: A Meta-Analysis.
New
Wang et al., Chengdu, China. In Plos One, Dec 2013
BACKGROUND: Association between the single nucleotide polymorphism rs3218536 (known as Arg188His) located in the X-ray repair cross complementing group 2 (XRCC2) gene and cancer susceptibility has been widely investigated.
Exploration of the correlations between interferon-γ in patient serum and HEPACAM in bladder transitional cell carcinoma, and the interferon-γ mechanism inhibiting BIU-87 proliferation.
GeneRIF
Zhang et al., Anqing, China. In J Urol, 2012
Results suggest an important connection between HEPACAM and interferon-gamma, which may inhibit BIU-87 proliferation through HEPACAM re-expression and p21(WAF1) up-regulation to arrest cells at the G(0)/G(1) phase
HepaCAM induces G1 phase arrest and promotes c-Myc degradation in human renal cell carcinoma.
GeneRIF
Shen et al., Chongqing, China. In J Cell Biochem, 2011
Research implies that the decrease in c-Myc protein expression, resulting from ectopic expression of hepaCAM, may contribute to the inhibition of proliferation in these cells.
Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts.
GeneRIF
Estévez et al., Barcelona, Spain. In Hum Mol Genet, 2011
study presents more detailed characterization of the effect of mutations found in MLC1 and GLIALCAM megalencephalic leukoencephalopathy with subcortical cysts
Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism.
GeneRIF
van der Knaap et al., Barcelona, Spain. In Am J Hum Genet, 2011
Dominant HEPACAM mutations can cause either macrocephaly and mental retardation with or without autism or benign familial macrocephaly.
Cancer evolution and individual susceptibility.
Review
Mao et al., Salamanca, Spain. In Integr Biol (camb), 2011
Cancer susceptibility is due to interactions between inherited genetic factors and exposure to environmental carcinogens.
Subtle variations in Pten dose determine cancer susceptibility.
Impact
Pandolfi et al., Boston, United States. In Nat Genet, 2010
Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG).
Exon 2 methylation inhibits hepaCAM expression in transitional cell carcinoma of the bladder.
GeneRIF
Shen et al., Chongqing, China. In Urol Int, 2009
Downregulation of hepaCAM expression plays an important role in the tumorigenesis and development of bladder cancer
The roles of cell adhesion molecules in tumor suppression and cell migration: a new paradox.
Review
Shen et al., Singapore, Singapore. In Cell Adh Migr, 2009
Paradoxically, in 2005, we identified an immunoglobulin superfamily cell adhesion molecule hepaCAM that is able to suppress cancer cell growth and yet induce migration.
Cancer susceptibility: epigenetic manifestation of environmental exposures.
Review
Jirtle et al., Durham, United States. In Cancer J, 2007
Cancer is a disease that results from both genetic and epigenetic changes.
Genetic risk profiles for cancer susceptibility and therapy response.
Review
Schmezer et al., Heidelberg, Germany. In Recent Results Cancer Res, 2006
Inherited and acquired deficiencies in host defense mechanisms against DNA damage (metabolic and DNA repair enzymes) can modify cancer susceptibility as well as therapy response.
Cancer susceptibility in the mouse: genetics, biology and implications for human cancer.
Review
Impact
Demant, Buffalo, United States. In Nat Rev Genet, 2003
Growing evidence that a large proportion of apparently non-hereditary sporadic cancers occur in genetically predisposed individuals has emphasized the need to identify the underlying susceptibility genes.
American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility.
Impact
American Society of Clinical Oncology, In J Clin Oncol, 2003
The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice, research needs, educational opportunities, requirement for informed consent, indications for genetic testing, regulation of laboratories, and protection from discrimination, as well as access to and reimbursement for cancer genetics services.
Cancer susceptibility and the functions of BRCA1 and BRCA2.
Review
Impact
Venkitaraman, Cambridge, United Kingdom. In Cell, 2002
Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation.
Impact
Nussenzweig et al., Bethesda, United States. In Nature, 2000
Cancer susceptibility genes have been classified into two groups: gatekeepers and caretakers.
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