GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 14 Mar 2013.
Hepatic and glial cell adhesion molecule
Cancer susceptibility, hepaCAM
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011] (from
NCBI)
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Papers on
Cancer susceptibility
Multiplex Genetic Testing for Cancer Susceptibility: Out on the High Wire Without a Net?
New
Impact
Philadelphia, United States. In J Clin Oncol, 04 Apr 2013
Association of IL-12, IL-18 Variants and Serum IL 18 with Bladder Cancer Susceptibility in North Indian population.
New
In Gene, 08 Mar 2013
IL-12 and IL-18 are immunomodulatory cytokines that play important roles in host immune response against cancers.
Functional Variants in TNFAIP8 Associated with Cervical Cancer Susceptibility and Clinical Outcomes.
New
Shanghai, China. In Carcinogenesis, 08 Feb 2013
Single nucleotide polymorphisms (SNPs) at microRNA binding sites may change mRNA target gene function, thus leading to cancer susceptibility and tumor progression.
The Impact of 3'UTR Variants on Differential Expression of Candidate Cancer Susceptibility Genes.
New
Columbus, United States. In Plos One, Dec 2012
Variants in regulatory regions are predicted to play an important role in disease susceptibility of common diseases.
The Interleukin-10 Promoter Polymorphism rs1800872 (-592C>A), Contributes to Cancer Susceptibility: Meta-Analysis of 16 785 Cases and 19 713 Controls.
New
Nehe, China. In Plos One, Dec 2012
These results suggested that the -592C>A polymorphism might contribute to the cancer susceptibility, especially in smoking-related cancer, Asians and hospital-based studies.
PAI-1 4G/5G Polymorphism Contributes to Cancer Susceptibility: Evidence from Meta-Analysis.
New
Nanjing, China. In Plos One, Dec 2012
BACKGROUND: The plasminogen activator inhibitor-1 (PAI-1) is expressed in many cancer cell types and allows the modulation of cancer growth, invasion and angiogenesis.
The CHEK2 I157T variant and breast cancer susceptibility: a systematic review and meta-analysis.
Review
Shanghai, China. In Asian Pac J Cancer Prev, 2011
BACKGROUND: The cell cycle checkpoint kinase 2 (CHEK2) gene I157T variant may be associated with an increased risk of breast cancer, but it is unclear whether the evidence is sufficient to recommend testing for the mutation in clinical practice.
Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts.
GeneRIF
Barcelona, Spain. In Hum Mol Genet, 2011
study presents more detailed characterization of the effect of mutations found in MLC1 and GLIALCAM megalencephalic leukoencephalopathy with subcortical cysts
Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism.
GeneRIF
Barcelona, Spain. In Am J Hum Genet, 2011
Dominant HEPACAM mutations can cause either macrocephaly and mental retardation with or without autism or benign familial macrocephaly.
Cancer evolution and individual susceptibility.
Review
Salamanca, Spain. In Integr Biol (camb), 2011
Cancer susceptibility is due to interactions between inherited genetic factors and exposure to environmental carcinogens.
Expression and clinical significance of hepaCAM and VEGF in urothelial carcinoma.
GeneRIF
Chongqing, China. In World J Urol, 2010
There is a close relationship between hepaCAM and VEGF in urothelial carcinoma
The immunoglobulin-like cell adhesion molecule hepaCAM is cleaved in the human breast carcinoma MCF7 cells.
GeneRIF
Singapore, Singapore. In Int J Oncol, 2010
The truncation mutant of hepaCAM failed to promote cell-ECM adhesion and migration, and lost the inhibitory effects on cell growth, suggesting a regulatory role of the cleavage in hepaCAM functions.
Subtle variations in Pten dose determine cancer susceptibility.
Impact
Boston, United States. In Nat Genet, 2010
Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG).
Exon 2 methylation inhibits hepaCAM expression in transitional cell carcinoma of the bladder.
GeneRIF
Chongqing, China. In Urol Int, 2009
Downregulation of hepaCAM expression plays an important role in the tumorigenesis and development of bladder cancer
The roles of cell adhesion molecules in tumor suppression and cell migration: a new paradox.
Review
Singapore, Singapore. In Cell Adh Migr, 2009
Paradoxically, in 2005, we identified an immunoglobulin superfamily cell adhesion molecule hepaCAM that is able to suppress cancer cell growth and yet induce migration.
Cancer susceptibility: epigenetic manifestation of environmental exposures.
Review
Durham, United States. In Cancer J, 2007
Cancer is a disease that results from both genetic and epigenetic changes.
Genetic risk profiles for cancer susceptibility and therapy response.
Review
Heidelberg, Germany. In Recent Results Cancer Res, 2006
Inherited and acquired deficiencies in host defense mechanisms against DNA damage (metabolic and DNA repair enzymes) can modify cancer susceptibility as well as therapy response.
Cancer susceptibility in the mouse: genetics, biology and implications for human cancer.
Review
Impact
Buffalo, United States. In Nat Rev Genet, 2003
Growing evidence that a large proportion of apparently non-hereditary sporadic cancers occur in genetically predisposed individuals has emphasized the need to identify the underlying susceptibility genes.
American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility.
Impact
In J Clin Oncol, 2003
The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice, research needs, educational opportunities, requirement for informed consent, indications for genetic testing, regulation of laboratories, and protection from discrimination, as well as access to and reimbursement for cancer genetics services.
Cancer susceptibility and the functions of BRCA1 and BRCA2.
Review
Impact
Cambridge, United Kingdom. In Cell, 2002
Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
