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Hepatic and glial cell adhesion molecule

Cancer susceptibility, hepaCAM
The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011] (from NCBI)
Top mentioned proteins: CAN, AGE, HAD, Iris, POLYMERASE
Papers on Cancer susceptibility
ATG16L1 T300A Polymorphism is Correlated with Gastric Cancer Susceptibility.
Ioana et al., Craiova, Romania. In Pathol Oncol Res, 07 Dec 2015
UNASSIGNED: Gastric cancer is a major leading cause of cancer-related death in both sexes in Europe.
American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility.
Lindor et al., Philadelphia, United States. In J Clin Oncol, 01 Dec 2015
In particular, there was an interest in addressing the opportunities and challenges arising from the application of massively parallel sequencing-also known as next-generation sequencing-to cancer susceptibility testing.
The Role of Methylation in Breast Cancer Susceptibility and Treatment.
Durocher et al., Québec, Canada. In Anticancer Res, Sep 2015
DNA methylation is a critical mechanism of epigenetic modification involved in gene expression programming, that can promote the development of several cancers, including breast cancer.
Genetic Association Between NFKBIA -881A>G Polymorphism and Cancer Susceptibility.
Liang et al., Chongqing, China. In Medicine (baltimore), Aug 2015
Several epidemiological studies have focused on the role of nuclear factor-kappa-B inhibitor-alpha (NFKBIA) -881 A>G polymorphism in cancer susceptibility.
Association between the CYP1A2 rs762551 Polymorphism and Bladder Cancer Susceptibility: a Meta-Analysis Based on Case-Control Studies.
Liu et al., Shaoxing, China. In Asian Pac J Cancer Prev, Dec 2014
Overall, a significant association was found between the CYP1A2 rs762551 polymorphism and bladder cancer susceptibility for CC vs AA (OR=0.82,
Influence of the CYP1A1 T3801C Polymorphism on Tobacco and Alcohol-Associated Head and Neck Cancer Susceptibility in Northeast India.
Ghosh et al., Silchar, India. In Asian Pac J Cancer Prev, Dec 2014
BACKGROUND: Tobacco and alcohol contain or may generate carcinogenic compounds related to cancers.
Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility.
Liu et al., Yangzhou, China. In Gastroenterol Res Pract, Dec 2014
Possible Gender-Related Modulation by the ROCK1 Gene in Colorectal Cancer Susceptibility.
Solmi et al., Bologna, Italy. In Pathobiology, Dec 2014
AIM: In view of accumulating evidence supporting a pivotal role of the Rho/ROCK pathway in cancer, we investigated Rho-kinase polymorphisms as potential susceptibility factors in colorectal cancer (CRC) in a representative sample of the Italian population.
AXIN2 Polymorphisms, the β-Catenin Destruction Complex Expression Profile and Breast Cancer Susceptibility.
Takahashi et al., Ribeirão Preto, Brazil. In Asian Pac J Cancer Prev, Dec 2014
BACKGROUND: The Wnt/β-catenin signaling pathway is an important regulator of cellular functions such as proliferation, survival and cell adhesion.
Molecular and genetic epidemiology of cancer in low- and medium-income countries.
Malhotra, New York City, United States. In Ann Glob Health, Sep 2014
BACKGROUND: Genetic and molecular factors can play an important role in an individual's cancer susceptibility and response to carcinogen exposure.
Association between NFKB1 -94ins/del ATTG Promoter Polymorphism and Cancer Susceptibility: An Updated Meta-Analysis.
Yin et al., Nanjing, China. In Int J Genomics, 2013
Nuclear factor- κ B is associated with the pathogenesis of numerous malignancies, and the functional polymorphism -94ins/del ATTG (rs28362491) in the human NFKB1 gene is associated with cancer risk.
Exploration of the correlations between interferon-γ in patient serum and HEPACAM in bladder transitional cell carcinoma, and the interferon-γ mechanism inhibiting BIU-87 proliferation.
Zhang et al., Anqing, China. In J Urol, 2012
Results suggest an important connection between HEPACAM and interferon-gamma, which may inhibit BIU-87 proliferation through HEPACAM re-expression and p21(WAF1) up-regulation to arrest cells at the G(0)/G(1) phase
HepaCAM induces G1 phase arrest and promotes c-Myc degradation in human renal cell carcinoma.
Shen et al., Chongqing, China. In J Cell Biochem, 2011
Research implies that the decrease in c-Myc protein expression, resulting from ectopic expression of hepaCAM, may contribute to the inhibition of proliferation in these cells.
Molecular mechanisms of MLC1 and GLIALCAM mutations in megalencephalic leukoencephalopathy with subcortical cysts.
Estévez et al., Barcelona, Spain. In Hum Mol Genet, 2011
study presents more detailed characterization of the effect of mutations found in MLC1 and GLIALCAM megalencephalic leukoencephalopathy with subcortical cysts
Mutant GlialCAM causes megalencephalic leukoencephalopathy with subcortical cysts, benign familial macrocephaly, and macrocephaly with retardation and autism.
van der Knaap et al., Barcelona, Spain. In Am J Hum Genet, 2011
Dominant HEPACAM mutations can cause either macrocephaly and mental retardation with or without autism or benign familial macrocephaly.
Subtle variations in Pten dose determine cancer susceptibility.
Pandolfi et al., Boston, United States. In Nat Genet, 2010
Cancer susceptibility has been attributed to at least one heterozygous genetic alteration in a tumor suppressor gene (TSG).
Exon 2 methylation inhibits hepaCAM expression in transitional cell carcinoma of the bladder.
Shen et al., Chongqing, China. In Urol Int, 2009
Downregulation of hepaCAM expression plays an important role in the tumorigenesis and development of bladder cancer
Cancer susceptibility in the mouse: genetics, biology and implications for human cancer.
Demant, Buffalo, United States. In Nat Rev Genet, 2003
Growing evidence that a large proportion of apparently non-hereditary sporadic cancers occur in genetically predisposed individuals has emphasized the need to identify the underlying susceptibility genes.
American Society of Clinical Oncology policy statement update: genetic testing for cancer susceptibility.
American Society of Clinical Oncology, In J Clin Oncol, 2003
The 1996 ASCO Statement on Genetic Testing for Cancer Susceptibility set forth specific recommendations relating to clinical practice, research needs, educational opportunities, requirement for informed consent, indications for genetic testing, regulation of laboratories, and protection from discrimination, as well as access to and reimbursement for cancer genetics services.
Cancer susceptibility and the functions of BRCA1 and BRCA2.
Venkitaraman, Cambridge, United Kingdom. In Cell, 2002
Inherited mutations in BRCA1 or BRCA2 predispose to breast, ovarian, and other cancers.
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